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Modulation of c-raf and cdc2 kinase-suryivin expression: role of cyclo-oxygenase inhibitors in breast cancer apoptosis

  • K. T. Lim
  • S. H. Teh
  • A. D. K. Hill
  • L. Young
  • E. McDermott
  • N. O’Higgins
Session 1 Breast/Endocrine
  • 18 Downloads

Conclusions

These findings suggest aspirin and meloxicam modulate breast cancer cells survival by interfering both cell cycle independent (mitochondrial Bcl-2) and cycle-dependent (survivin) apoptotic pathways. The COX inhibitors efficiently prevented the cdc2-survivin complex activation by reducing the phosphorylation of cdc2 and c-raf. They modulate the anti-apoptotic effect of bFGF independent of COX II activities. The anti-survivin properties of aspirin and meloxicam in our in vitro model may explain the chemoprevention role of COX inhibitors.

Copyright information

© Springer 2002

Authors and Affiliations

  • K. T. Lim
    • 2
  • S. H. Teh
    • 1
  • A. D. K. Hill
    • 2
  • L. Young
    • 2
  • E. McDermott
    • 2
  • N. O’Higgins
    • 2
  1. 1.Mayo ClinicRochesterUSA
  2. 2.Department of SurgerySt Vincent’s University Hospital, University College DublinIreland

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