Abstract
Tc-99m-tetrofosmin SPECT was performed on 6 occasions in 4 patients with hypopharyngeal carcinoma, lung carcinoma, esophageal carcinoma and maxillary plasmocytoma and compared with Tl-201 SPECT. All lesions accumulated both Tc-99m-tetrofosmin and Tl-201. Early uptake ratios of Tc-99m-tetrofosmin were about 2 but those of Tl-201 were much higher (more than 3). Washout rates of Tc-99m-tetrofosmin were higher than those of Tl-201. There was a good positive correlation between the early uptake ratio of Tc-99m-tetrofosmin and that of Tl-201. The delayed uptake ratio and washout rate showed poor correlation. In conclusion, early uptakes of both the agents were similar but their retention patterns were different. Tc-99m-tetrofosmin may be used for tumor imaging though more studies are required to evaluate diagnostic accuracy and the significance of delayed images.
References
Kelly JD, Forster AM, Higley B, Archer CM, Booker FS, Canning LR, et al. Technetium-99m-tetrofosmin as a new radiopharmaceutical for myocardial perfusion imaging.J Nucl Med 34: 222–227, 1993.
Jain D, Wackers FJT, Mattera J, McMahon M, Sinusus AJ, Zaret BL. Biokinetics of technetium-99m-tetrofosmin: myocardial perfusion agent: implication for one-day protocol.J Nucl Med 34: 1254–1259, 1993.
Rigo P, Leclercq B, Itti R, Lahiri A, Braat S. Technetium- 99m-tetrofosmin myocardial imaging: a comparison with thallium-201 and angiography.J Nucl Med 35: 587–593, 1994.
Aktolun C, Bayhan H, Kir M. Clinical experience with Tc-99m MIBI imaging in patients with malignant tumors. Preliminary results and comparison with Tl-201.Clin Nucl Med 17: 171–176, 1992.
Waxman AD, Ramanna L, Memsic LD, Forster CE, Silberman AW, Gleischman SH, et al. Thallium scintigraphy in the evaluation of mass abnormality of the breast.J Nucl Med 34: 18–23, 1993.
O’Tauma LA, Treves ST, Larar JN, Packard AB, Kwan AJ, Barnes PD, et al. Thallium-201 versus technetium-99m- MIBI SPECT in evaluation of childhood brain tumors: a within-subject comparison.J Nucl Med 34: 1045–1051, 1993.
Arbab AS, Koizumi K, Araki T. Comparison of uptake mechanisms of Tc-99m-tetrofosmin, Tc-99m-MIBI and Tl-201 in tumor cell lines.KAKU IGAKU (Jpn J Nucl Med) 32: 892, 1995 (abstract).
Maublant J, Veyre A, Platts EA, Pickett RD. Uptake of Tc-99m-tetrofosmin in isolated mitochondria: evidence for an active mechanism. 35: 46–47, 1994 (abstract).
Basoglu T, Sahin M, Coskun C, Koparan A, Bernay I, Erkan L. Technetium-99m-tetrofosmin uptake in malignant lung tumors.Eur J Nucl Med 22: 687–689, 1995.
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Arbab, A.S., Koizumi, K., Arai, T. et al. Application of Tc-99m-tetrofosmin as a tumor imaging agent: Comparison with Tl-201. Ann Nucl Med 10, 271–274 (1996). https://doi.org/10.1007/BF03165405
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DOI: https://doi.org/10.1007/BF03165405