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Evaluation of the brain uptake properties of [1-11C]labeled hexanoate in anesthetized cats by means of positron emission tomography

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Abstract

Positron emission tomography (PET) was performed on the cat brain to characterize [1-11C]hexanoate and other [1-11C]labeled short and medium-chain fatty acids as a tracer of fatty acid oxidative metabolism. After an intravenous injection the brain uptake of [1-11C]hexanoate reached a peak followed by rapid washout until 2 min (first phase). Subsequently the total brain uptake was again increased and reached to a peak 7–10 min after tracer injection (second phase). The blood radioactivity of unmetabolized [1-11C]hexanoate was rapidly decreased and almost eliminated within the first 2 min, whereas the blood radioactivity of [11C]CO2/HCO3 − was gradually increased and reached a peak approximately 5 min after tracer injection. As the effect of circulating [11C]CO2/ HCO3 − was examined by a bolus intravenous injection of [11C]CO2/HCO3 −, the brain uptake of [11C]CO2/HCO3 − was rapidly increased right after the injection and changed parallel to the blood level of [11C]CO2/HCO3 −.

These results suggest that, in contrast to the previous mouse data, the time-activity curve in the cat brain following intravenous injection of [l-11C]hexanoate has a biphasic pattern, the second phase being determined by peripherally originating [11C]CO2/HCO3 −, and therefore does not reflect the metabolism of11C-labeled fatty acid in the brain.

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Authors and Affiliations

  1. Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, 1-1 Naka-cho, Itabashi-ku, 173, Tokyo, Japan

    Yojiro Sakiyama, Kiichi Ishiwata, Kenji Ishii, Keiichi Oda, Hinako Toyama, Shin-ichi Ishii & Michio Senda

  2. Department of the Autonomic Nervous System, Tokyo Metropolitan Institute of Gerontology, Japan

    Yojiro Sakiyama, Hitomi Nakayama & Akio Sato

Authors
  1. Yojiro Sakiyama
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  2. Kiichi Ishiwata
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  3. Kenji Ishii
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  4. Keiichi Oda
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  5. Hinako Toyama
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  6. Shin-ichi Ishii
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  7. Hitomi Nakayama
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  8. Akio Sato
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  9. Michio Senda
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Sakiyama, Y., Ishiwata, K., Ishii, K. et al. Evaluation of the brain uptake properties of [1-11C]labeled hexanoate in anesthetized cats by means of positron emission tomography. Ann Nucl Med 10, 361–366 (1996). https://doi.org/10.1007/BF03164748

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  • DOI: https://doi.org/10.1007/BF03164748

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