Myocardial fatty acid metabolism in diabetic mice with125I-BMIPP
- 41 Downloads
In patients with diabetes mellitus, the existence of diabetic cardiomyopathy was substantiated. This study was undertaken to evaluate the myocardiac fatty acid metabolism of diabetic mice (n = 21) and controls (n = 21) in125I-BMIPP in fasted and unfasted states.125I-BMIPP of 370 kBq was given and thirty minutes later, animals from both groups were killed. Samples of hearts, liver and other organs were removed, weighed and then counted in a scintillation counter. The percent injected dose/g of hearts of diabetic mice was significantly reduced compared to controls in unfasted (p < 0.05) and fasted (p < 0.01) groups. These findings may reflect impaired fatty acid utilization of the hearts in diabetic mice compared to controls.
Key wordsmouse diabetes mellitus fatty acid metabolism diabetic cardiomyopathy 125I-BMIPP
Unable to display preview. Download preview PDF.
- 2.Brown AL Jr, Juergens JL. Arteriosclerosis and Atherosclerosis.In: Fairbairn II JF, Juergens JL, Spittell JA, eds.Peripheral Vascular Diseases, fourth ed. Philadelphia, London, Toronto: W.B. Saunders, pp. 159–171, 1972.Google Scholar
- 11.Morishita S, Kusuoka H, Yamamichi Y, Suzuki N, Kurami M, Nishimura T. Kinetics of radioiodinated species in subcellular fractions from rat hearts following administration of iodine-123-labelled 15-(p-iodophenyl)-3-(R,S)-methylpentadecanoic acid (123I-BMIPP).Eur J Nucl Med 23: 383–389, 1996.PubMedCrossRefGoogle Scholar
- 15.Nitenberg A, Valensi P, Sachs R, Dali M, Aptecar E, Attali JR. Impairment of coronary vascular reserve and ACh-induced coronary vasodilation in diabetic patients with angiographically normal coronary arteries and normal left ventricular systolic function.Diabetes 45: 1017–1025, 1993.CrossRefGoogle Scholar
- 20.Opie LH. Fuels: carbohydrates and lipids.In: Opie LH, ed. The Heart (Physiology and Metabolism). New York: Raven Press, pp. 208–246, 1991.Google Scholar