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Neurochemical Pathology

, Volume 8, Issue 3, pp 181–187 | Cite as

Antibodies to glycoconjugates in human motor neuron disease

  • Norman Latov
  • Arthur P. Hays
  • Robert K. Yu
  • Hiroaki Ito
  • Florian P. Thomas
Original Articles
  • 13 Downloads

Abstract

IgM monoclonal gammopathy has been reported in some patients with motor neuron disease. The monoclonal IgMs in several of the patients bind to the carbohydrate epitope Gal (β1–3) GalNAc, which is shared by gangliosides GM1 and GD1b and glycoproteins in the nervous system and crossreacted with Gal (β1–3) G1cNAc. They also immunostain spinal cord and gray matter and presynaptic terminals of motor neurons at the neuromuscular junction. The role and mechanisms of action of these antibodies in motor neuron disease is under investigation.

Index Entries

Motor neurons, degeneration of autoimmune mechanisms monoclonal antibodies glycolipids and gangliosides 

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Copyright information

© Humana Press 1988

Authors and Affiliations

  • Norman Latov
    • 1
  • Arthur P. Hays
    • 2
  • Robert K. Yu
    • 3
  • Hiroaki Ito
    • 1
  • Florian P. Thomas
    • 1
  1. 1.Departments of Neurology and PathologyColumbia University, College of Physicians and SurgeonsNew York
  2. 2.Division of NeuropathologyColumbia University, College of Physicians and SurgeonsNew York
  3. 3.Department of NeurologyYale University, School of MedicineNew Haven

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