Intracellular introduction of cyclo-oxygenase antisense oligonucleotide enhances chemotherapy-induced apoptosis and prevents chemoresistance in breast cancer
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COX-2 expression is significantly associated with resistance to drug-induced apoptosis and this effect is reversed by COX-2 ASO. NS-398 did not enhance apoptotic susceptibility or reverse the COX-2-induced resistance to apoptosis. This has future therapeutic implications.