Abstract
This study was undertaken to compare axial images of99mTc-Technegas SPECT (Technegas) with those of133Xe gas dynamic SPECT in patients with pulmonary emphysema. There were 20 patients, 19 males and 1 female. All patients except one ex-smoker were heavy smokers with a mean age of 68.1 years. For Technegas scintigraphy, the patients inhaled 505 MBq99mTc-Technegas in several tidal volume breaths in the supine position without breath holding. For133Xe gas scintigraphy, the patients inhaled 370 MBq133Xe gas.133Xe gas dynamic SPECT was performed in the equilibrium phase for the last minute of the 3 minute inhalation in a closed circuit, and in the washout phase for 6 minutes of inhalation in a semi-closed circuit, by means of a gamma camera with dual detectors (Picker model Prism 2000). Abnormal findings included heterogeneity, defects and hot spots on Technegas images and on retention images taken 3 minutes after133Xe gas washout. In 2 of 20 patients, the degree of abnormal findings on Technegas images depended on the area of133Xe gas retention in the washout phase. In 3 patients, the degrees of abnormal findings on both Technegas SPECT and133Xe gas dynamic SPECT images were equivalent. In the remaining 15 patients, more detailed findings and a greater area were shown by Technegas SPECT than133Xe gas dynamic SPECT. We conclude that in patients with pulmonary emphysema Technegas SPECT can demonstrate ventilation impairment more easily than133Xe gas dynamic SPECT.
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Burch WM, Sullivan PJ, McLaren CJ. Technegas: a new Ventilation agent for lung scanning.Nucl Med Commun 7: 865–871, 1986.
Peltier P, Faucal P, Chetanneau A, Chatal JF. Comparison of technetium-99m aerosol and krypton-81m in ventilation studies for the diagnosis of pulmonary embolism.Nucl Med Commun 11: 631–638, 1990.
Rimkus DS, Ashburn WL. Lung ventilation scanning with a new carbon particle radioaerosol (Technegas). Preliminary patient studies.Clin Nucl Med 15: 222–226, 1990.
Amis TC, Crawford ABH, Davison A, Engel LA. Distribution of inhaled99mTechnetium labeled ultrafine carbon particle aerosol (Technegas) in human lungs.Eur Respir J 3: 679–685, 1990.
Crawford ABH, Davison A, Amis TC, Engel LA. Intrapulmonary distribution of99mTechnetium labeled ultrafine carbon aerosol (Technegas) in severe airflow obstruction.Eur Respir J 3: 686–692, 1990.
Isawa T, Teshima T, Anazawa Y, Miki M, Motomiya M. Technegas for inhalation lung imaging.Nucl Med Commun 12: 47–55, 1991.
Peltier P, Bardies M, Chetanneau A, Chatal JF. Comparison of technetium-99m C and phytate aerosol in ventilation studies.Eur J Nucl Med 19: 349–354, 1992.
James JM, Lloyd JJ, Leahy BC, Church S, Hady CC, Shields RA, et al.99Tcm Technegas and krypton-81m ventilation scintigraphy: a comparison in known respiratory disease.Br J Radiol 65: 1075–1082, 1992.
Satoh K, Tanabe M, Nakano S, Nishiyama Y, Takahashi K, Kobayashi T, et al. Comparison of99mTc-Technegas scintigraphy and high resolution CT in pulmonary emphysema.KAKU IGAKU (Jpn J Nucl Med) 32: 487–494, 1995. (Japanese, abstract in English)
Zhang X, Hirano H, Yamamoto K, Kusaka Y, Sugimoto K, Kimoto T, et al. Technegas ventilation SPECT for evaluating silicosis in comparison with computed tomography.Ann Nucl Med 10: 165–170, 1996.
Suga K, Nishigauchi K, Kume N, Koike S, Takano K, Tokuda O, et al. Dynamic pulmonary SPECT of Xe-133 gas washout.J Nucl Med 37: 807–814, 1996.
Suzuki T. Evaluation of the regional lung function revealed in radioaerosol scintigram of chronic obstructive pulmonary disease. I. The comparison of radioaerosol scintigram with the lung function tests in chronic obstructive pulmonary disease.Nippon Acta Radiologica 40: 156–167, 1980. (Japanese, abstract in English)
Secker-Walker RH, Hill RI, Markham J. The measurement of regional ventilation in man: a new method of quantitation.J Nuc Med 14: 725–732, 1973.
Schor RA, Shames DM, Weber PM, Dos Remedios LV. Regional ventilation studies with81mKr and133Xe: a comparative analysis.J Nucl Med 19: 348–353, 1987.
Alderson PO, Secker-Walker RH, Forrest JV. Detection of obstructive pulmonary disease. Relative sensitivity of ventilation-perfusion studies and chest radiography.Radiology 111: 643–648, 1974.
Alderson PO, Lee H, Summer WR, Motazedi A, Wagner HN. Comparison of Xe-133 washout and single-breath imaging for the detection of ventilation abnormalities.J Nucl Med 20: 917–922, 1979.
Bunow B, Line BR, Horton MR, Weiss GH. Regional ventilatory clearance by xenon scintigraphy: a critical evaluation of two estimation procedure.J Nucl Med 20: 703–710, 1979.
Van der Mark TW, Peset R, Beekhuis H. An improved method for analysis of133Xe washin and washout curves.J Nucl Med 21: 1029–1034, 1980.
Sirr SA, Junenemann PJ, Tom H, Boudreau RJ, Chandler RP, Loken MK. Effect of ethanol on droplet size, efficiency of delivery, and clearance characteristics of technetium-99m DTPA aerosol.J Nucl Med 26: 643–646, 1985.
Murata K, Itoh H, Todo G. Centrilobular lesions of the lung: demonstration by high-resolution CT and pathologic correlation.Radiology 161: 641–645, 1986.
Webb WR, Stein MG, Finkbeiner WE, Im JG, Lynch D, Gamsu G. Normal and diseased isolated lungs: high-resolution CT.Radiology 166: 81–87, 1988.
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Satoh, K., Takahashi, K., Sasaki, M. et al. Comparison of99mTc-Technegas SPECT with133Xe dynamic SPECT in pulmonary emphysema. Ann Nucl Med 11, 201–206 (1997). https://doi.org/10.1007/BF03164764
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DOI: https://doi.org/10.1007/BF03164764