Annals of Nuclear Medicine

, Volume 13, Issue 5, pp 281–285 | Cite as

rCBF in neurodegenerative diseases as estimated by the autoradiographic (ARG) method and delayed I-123-IMP studies

  • Leo Garcia Flores
  • Seishi Jinnouchi
  • Shigeki Nagamachi
  • Hiroshi Nakahara
  • Ryuichi Nishii
  • Shigemi Futami
  • Shozo Tamura
Original Article


A total of 24 patients with a mean age of 45.8 ± 20.8 were included in the study. The patients were grouped as Control (C), Degenerative Syndromes (DS), Degeneration Associated with External Factors (DEF), Degeneration Associated with Focal Neurologic Lesion (DFN) and Demyelinating Disease (DM). Imaging started 15 minutes for early and 4 hours for delayed scans after IV infusion of I-123 IMP. The rCBF was calculated by the IMP autoradiographic (ARG) method. The wash-out ratio (WR) was calculated as the ratio of the Delay/Early count. In the rCBF of the various areas of the brain, significant differences were noted between various disease groups. No correlation was noted between rCBF and WR (r = −0.50). The WR of patients grouped according to various disease processes did not show a significant difference between various areas of the brain. In conclusion, the rCBF was effective in separating both various areas of the brain and disease entities. WR from a delayed study is less useful in neurodegenerative diseases.

Key words

iodine-123-IMP ARG method regional cerebral blood flow neurodegenerative disease 


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Copyright information

© Springer-Verlag 1999

Authors and Affiliations

  • Leo Garcia Flores
    • 1
  • Seishi Jinnouchi
    • 1
  • Shigeki Nagamachi
    • 1
  • Hiroshi Nakahara
    • 1
  • Ryuichi Nishii
    • 1
  • Shigemi Futami
    • 1
  • Shozo Tamura
    • 1
  1. 1.Department of RadiologyMiyazaki Medical CollegeMiyazakiJapan

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