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KSME International Journal

, Volume 14, Issue 8, pp 861–866 | Cite as

Streamlined shape of endothelial cells

  • Chanil Chung
  • Jun Keun Chang
  • Byoung Goo Min
  • Dong Chul Han
Thermal Engineering · Fluid Engineering · Energy and Power Engineering
  • 94 Downloads

Abstract

Flow induced shape change is important for spatial interpretation of vascular response and for understanding of mechanotransduction in a single cell. We investigated the possible shapes of endothelial cell (EC) in a mathematical model and compared these with experimental results. The linearized analytic solution from the sinusoidal wavy wall and Stokes flow was applied with the constraint of EC volume. The three dimensional structure of the human umbilical vein endothelial cell was visualized in static culture or after various durations of shear stress (20 dyne/cm2 for 5, 10, 20, 40, 60, 120min). The shape ratio (width: length: height) of model agreed with that of the experimental result, which represented the drag force minimizing shape of stream-lining. EC would be streamlined in order to accommodate to the shear flow environmented by active reconstruction of cytoskeletons and membranes through a drag force the sensing mechanism.

Key Words

Endothelial Cell Drag Force Stream Lining Shape Cytoskeleton 

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Copyright information

© The Korean Society of Mechanical Engineers (KSME) 2000

Authors and Affiliations

  • Chanil Chung
    • 1
  • Jun Keun Chang
    • 4
  • Byoung Goo Min
    • 2
  • Dong Chul Han
    • 3
  1. 1.Institute of Medical and Biological Engineering in Medical Research CenterSeoul National UniversityKorea
  2. 2.Department of Biomedical EngineeringSeoul Natiuonal UniversityKorea
  3. 3.School of Mechanical and Aerospace EngineeringSeoul National UniversityKorea
  4. 4.School of Electrical Engineering and Computer ScienceSeoul National UniversitySeoulKorea

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