Molecular and Chemical Neuropathology

, Volume 13, Issue 1–2, pp 119–128 | Cite as

Modification of malathion induced neurochemical changes by adrenalectomy in rats

  • M. A. Matin
  • Seema Sattar
  • K. Husain
Original Articles


The neurochemical changes induced by malathion, an organophosphate compound, were determined in rats. Maximal changes were found in the brain 2 h after the administration of malathion in a dose of 500 mg/kg ip. The activities of cholinesterase and succinic dehydrogenase were reduced whereas those of glycogen phosphorylase, phosphoglucomutase, and hexokinase were increased; the lactate content of brain was also increased. In malathion treated adrenalectomized animals, changes in the activities of cerebral cholinesterase and succinic dehydrogenase were still present; other changes were, however, abolished by adrenalectomy. Activities of certain enzymes, glucose-6-phosphatase, glucose-6-phosphate dehydrogenase, and lactate dehydrogenase were not significantly altered by malathion in normal or adrenalectomized animals. The results indicate that cerebral cholinergic mechanism in malathion treated animals was not modified by adrenalectomy which, however, abolished or reduced changes in the activities of certain glycolytic and glycogenolytic enzymes that are involved in the utilization or metabolism of glucose. The brain lactate content in malathion treated adrenalectomized animals was, also, not significantly different from the control values, suggesting the modification of induced changes by adrenalectomy.

Index Entries

Glycogen glycogen phosphorylase phosphoglucomutase adrenals cholinesterase hexokinase adrenalectomy glucose-6-phosphate pyruvate lactate lactate dehydrogenase glucose-6-phosphate dehydrogenase 


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Copyright information

© Humana Press 1990

Authors and Affiliations

  • M. A. Matin
    • 1
  • Seema Sattar
    • 1
  • K. Husain
    • 1
  1. 1.Industrial Toxicology Research CentreLucknowIndia

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