Abstract
Introduction
The combination of ageing, illness, and medications can lead to hyponatraemia or hypernatraemia.
Aims
To describe the distribution of plasma sodium levels in older patients admitted to hospital.
Methods
We carried out a hospital based cross-sectional study examining 1,511 serum sodium concentrations ([Na+]) among 336 elderly patients and attempted to elucidate the cause(s) of the abnormal serum [Na+].
Results
The study population had a mean age of 81.4. Ninety-two (27.4%) patients had hyponatraemia and seven patients (2.1%) had hypernatraemia during their hospitalisation. The distribution of [Na+] results was towards the lower end of the normal range. The mortality rate of patients with hyponatraemia was 14.1% and that of patients with normal serum [Na+] was 8.9%. Six patients with hypernatraemia died in hospital. Lower respiratory tsuract infection and medication accounted for the majority of cases.
Conclusions
Deranged [Na+] is common among elderly patients admitted to hospital.
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References
Brocklehurst’s Textbook of Geriatric Medicine and Gerontology, 6th Edition, Churchill Livingstone, pp1113–1114.
Terzian, C, Frye, EB, Piotrowski, ZH. Admission hyponatremia in the elderly: Factors influencing prognosis.J Gen Intern Med 1994; 9:89.
Sunderam SG, Manikar GD: Hyponatraemia in the elderly.Age Ageing 1983; 1277–80.
Natkunam A, Shek CC, Swaminathan R Hyponatremia in a hospital population.J Med. 1991;22(2):83–96.
Miller, M, Morley, JE, Rubenstein, LZ. Hyponatremia in a nursing home population.J Am Geriatr Soc 1995; 43:1410–3.
Hochman I, Cabili S, Peer G. Hyponatraemia in internal medicine ward patients: causes, treatment and prognosis.Isr J Med Sci 1989; 25:73–76.
Miller M, Gold GC, Friedlander DA. Physiological changes of aging affecting salt and water balance.Rev Clin Gerant 1991; 1: 215–230.
Phillips, PA, Rolls, BJ, Ledingham, JGG, et al. Reduced thirst after water deprivation in healthy elderly men.N Engl J Med 1984; 311:753.
Dyke, MM, Davis KM, Clark BA, et al. Effects of hypertonicity on water intake in the elderly. An agerelated failure.Geriatr Nephrol Urol 1997; 7:11.
Albert SG, Nakra BRS, Grossberg GT, Cmainal ER. Drinking behaviour and vasopressin responses to hyperosmolality in Alzheimer’s disease.Int Psychogeriatr 1994; 6: 78–86.
Owen JA, Campbell DG. A comparison of plasma electrolyte and urea levels in healthy persons and in hospital patients.Clin Chem Acta 1968; 22: 611–618.
Crowe MJ, Forsling ML, Rolls BJ, Philips PA, Ledingham JG, Smith RF. Altered water excretion in healthy elderly men.Age Aging 1987; 16: 285–293.
Asplind, R, Aberg, H. Diurnal variations in the levels of antidiuretic hormone in the elderly.J Intern Med 1991; 229:131–4.
Snyder, NA, Feigal, DW, Arieff, AI. Hypernatremia in elderly patients.Ann Intern Med 1987; 107:309.
Kleinfeld M, Casimar M, Borra S: Hyponatraemia as observed in a chronic disease facility.J Am Geriatr Soc 1979; 27(4):155–160.
Anderson RJ. Hospital-associated hyponatraemia.Kidney Int 1986; 29:1237–47.
Liu BA, Mittmann N, Knowles SR, Shear NH. Hyponatraemia and the syndrome of inappropriate secretion of antidiuretic hormone associated with the use of selective serotonin reuptake inhibitors: a review of spontaneous reports.Can Med Assoc J 1996; 155: 519–527.
Sharma H, Pompei P. Antidepressant-induced hyponatraemia in the aged. Avoidance and management strategies.Drugs Aging 1996; 8:430–435.
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O’Connor, K.A., Cotter, P.E., Kingston, M. et al. The pattern of plasma sodium abnormalities in an acute elderly care ward: A cross-sectional study. Ir J Med Sci 175, 28–31 (2006). https://doi.org/10.1007/BF03169169
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DOI: https://doi.org/10.1007/BF03169169