Annals of Nuclear Medicine

, Volume 7, Issue 1, pp 39–44 | Cite as

Radioimmunodetection of lung cancer with IMACIS-1, I-131 labeled monoclonal antibodies to CEA and CA19-9

Comparison of accumulations in irradiated and non-irradiated site
  • Tomoko Kazumoto
  • Norio Mitsuhashi
  • Kazushige Hayakawa
  • Ichiro Yonome
  • Hideo Niibe
Original Article


IMACIS-1 is a radiopharmaceutical containing a mixture of Iodine-131 labeled monoclonal antibodies to CEA and CA19-9. IMACIS-1 immunoscintigraphy was evaluated for tumor detection in 7 primary lung cancer and 2 metastatic lung cancer patients who received radiotherapy. No adverse side effects due to IMACIS-1 were observed in this study. Positive detection was achieved in 5 of 9 patients (55.6%). It was less, but nearly the same as the detection rate obtained with Gallium-67 citrate (67Ga-citrate) in these patients. There was no clear correlation between IMACIS-1 accumulation and the CEA or CA19-9 serum levels. The IMACIS-1 positive detection rate decreased in many of the irradiated lesions. We considered that the decreased number of tumor cells and changes in blood perfusion are some of the factors controlling accumulation in tumors.

Key words

immunoscintigraphy IMACIS-1 lung cancer radiotherapy Ga-67 citrate 


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  1. 1.
    Sasaki Y, Inoue T, Mitsuhashi N, et al: Clinical evaluation of immunoscintigraphy with I-131 anti-CEA and I-131 anti-CA19-9 monoclonal antibody cocktail (IMACIS-1)—Report of phase II study—.Jpn J Nucl Med 27: 349–362, 1990Google Scholar
  2. 2.
    Higashi T, Kashima I, Shimura K, et al: Gallium-67 scanning in the evaluation of therapy of malignant tumors of the head and neck.J Nucl Med 18: 243–249, 1977PubMedGoogle Scholar
  3. 3.
    Robert EH, Robert EP, James LQ III: Scanning treated Hodgkin’s disease with Ga-67 citrate.Radiology 110: 151–154, 1974Google Scholar
  4. 4.
    Takahashi T, Tsujino D, Kato Y, et al: Clinical evaluation of immunoscintigraphy using IMACIS-1.J Jpn Soc Cancer Ther 24: 169, 1989Google Scholar
  5. 5.
    Carlos B, Paul BH, Jacob DB, et al: Gallium-67 citrate imaging studies of the lung.Semin Nucl Med 10: 286–301, 1980CrossRefGoogle Scholar
  6. 6.
    Kinoshita F, Ushio T, Maekawa A, et al: Scintiscanning of pulmonary diseases with Ga-67-citrate.J Nucl Med 15: 227–233, 1974PubMedGoogle Scholar
  7. 7.
    Hareyama M, Imai K, Kubo K, et al: Effect of radiation on the expression of carcinoembrionic antigen of human gastric adenocarcinoma cells.Cancer 67: 2269–2274, 1991PubMedCrossRefGoogle Scholar
  8. 8.
    Mitsuhashi N, Yamakawa M, Kazumoto T, et al: Experimental studies on changes of tumor antigenicity by irradiationin vitro.J Jpn Soc Ther Radiol Oncol 1 (Supplement 1): 13, 1989Google Scholar
  9. 9.
    Mitsuhashi N, Takahashi M, Okazaki A, et al: Interactions of radiation and Biological Response Modifiers (BRMs) in the treatment of malignant tumor.Jpn J Cancer Clin 36 (13): 2272–2277, 1990Google Scholar
  10. 10.
    Msirikale JS, Klein JL, Schroeder L, et al: Radiation enhancement of radiolabeled antibody deposition in tumors.Int J Radat Oncol Biol Phys 13: 1839–1844, 1987CrossRefGoogle Scholar
  11. 11.
    Mitsuhashi N, Kazumoto T, Nakayama Y, et al: Experimental study of tumor detection using I-131 labeled F (ab’)2 fragments of monoclonal antibodies to CA19-9 and CEA (IMACIS-1).Jpn J Cancer Clin 35 (15): 1753–1758, 1989Google Scholar
  12. 12.
    Chatal JF, Saccavini JC, Fumoleau P, et al: Immunoscintigraphy of colon carcinoma.J Nucl Med 25: 307–314, 1984PubMedGoogle Scholar
  13. 13.
    Sugiyama S, Furuta M, Suzuki Y, et al: Clinical evaluation of immunoscintigraphy using a cocktail of I-131 labeled anti-CEA and anti-CA19-9 monoclonal antibodies.Image technology & information display 20: 1101–1107, 1988Google Scholar
  14. 14.
    Mitsuhashi N, Niibe H, Yamakawa M, et al: The clinical evaluation of serum CA19-9 and CA12-5 levels in patients with malignant tumors—Comparison with serum CEA levels—.Jpn J Nucl Med 22 (12): 1835–1841, 1985Google Scholar

Copyright information

© Springer-Verlag 1993

Authors and Affiliations

  • Tomoko Kazumoto
    • 1
  • Norio Mitsuhashi
    • 1
  • Kazushige Hayakawa
    • 1
  • Ichiro Yonome
    • 1
  • Hideo Niibe
    • 1
  1. 1.Department of RadiologyGunma University School of MedicineGunmaJapan

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