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A comparison in the detection of micrometastases in regional lymph nodes in patients with Duke’s A or B rectal carcinoma using CAM 5.2 immunohistochemical staining versus conventional staining

  • A. J. Hayanga
  • F. Glynn
  • H. Thakore
  • P. O’Kelly
  • E. Kay
  • P. Gillen
Session 6 GI

Conclusion

Immunohistochemical staining methods successfully identified micrometastatic foci in lymph nodes missed by conventional methods and may be a predictor of survival and a determinant of prognosis in patients with Duke’s A or B rectal carcinoma.

Further Reading List

  1. 1.
    Broil B, Schauer V, Schimmelpenning H. Prognostic relevance of occult tumour cells in lymph nodes of col orectal carcinomas. An immunohistochemical study. Dis Colon Rectum 1997; 40: 1465–71.CrossRefGoogle Scholar
  2. 2.
    Davidson BR, Sams VR, Styles J, Deane C, Boulos PB. Detection of occult nodal metastases in patients with colorectal carcinoma. Cancer 65: 967–70.Google Scholar
  3. 3.
    Adell G, Boeryd B, Franlund B, Sjodahl R, Hakansson L Occurrence and prognostic importance of micrometastases in Duke’s B colorectal carcinoma; an immunohistochemical study. Eur J Surg 1996; 162: 637–42.PubMedGoogle Scholar
  4. 4.
    Isaka N, Nozue M, Doy M, Fukao K. Prognostic signifi cance of perirectal lymph node micrometastases in Duke’s B colorectal carci noma: an immunohisto chemical study by CAM 5.2. Clin Cancer Res 1999: 5 (8); 2065–8.PubMedGoogle Scholar

Copyright information

© Springer 2002

Authors and Affiliations

  • A. J. Hayanga
    • 1
    • 2
  • F. Glynn
    • 1
    • 2
  • H. Thakore
    • 1
    • 2
  • P. O’Kelly
    • 1
    • 2
  • E. Kay
    • 1
    • 2
  • P. Gillen
    • 1
    • 2
  1. 1.Department of PathologyBeaumont HospitalIreland
  2. 2.Department of SurgeryOur Lady of Lourdes Hospital, DroghedaCo LouthIreland

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