Area-specific modification of acetylcholinesterase activity following 3-mercaptopropionic acid-induced seizures
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Acetylcholinesterase activity (AChE) was assayed in rat CNS membrane fractions after administration of the convulsant 3-mercaptopropionic acid (150 mg/kg, ip). In comparison with saline-injected controls, total AChE activity decreased 12–20% in striatum and cerebellum during seizure and postseizure but failed, to change in cerebral cortex. Specific AChE activity, assayed in the presence of 10−4 M ethopropazine (a butyrylcholinesterase inhibitor) decreased 15–25% in striatum and cerebellum, increased 20–45% in hippocampus, but remained unchanged in cerebral cortex. Saline injection alone increased AChE activity in striatum (68%) and cerebellum (36%) but failed to modify enzyme activity in hippocampus and cerebral cortex. To conclude, AChE sensitivity to convulsant, and saline administration is tissue-specific and not restricted to cholinergic areas.
Index EntriesAcetylcholinesterase seizures 3-mercaptopropionic acid striatum cerebellum hippocampus saline injection convulsant
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