Advertisement

Intracellular introduction of cyclo-oxygenase antisense oligonucleotide enhances chemotherapy-induced apoptosis and prevents chemoresistance in breast cancer

  • T. L. Barry
  • R. W. G. Watson
  • D. O’Hanlon
  • T. F. Gorey
  • J. M. Fltzpatrick
  • M. J. Kerin
Session 7 Plenary session
  • 19 Downloads

Conclusion

COX-2 expression is significantly associated with resistance to drug-induced apoptosis and this effect is reversed by COX-2 ASO. NS-398 did not enhance apoptotic susceptibility or reverse the COX-2-induced resistance to apoptosis. This has future therapeutic implications.

Copyright information

© Springer 2002

Authors and Affiliations

  • T. L. Barry
    • 1
    • 2
  • R. W. G. Watson
    • 1
    • 2
  • D. O’Hanlon
    • 1
  • T. F. Gorey
    • 1
  • J. M. Fltzpatrick
    • 1
    • 2
  • M. J. Kerin
    • 1
    • 2
  1. 1.Department of SurgeryMater Mlsericordiae HospitalDublinIreland
  2. 2.The Conway Institute for Blomolecular and Biomedical ResearchUniversity College DublinIreland

Personalised recommendations