Annals of Nuclear Medicine

, Volume 2, Issue 2, pp 55–58 | Cite as

Chemical properties of technetium-99m-DL-homocysteine, a possible tumor-imaging agent

  • Atsushi Takeda
  • Rensuke Goto
  • Shoji Okada
Original Article


The chemical properties of99mTc-DL-homocysteine (99mTc-Hcy) showing high accumulation in several experimental tumors were investigated. The form of tumor-tropic99mTc-Hcy was a polymeric complex which appeared at void volume on Sephadex G-15 by eluting with 5 mM Hcy. This complex changed into smaller complexes of ca. 600 molecular weight in the presence of 150 mM NaCl and 5 mM Hcy, suggesting that99mTc-Hcy was a complex composed of smaller polymers which are weakly bound together by an ionic bond. The complex showed a negative charge. The Hcy/Tc molar ratio in the complex was approximately 2 and no Sn was detected.

Key words

99mTc-DL-homocysteine DL-homocysteine Chemical property Tumor affinity Tumor-imaging agent 


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Copyright information

© Springer-Verlag 1988

Authors and Affiliations

  • Atsushi Takeda
    • 1
  • Rensuke Goto
    • 1
  • Shoji Okada
    • 1
  1. 1.Department of Radiobiochemistry, School of Pharmaceutical SciencesUniversity of ShizuokaShizuokaJapan

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