Proceedings: Animal Sciences

, Volume 97, Issue 6, pp 491–497 | Cite as

Haemodynamics of hamsters duringAncylostoma ceylanicum infection

  • J K Srivastava
  • Suman Gupta
  • J C Katiyar


Alterations in haematological and liver glycogen values during the course ofAncylostoma ceylanicum (100L3, p.o.) infection in hamsters were investigated. In early phase of infection, there were marginal changes in haematological parameters, albuminglobulin ratio and liver glycogen, which transformed into severe alterations on patency (day 18, post infection). Haemoglobin, packed cell volume, total erythrocyte counts and liver glycogen values had a decreasing trend and reticulocytes increased considerably to compensate the red blood cell loss. Albumin/globulin ratio which was in favour of albumin in the beginning, reversed on day 24 p.i. When the animals were deparasitized with mebendazole (5 mg/kgxl, p.o.), all the parameters started resuming normalcy and on day 12 of treatment of all the parameters except albumin/globulin ratio attained the preinfection level.


Ancylostoma ceylanicum hamster haemodynamics liver glycogen 


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  1. Anon 1978Manual of Veterinary investigation laboratory technique, Part 4. Haematology 2nd edition (London: Ministry of Agriculture, Fisheries and Food)Google Scholar
  2. Baker N F 1962 The nature and etiology of the leukocyte response of Webster mice infected withNematospiroides dubium;J. Parasitol. 48 438–441CrossRefPubMedGoogle Scholar
  3. Boyer M H, Spry C J F, Beeson P B and Sheldon W H 1971 Mechanism of eosinophilia IV. The pulmonary lesion resulting from intravenous injection ofTrichinella spiralis;Yale J. Biol. Med. 43 351–356PubMedGoogle Scholar
  4. Briero R O and Mull J D 1964 Electrophoresis of serum proteins with cellulose acetate;Am. J. Clin. Pathol. 42 547–551Google Scholar
  5. Carroll S M and Grove D I 1985Ancylostoma ceylanicum: immunization with soluble worm extract and responses to challenge infection of dogs;Exp. Parasitol. 60 263–267CrossRefPubMedGoogle Scholar
  6. Chatterjee K D 1967Phylum nemathelminthes—Ancylostoma duodenale parasitology (protozoology and helminthology) in relation to clinical medicine (Calcutta, India: Chatterjee Medical Publishers) VI editionGoogle Scholar
  7. Cheema K J and Scofield A M 1984 The influence of level of infection of ratsNippostrongylus brasiliensis on the haematology and phospholipaseactivity and mast cell numbers in the small intestine and colon;Int. J. Parasitol. 15 55–60CrossRefGoogle Scholar
  8. Good A, Kramar H G and Somagyi M 1933 The determination of glycogen;J. Bio. Chem. 100 485–491Google Scholar
  9. Gupta S and Katiyar J C 1985 Immunological response of hamster toAncylostoma ceylanicum infection;Helminthologia 22 181–184Google Scholar
  10. Gupta S, Srivastava J K and Katiyar J C 1987Ancylostoma ceylanicum: migratory behaviour in golden hamsters after oral and parenteral infection;Ann. Trop. Med. Parasitol. 81 412–442Google Scholar
  11. Hoagland K E and Schad G A 1978Necator americanus andAncylostoma duodenale: Life history parameters and epidimiological implication of two sympatric hookworms of humans;Exp. Parasitol. 44 36–49CrossRefPubMedGoogle Scholar
  12. Jane M P 1979Beckman, microzone electrophoresis manual (California: Beckman Instrument. Inc. Fullerton)Google Scholar
  13. Katiyar J C, Visen P K S, Gupta S, Sen A B, Dubey S K and Sharma S 1982 3,5-Dibroma-2′-chloro-4′-isothiocynato salicylanilide, a potent anthelmintic;Experientia 38 457–459CrossRefPubMedGoogle Scholar
