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Atheroma-associated chemokines induce a rapid and transient increase in alpha4-betal (VLA-4) affinity on human monocytes

  • S. T. Duffy
  • J. R. Chan
  • M. I. Cybulsky
Session 5 Sepsis/Immunology
  • 17 Downloads

References

  1. 1.
    Cybulsky MI, Gimbrone MA, Jr. Endothelial expres sion of a mononuclear leukocyte adhesion mole cule during atherogenesis. Science 1991; 251 (4995): 788–91.CrossRefPubMedGoogle Scholar
  2. 2.
    Sasayama S, Okada M, Matsumori A. Chemokines and cardiovascular dis eases. Cardiovasc Res 2000; 45 (2): 267–9.CrossRefPubMedGoogle Scholar
  3. 3.
    Alon R et al. The integrin VLA-4 supports tethering and rolling in flow on VCAM-1. J Cell Biol 1995; 128(6): 1243–53.CrossRefPubMedGoogle Scholar
  4. 4.
    Berlin C et al. Alpha4 inte grins mediate lymphocyte attachment and rolling under physiologic flow. Cell 1995; 80 (3): 413–22.CrossRefPubMedGoogle Scholar
  5. 5.
    Chan JR, Hyduk SJ, Cybul sky MI. Chemoattractants induce a rapid and tran sient upregulation of monocyte alpha4 integrin affinity for vascular cell adhesion molecule 1 which mediates arrest: an early step in the process of emigration. J Exp Med 2001; 193(10): 1149–58.CrossRefPubMedGoogle Scholar
  6. 6.
    Chigaev A et al. Real time analysis of the affinity regulation of alpha4-inte grin. The physiologically activated receptor is inter mediate in affinity between resting and Mn (2 +) or antibody activa tion. J Biol Chem 2001; 276 (52): 48670–8.CrossRefPubMedGoogle Scholar

Copyright information

© Springer 2002

Authors and Affiliations

  • S. T. Duffy
    • 1
    • 2
    • 3
  • J. R. Chan
    • 1
    • 2
  • M. I. Cybulsky
    • 1
    • 2
  1. 1.Vascular Research GroupToronto General Research InstituteCanada
  2. 2.The Department of Laboratory Medicine and PathobiologyUniversity of TorontoCanada
  3. 3.Postgraduate Travelling Fellow in Surgery (2001/02)Trinity CollegeDublinIreland

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