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Annals of Nuclear Medicine

, Volume 12, Issue 3, pp 133–137 | Cite as

Myocardial fatty acid metabolism in diabetic mice with125I-BMIPP

  • Motoo Oshima
  • Shizuka Higashi
  • Yoshirou Kikuchi
  • Tatsuo Shirai
  • Tokuzou Yokokawa
  • Tatsuro Kaminaga
  • Hiroshi Yasukochi
  • Shigeru Furui
Original Article

Abstract

In patients with diabetes mellitus, the existence of diabetic cardiomyopathy was substantiated. This study was undertaken to evaluate the myocardiac fatty acid metabolism of diabetic mice (n = 21) and controls (n = 21) in125I-BMIPP in fasted and unfasted states.125I-BMIPP of 370 kBq was given and thirty minutes later, animals from both groups were killed. Samples of hearts, liver and other organs were removed, weighed and then counted in a scintillation counter. The percent injected dose/g of hearts of diabetic mice was significantly reduced compared to controls in unfasted (p < 0.05) and fasted (p < 0.01) groups. These findings may reflect impaired fatty acid utilization of the hearts in diabetic mice compared to controls.

Key words

mouse diabetes mellitus fatty acid metabolism diabetic cardiomyopathy 125I-BMIPP 

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Copyright information

© Springer-Verlag 1998

Authors and Affiliations

  • Motoo Oshima
    • 1
  • Shizuka Higashi
    • 1
  • Yoshirou Kikuchi
    • 1
  • Tatsuo Shirai
    • 1
  • Tokuzou Yokokawa
    • 1
  • Tatsuro Kaminaga
    • 1
  • Hiroshi Yasukochi
    • 1
  • Shigeru Furui
    • 1
  1. 1.Department of RadiologyTeikyo University School of MedicineTokyoJapan

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