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Chinese Science Bulletin

, Volume 50, Issue 22, pp 2657–2661 | Cite as

Synchrotron refractive-index microradiography of human liver cancer tissue

  • Yongpeng Tong
  • Guilin Zhang
  • Yan Li
  • Yeukuang Hwu
  • Wenli Tsai
  • Jung Ho Je
  • G. Margaritondo
  • Dong Yuan
Articles
  • 38 Downloads

Abstract

Three human liver tissue samples (∼5 mm × 40 mm × 20 mm) were excised from a cancer patient’s liver during surgery. The microradiology analysis was performed with a non-standard approach on a synchrotron. High-resolution refractive-index edge-enhanced microradiographs that cover a larger volume of the liver tissue sample were obtained. The cancer tissue and normal tissue could be clearly identified and distinguished based on their different textures. Furthermore, new blood vessel hyperplasia was found near the cancer area. Blood vessels with a diameter smaller than 20 μm could be identified. These findings were fully consistent with the histopathological examination of the same area. Microradiographs of the newly formed blood vessels at different angles were also obtained. This result shows that it is possible to further develop this approach into a technique of microradiographic imaging for clinic diagnosis of liver cancer at the early stage.

Keywords

synchrotron microradiology liver cancer histopathology 

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References

  1. 1.
    Rontgen, W. C., On a new kind of ray, a preliminary communication. Wurzbugg Physico-Medical Society on December 28, 1895 (translated by Stanton, A.), Nature, 1896, 53, 274.Google Scholar
  2. 2.
    Liang, E. Y., Chan, M., Hsiang, J. H. K. et al., Detection and assessment of intracranial aneurysms: Value of CT angiography with shaded-surface display, AJR, 1996, 165: 1497.Google Scholar
  3. 3.
    Zerhouni, E. A., Stitik, F. P., Siegelman, S. S. et al., CT of the pulmonary nodule: A cooperative study, Radiology, 1986, 160: 319–327.Google Scholar
  4. 4.
    Furman-Haran, E., Margalit, R., Grobgeld, D., Degani, H., High resolution MRI of MCF7 human breast tumors: Complemented use of iron oxide microspheres and Gd-DTPA, JMRI, 1998, 8: 634–641.CrossRefGoogle Scholar
  5. 5.
    Fitzgerald, R., Phase-sensitive X-ray imaging, Physics Today, 2000, 53: 23.CrossRefGoogle Scholar
  6. 6.
    Hwu, Y., Tsai, W. L., Je, H. J. et al., Coherence based contrast enhancement in X-ray radiography with a photoelectron microscope, Appl. Phys. Lett., 1999, 75: 2377–2379.CrossRefGoogle Scholar
  7. 7.
    Hwu, Y., Tsai, W. L., Je, H. J. et al., Synchrotron microangiograph with no contrast agent, Phys. Med. Biol., 2004, 49: 501–508.CrossRefGoogle Scholar
  8. 8.
    Hwu, Y., Hsieh, H. H., Lu, M. J. et al., Coherence-enhanced synchrotron radiology: Refraction versus diffraction mechanisms, J. Appl. Phys., 1999, 86: 4613–4618.CrossRefGoogle Scholar

Copyright information

© Science in China Press 2005

Authors and Affiliations

  • Yongpeng Tong
    • 1
  • Guilin Zhang
    • 1
  • Yan Li
    • 1
  • Yeukuang Hwu
    • 2
  • Wenli Tsai
    • 2
  • Jung Ho Je
    • 3
  • G. Margaritondo
    • 4
  • Dong Yuan
    • 5
  1. 1.Shanghai Institute of Applied PhysicsChinese Academy of SciencesShanghaiChina
  2. 2.Institute of PhysicsAcademia SinicaNankang, TaipeiChina
  3. 3.Department of Material Science and EngineeringPohang Universty of Science and TechnologyPohangKorea
  4. 4.IPA-Ecole Polytechnique Federale de Lausanne (EPFL)LausanneSwitzerland
  5. 5.Shanghai CDCShanghaiChina

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