  14. Katiyar J C, Visen P K S, Misra A, Gupta S and Bhaduri A P 1984 Methyl 5(6)-4-2-pyridyl piperazino carbamoyl benzimidazole-2-carbamate-a new broad spectrum anthelmintic;Acta Trop. 41 279–286PubMedGoogle Scholar
  15. Kaul G L, Talwalker P K, Sen H G and Grewal R S 1982 Changes in carbohydrate metabolism in golden hamsters infected withNecator americanus;Ann. Trop. Med. Parasitol. 76 475–482PubMedGoogle Scholar
  16. Misra A, Visen P K S and Katiyar J C 1981 Comparative efficacy of standard antihookworm drugs against various nematodes;J. Helminthol. 55 273–278CrossRefPubMedGoogle Scholar
  17. Montgomery R 1957 Determination of glycogen;Arch. Biochem. Biophys. 67 378–386CrossRefPubMedGoogle Scholar
  18. Maqbel R 1980 Histological changes following primary secondary and repeated infections of rats withStrongyloides ratti, with special reference to tissue eosinophils;Parasite Immunol. 2 11–27CrossRefGoogle Scholar
  19. Ogilvie B M, Hesketh P M and Rose M E 1978Nippostrongylus brasiliensis: peripheral blood leucocyte response of rats, with special reference to basophils;Exp. Parasitol. 46 20–30CrossRefPubMedGoogle Scholar
  20. Ogilvie B M, Askenase P W and Rose M E 1980 Basophils and eosinophils in three strains of rats and in athymic (nude) rats following infection with nematodesNippostrongylus brasiliensis orTrichinella spiralis;Immunology 39 385–389PubMedGoogle Scholar
  21. Przyjalkowski Z, Kontny E and Cabaj W 1980 Haematological changes evoked byTrichinella spiralis as an index of the course of trichinellosis in germ free and conventional mice;Bull. Acad. Pol. Sci. 28 87–93Google Scholar
  22. Ray D K, Bhopale K K and Srivastava V B 1972 Migration and growth ofAncylostoma ceylanicum (Looss 1911) in golden hamstersMesocricetus auratus;J. Helminthol. 46 357–362CrossRefPubMedGoogle Scholar
  23. Roach M 1970 Ancylostomiasis and anaemia;Biol. Sanit. Panam. 69 221–228Google Scholar
  24. Roth R L and Levy D A 1980Nippostrongylus brasiliensis: peripheral leukocyte responses and correlation of basophils with blood histamine concentration during infection in rats;Exp. Parasitol. 50 331–341CrossRefPubMedGoogle Scholar
  25. Ruitenberg E J, Elgersma A, Kruizinga W and Leenstra F 1977Trichinella spiralis infection in congenitally athymic (nude) mice. Parasitological, serological and haematological studies with observations on intestinal pathology;Immunology 33 581–587PubMedGoogle Scholar
  26. Srivastava J K, Gupta S and Katiyar J C 1986 Behavioural studies on the arrestedAncylostoma ceylanicum larvae in hamsters;Riv. Parasitol. III (XLVII) 447–454Google Scholar
  27. Symons L E A 1969 Pathology of gastrointestinal helminthiases;Int. Rev. Trop. Med. 3 49–100PubMedGoogle Scholar
  28. Visen P K S, Katiyar J C and Sen A B 1984 Studies on infectivity, longevity and fecundity ofAncylostoma ceylanicum in golden hamsters;J. Helminthol. 58 159–164CrossRefPubMedGoogle Scholar
  29. Wakelin D and Donachie A M 1983 Genetic control of eosinophilia. Mouse strain variation in response to antigens of parasitic origin;Clin. Exp. Immunol. 51 239–246PubMedGoogle Scholar

Copyright information

© Indian Academy of Sciences 1988

Authors and Affiliations

  • J K Srivastava
    • 1
  • Suman Gupta
    • 1
  • J C Katiyar
    • 1
  1. 1.Division of ParasitologyCentral Drug Research InstituteLucknowIndia

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