Modulation of c-raf and cdc2 kinase-suryivin expression: role of cyclo-oxygenase inhibitors in breast cancer apoptosis
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These findings suggest aspirin and meloxicam modulate breast cancer cells survival by interfering both cell cycle independent (mitochondrial Bcl-2) and cycle-dependent (survivin) apoptotic pathways. The COX inhibitors efficiently prevented the cdc2-survivin complex activation by reducing the phosphorylation of cdc2 and c-raf. They modulate the anti-apoptotic effect of bFGF independent of COX II activities. The anti-survivin properties of aspirin and meloxicam in our in vitro model may explain the chemoprevention role of COX inhibitors.