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Myocardial fatty acid metabolism in diabetic mice with125I-BMIPP

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Abstract

In patients with diabetes mellitus, the existence of diabetic cardiomyopathy was substantiated. This study was undertaken to evaluate the myocardiac fatty acid metabolism of diabetic mice (n = 21) and controls (n = 21) in125I-BMIPP in fasted and unfasted states.125I-BMIPP of 370 kBq was given and thirty minutes later, animals from both groups were killed. Samples of hearts, liver and other organs were removed, weighed and then counted in a scintillation counter. The percent injected dose/g of hearts of diabetic mice was significantly reduced compared to controls in unfasted (p < 0.05) and fasted (p < 0.01) groups. These findings may reflect impaired fatty acid utilization of the hearts in diabetic mice compared to controls.

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Authors and Affiliations

  1. Department of Radiology, Teikyo University School of Medicine, Kaga 2-11-1, Itabashi-ku, 173-8605, Tokyo, Japan

    Motoo Oshima, Shizuka Higashi, Yoshirou Kikuchi, Tatsuo Shirai, Tokuzou Yokokawa, Tatsuro Kaminaga, Hiroshi Yasukochi & Shigeru Furui

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  1. Motoo Oshima
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  2. Shizuka Higashi
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  3. Yoshirou Kikuchi
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  4. Tatsuo Shirai
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  5. Tokuzou Yokokawa
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  6. Tatsuro Kaminaga
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  7. Hiroshi Yasukochi
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  8. Shigeru Furui
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Oshima, M., Higashi, S., Kikuchi, Y. et al. Myocardial fatty acid metabolism in diabetic mice with125I-BMIPP. Ann Nucl Med 12, 133–137 (1998). https://doi.org/10.1007/BF03164777

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  • DOI: https://doi.org/10.1007/BF03164777

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