Netherlands Heart Journal

, Volume 16, Issue 10, pp 359–362 | Cite as

Heaven can wait - or down to earth in real time

Near-death experience revisited
Medica Antiqua
medical history near-death experience hibernation 


Near-death experience (NDE) is an intriguing phenomenon that invites more questions than answers. Hitherto emphasis has been laid on apparent similarities in accounts of NDE to prove a supernatural origin while in fact unique differences besides gross similarities support a neurophysiological explanation. A teleological approach is suggested to explain the neuroprotective strategies involved and accordingly a forme fruste of the biological concept of hibernation is put forward as an unifying hypothesis for clarification. (Neth Heart J 2008;16:359-62.)



Lieda Jagers, BSL.


  1. 1.
    Van Lommel P, van Wees R, Meyers V, Elfferich I. Near-death experience in survivors of cardiac arrest: a prospective study in the Netherlands. Lancet 2001;358:2039-45.Google Scholar
  2. 2.
    Athappilly GK, Greyson B, Stevenson I. Do Prevailing Societal Models Influence Reports of Near-Death Experiences?: A Comparison of Accounts Reported Before and After 1975. J Nerv Ment Dis 2006;194:218-22Google Scholar
  3. 3.
    Plato. The Republic, Book X, (translated by Jowett B), 360 BC. http://classics
  4. 4.
    Bede. A history of the English Church and people (translated by Sherley-Price L.) Penguin classics. 1955.Google Scholar
  5. 5.
    Jones DG. Excerpts from Recollections of an Old Soldier: The Life of Captain David Perry. Combined electronic edition, 1998. (Derived from first edition, Windsor, Vermont, 1822, and subsequent other editions.)
  6. 6.
    Morse M, Castillo P, Venecia D, Milstein J, Tyler DC. Childhood near-death experiences. Am J Dis Child 1986;140:1110-4Google Scholar
  7. 7.
    Joseph R. The Limbic System and the Soul: Evolution and the neuro-anatomy of Religious Experience. Zygon 2001;36:105-36.Google Scholar
  8. 8.
    Semendeferi K, Damasio H, Frank R, Van Hoesen GW. The evolution of the frontal lobes: a volumetric analysis based on three-dimensional reconstructions of magnetic resonance scans of human and ape brains. J Hum Evol 1997;32:375-88.Google Scholar
  9. 9.
    Britton WB,Bootzin RR. Research Report Near-Death Experiences and the Temporal Lobe. Psychol Sci 2004;15:254-58.Google Scholar
  10. 10.
    Morse ML, Venecia Jr D, Milstein J. Near-death experiences: a neuro-physiologic explanatory model. J Near-Death Studies 1989;8:45-53.Google Scholar
  11. 11.
    Merabet LB, Maguire D, Warde A, Alterescu K, Stickgold R, Pascual-Leone A. Visual hallucinations during prolonged blindfolding in sighted subjects. J Neuroophtalmol 2004;24:109-13.Google Scholar
  12. 12.
    Ainslie PN, Poulin MJ. Ventilatory, cerebrovascular, and cardiovascular interactions in acute hypoxia: regulation by carbon dioxide. J Appl Physiol 2004; 97:149-59.Google Scholar
  13. 13.
    Hudetz AG. The cerebral microcirculation in ischemia and hypoxemia. The Arisztid G.B. Kovach Memorial Lecture. Adv Exp Med Biol 2003;530:347-57.Google Scholar
  14. 14.
    Kaneko M, White S, Homan J, Richardson B. Cerebral blood flow and metabolism in relation to electrocortical activity with severe umbilical cord occlusion in the near-term ovine fetus. Am J Obstet Gynaecol 2003;188:961-72.Google Scholar
  15. 15.
    Nogradi A, Domoki F, Degi R, Borda S, Pakasi M, Szabo A, et al. Up-regulation of cerebral carbonic anhydrase by anoxic stress in piglets. J Neuro-chem 2003;85:843-50.Google Scholar
  16. 16.
    Barbiro-Michaely E, Tolmasov M, Rinkevich-Shop S, Sonn J, Mayevsky A. Can the “brain-sparing effect” be detected in a small-animal model? Med Sci Monit 2007;13:211-9.Google Scholar
  17. 17.
    Ross AP, Christian SL, Zhao HW, Drew KL. Persistent tolerance to oxygen and nutrient deprivation and N-methyl-D-aspartate in cultured hippocampal slices from hibernating Arctic ground squirrel. J Cereb Blood Flow Metab 2006;26:1148-56.Google Scholar
  18. 18.
    Zhao HW, Ross AP, Christian SL, Buchholz JN, Drew KL. Decreased NR1 phosphorylation and decreased NMDAR function in hibernating Arctic ground squirrels. J Neurosci Res 2006;84:291-8.Google Scholar

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© Bohn Stafleu van Loghum 2008

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