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Chinese Science Bulletin

, Volume 50, Issue 12, pp 1169–1173 | Cite as

Matrix metalloproteinases (MMPs) and trophoblast invasion

  • Jing Li
  • Tianfu Zhao
  • Enkui Duan
Review

Abstract

MMPs and their natural tissue inhibitors TIMPs are crucial in coordinated breakdown and remodeling of the extracellular matrix (ECM) in physiological and pathological situations. Placentation is a key event of pregnancy in which MMPs/TIMPs system plays important roles in regulating the extravillus cytotrophoblast (EVTs) invasion. This paper focuses on expression patterns and regulatory mechanisms of MMPs/TIMPs family members during the process of placentation. Their implications in curing pregnancy-related diseases are also discussed.

Keywords

MMPs TIMPs placenta trophoblast invasion extracellular matrix (ECM) 

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Copyright information

© Science in China Press 2005

Authors and Affiliations

  1. 1.State Key Laboratory of Reproductive Biology, Institute of ZoologyChinese Academy of SciencesBeijingChina
  2. 2.Graduate School of the Chinese Academy of SciencesBeijingChina
  3. 3.Department of BiologyBaoding Teacher’s CollegeBaodingChina

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