Annals of Nuclear Medicine

, Volume 6, Issue 4, pp 253–260 | Cite as

Single photon emission computed tomography using201Tl chloride in pulmonary nodules: Comparison with67Ga citrate and99mTc-labeled hexamethyl-propyleneamine-oxime

  • Kazuo Itoh
  • Hironori Takekawa
  • Eriko Tsukamoto
  • Kazuhiko Nagao
  • Kunihiro Nakada
  • Shosaku Abe
  • Yoshikazu Kawakami
  • Masayori Furudate
Original Article


A single photon emission computed tomography (SPECT) with201Tl chloride (Tl-201) was carried out prospectively in 50 patients with pulmonary nodules and its diagnostic value was compared with those of67Ga citrate (Ga-67) and99mTc-labeled hexamethyl-propyleneamineoxime (Tc-99m-HMPAO). Tl-201 SPECT provided 88% (early)–91% (delayed) sensitivity, 85% (early and delayed) specificity and 87% (early)–89% (delayed) accuracy. The sensitivity of the Tl-201 planar image was 56 (early)–62% (delayed), which was significantly lower than that of SPECT. Delayed SPECT images at 2 hour postinjection were more preferable to disclose the malignant pulmonary nodule than early SPECT images at 15 minutes postinjection. The application of SPECT with Ga-67 failed to improve the sensitivity of planar imaging for malignant pulmonary nodules. Tc-99m-HMPAO was concentrated in 62% of 13 patients with malignant pulmonary nodules, which was slightly higher than Ga-67 in 54% of 28 patients. In an analysis of the histologic types of lung cancer, the sensitivity of Tl-201 was not significantly different in all types. On the other hand, Ga-67 was positive only in 25% of 12 patients with adenocarcinoma.

A combination of SPECT and Tl-201 is the best choice among routine scintigraphic techniques for depicting malignant pulmonary nodules. The Tl-201 SPECT image may play a complementary role in the characterization of pulmonary nodules which are revealed on a plain radiograph and computed tomography.

Key words

single photon emission computed tomography (SPECT) 201T1 chloride 67Ga citrate 99mTc-hexamethyl-propyleneamine-oxime lung cancer 


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Copyright information

© Springer-Verlag 1992

Authors and Affiliations

  • Kazuo Itoh
    • 1
  • Hironori Takekawa
    • 2
  • Eriko Tsukamoto
    • 1
  • Kazuhiko Nagao
    • 1
  • Kunihiro Nakada
    • 1
  • Shosaku Abe
    • 2
  • Yoshikazu Kawakami
    • 2
  • Masayori Furudate
    • 1
  1. 1.Department of Nuclear MedicineHokkaido University School of MedicineSapporoJapan
  2. 2.First Department of Internal MedicineHokkaido University School of MedicineJapan

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