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Effect of emodin on biological behavior of fibroblasts in lupus nephritis

  • Liu Guan-xian 
  • Ye Ren-gao 
  • Tan Zhi-ming 
  • Zhong Wei-qiang 
  • Yang Yong-ming 
  • Zhang Guo-qiang 
  • Fang Jing-ai 
Experimental Work And Research
  • 27 Downloads

Abstract

Objective: To observe the effect of emodin on the biological behavior of human fibroblasts (FB) in culture of kidney in patients with lupus nephritis (LN).Methods: FB were isolated from kidney culture of LN patients, and the effect of emodin on3H-TdR incorporated rate of FB was observed. The apoptosis and c-myc gene expression were detected in the same way by flow cytometry.Results: Emodin could markedly inhibit the proliferation of human kidney FB, and inducing cell apoptosis through up-regulating c-myc gene expression in human renal FB.Conclusion: Emodin can inhibit proliferation and promote apoptosis of FB, which may be important in ameliorating interstitial fibrosis, and thus improve prognosis of LN.

Key words

emodin fibroblast proliferation apoptosis c-myc protein 

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Copyright information

© The Chinese Journal of Integrated Traditional and Western Medicine Press 2001

Authors and Affiliations

  • Liu Guan-xian 
    • 1
  • Ye Ren-gao 
    • 2
  • Tan Zhi-ming 
    • 1
  • Zhong Wei-qiang 
    • 1
  • Yang Yong-ming 
    • 1
  • Zhang Guo-qiang 
    • 2
  • Fang Jing-ai 
    • 3
  1. 1.Department of NephrologyHuizhou Central People’s HospitalHuizhou City
  2. 2.Institute of NephrologySun Yat-sen University of Medical SciencePeople’s Republic of China
  3. 3.The First Affiliated HospitalShanxi Medical UniversityPeople’s Republic of China

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