The aim of this prospective study is to evaluate the availability of preoperative perfusion SPECT in predicting postoperative pulmonary function following resection. Twenty-three patients with lung cancer who were candidates for lobectomy were investigated preoperatively with spirometry, x-ray computed tomography and99mTc macroaggregated albumin SPECT. Their postoperative pulmonary functions were predicted with these examinations. The forced vital capacity and the forced expiratory volume in one second were selected as parameters for overall pulmonary function. The postoperative pulmonary function was predicted by the following formula: Predicted postoperative value=observed preoperative value × precent perfusion of the lung not to be resected. The patients were reinvestigated with spirometry at 3 months and 6 months after lobectomy, and the values obtained were statistically compared with the predicted values. Close relationships were found between predicted and observed forced vital capacity (r=0.87, p < 0.001), and predicted and observed forced expiratory volume in one second (r=0.90, p < 0.001). The accurate prediction of pulmonary function after lobectomy could be achieved by means of lung perfusion SPECT.
lung perfusion SPECT prediction pulmonary function lung cancer
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Bria WF, Kanarek DJ, Kazemi H: Prediction of postoperative pulmonary function following thoracic operations.J Thorac Cardiovasc Surg 86: 186–192, 1983PubMedGoogle Scholar
Kristersson S, Lindell SE, Svanberg L: Prediction of pulmonary function loss due to pneumonectomy using Xe-133 radiospirometry.Chest 62: 694–698, 1972PubMedCrossRefGoogle Scholar
Olsen GN, Block AJ, Tobias JA: Prediction of postpneumonectomy pulmonary function using quantitative macroaggregate lung scanning.Chest 66: 13–16, 1974PubMedCrossRefGoogle Scholar
Wernly JA, DeMeester TR, Kirchner PT, et al: Clinical value of quantitative ventilation-perfusion lung scans in the surgical management of bronchogenic carcinoma.J Thorac Cardiovasc Surg 80: 535–543, 1980PubMedGoogle Scholar
Ali MK, Mountain CF, Ewer MS, et al: Predicting loss of pulmonary function after pulmonary resection for bronchogenic carcinoma.Chest 77: 337–342, 1980PubMedCrossRefGoogle Scholar
Ali MK, Ewer MS, Atallah MR, et al: Regional and overall pulmonary function changes in lung cancer.J Thorac Cardiovasc Surg 86: 1–8, 1983PubMedGoogle Scholar
Boysen PG, Harris JO, Block AJ, et al: Prospective evaluation for pneumonectomy using perfusion scanning.Chest 80: 163–168, 1981PubMedCrossRefGoogle Scholar
Moldofsky PJ, Rubenstein JH, Richten MP, et al: Quantitative lung scans for prediction of post-radiotherapy pulmonary function.Clin Nucl Med 13: 644–646, 1988PubMedCrossRefGoogle Scholar
Narabayashi I, Suematsu T, Suematsu C: Assessment of SPECT ventilation-perfusion imaging in patients with lung cancer.Eur J Nucl Med 12: 329–332, 1986PubMedCrossRefGoogle Scholar