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Intracellular introduction of cyclo-oxygenase antisense oligonucleotide enhances chemotherapy-induced apoptosis and prevents chemoresistance in breast cancer

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Conclusion

COX-2 expression is significantly associated with resistance to drug-induced apoptosis and this effect is reversed by COX-2 ASO. NS-398 did not enhance apoptotic susceptibility or reverse the COX-2-induced resistance to apoptosis. This has future therapeutic implications.

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Authors and Affiliations

  1. Department of Surgery, Mater Mlsericordiae Hospital, Dublin, Ireland

    T. L. Barry, R. W. G. Watson, D. O’Hanlon, T. F. Gorey, J. M. Fltzpatrick & M. J. Kerin

  2. The Conway Institute for Blomolecular and Biomedical Research, University College Dublin, Ireland

    T. L. Barry, R. W. G. Watson, J. M. Fltzpatrick & M. J. Kerin

Authors
  1. T. L. Barry
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  2. R. W. G. Watson
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  3. D. O’Hanlon
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  4. T. F. Gorey
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  5. J. M. Fltzpatrick
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  6. M. J. Kerin
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Barry, T.L., Watson, R.W.G., O’Hanlon, D. et al. Intracellular introduction of cyclo-oxygenase antisense oligonucleotide enhances chemotherapy-induced apoptosis and prevents chemoresistance in breast cancer. Ir J Med Sci 171 (Suppl 2), 45 (2002). https://doi.org/10.1007/BF03170078

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  • DOI: https://doi.org/10.1007/BF03170078

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