Chinese Science Bulletin

, Volume 45, Issue 22, pp 2017–2028 | Cite as

Research progresses of artificial nucleic acid cleavage agents

  • Rong Wan
  • Gang Zhao
  • Jing Chen
  • Yufen Zhao


Artificial nucleic acid cleavage agents have attracted close attention because they play important roles in biochemistry and molecular biology. According to the cleavage mechanism of nucleic acid, they are divided into three types, namely free radical, phosphodiester bond hydrolysis and elimination cleavage agents. In this review, a series of cleavage agents, including the site- and sequence-specific ones, are illustrated, and some suggestions for the future researches in this field are also put forward.


nucleic acid cleavage agents site- and sequence-specific cleavage agents free radical phosphodiester bond hydrolysis elimination 


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© Science in China Press 2000

Authors and Affiliations

  1. 1.State Key Laboratory of Bioorganic Phosphorus Chemistry of Education Ministry of China, Department of Chemistry, School of Life Science and EngineeringTsinghua UniversityBeijingChina

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