Molecular and Chemical Neuropathology

, Volume 18, Issue 1–2, pp 15–26 | Cite as

Brain Levels of neuropeptide Y in experimental pneumococcal meningitis

  • Martin G. Täuber
  • Donna Ferriero
  • Stephen L. Kennedy
  • R. Ann Sheldon
  • Luis Guerra-Romero
Original Articles


Neuropeptide Y (NPY), which is found in high concentrations in several regions of the brain including nuclei of the brain stem and in nerve fibers surrounding cerebral vessels, has been proposed to play a role in regulating cerebral blood flow (CBF) and systemic vegetative functions. Since CBF is altered during meningitis, we examined whether NPY concentrations changed in various regions of the rabbit brain in response to experimental pneumococcal meningitis. Changes were most pronounced in the medulla, where NPY concentration increased threefold after 48 h of infection. Concomitantly, there was an increase in NPY immunoreactive fibers surrounding small vessels in the dorsolateral medulla, especially in the nucleus tractus solitarius. These results suggest that NPY may play a role in inducing some of the hemodynamic changes seen during pneumococcal meningitis.

Index Entries

Meningitis neuropeptide Y neurotransmitter cerebrospinal fluid Streptococcus pneumoniae infection nucleus tractus solitarius 


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Copyright information

© Humana Press 1993

Authors and Affiliations

  • Martin G. Täuber
    • 1
    • 3
  • Donna Ferriero
    • 2
    • 4
    • 5
  • Stephen L. Kennedy
    • 1
  • R. Ann Sheldon
    • 2
    • 4
  • Luis Guerra-Romero
    • 1
    • 3
  1. 1.Microbial Pathogenesis UnitSan Francisco General HospitalSan Francisco
  2. 2.Neurology ServiceSan Francisco General HospitalSan Francisco
  3. 3.Department of MedicineUniversity of CaliforniaSan Francisco
  4. 4.Department of NeurologyUniversity of CaliforniaSan Francisco
  5. 5.Department of PediatricsUniversity of CaliforniaSan Francisco

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