Applied Magnetic Resonance

, Volume 29, Issue 1, pp 159–169 | Cite as

A localization method for the measurement of fast relaxing13C NMR signals in humans at high magnetic fields

  • G. Öz
  • P. G. Henry
  • I. Tkáĉ
  • R. Gruetter


Nuclear magnetic resonance (NMR) signals with shortT 1 andT 2, such as the13C signal of glycogen, are difficult to localize in three dimensions without major signal loss. A pulse sequence that accomplishes the spatial localization of1H-decoupled13C NMR signals on a whole-body scanner within the Food and Drug Administration guidelines for specific absorption rates was designed. The method uses an optimized three-dimensional outer volume suppression scheme combined with one-dimensional image-selected in vivo spectroscopy and surface coil detection. The localization performance of the sequence was validated at 4 T with double chambered phantoms and13C magnetic resonance imaging. Localized13C spectra were acquired from human brain and muscle.


Nuclear Magnetic Resonance Nuclear Magnetic Resonance Signal Specific Absorption Rate Outer Compartment Brain Glycogen 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer 2005

Authors and Affiliations

  • G. Öz
    • 1
  • P. G. Henry
    • 1
  • I. Tkáĉ
    • 1
  • R. Gruetter
    • 1
  1. 1.Center for Magnetic Resonance ResearchUniversity of MinnesotaMinneapolisUSA

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