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Regenerative cell therapy and pharmacotherapeutic intervention in heart failure

Part 2: Pharmacological targets, agents and intervention perspectives

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Abstract

Regenerative medicine represents a promising perspective on therapeutic angiogenesis in patients with cardiovascular disease, including heart failure. However, previous or ongoing clinical trials show ambiguous outcomes with respect to the benefit of regenerative therapy by means of bone marrow stem cell infusion in myocardial infarction patients. Therefore, it is necessary to set up a rational therapeutic strategy in the treatment of congestive heart failure. Chemokines, cytokines and growth factors, as well as pharmaceutical agents, may have an impact on endothelial progenitor cell (EPC) physiology and thus can provide targets for pharmacological intervention. Indeed, EPCs and stem cell niches both in bone marrow and myocardial tissue can be treated as an integral target for recruitment of EPCs from the bone marrow to the cardiac ischaemic niche. In this article, we individually place the signalling factors in their specified context, and explain their roles in the various phases of neovascularisation (see Part 1). (Neth Heart J 2008;16:337-43.)

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    W. H. van Gilst

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  1. C. Qian
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  2. R. G. Schoemaker
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  3. W. H. van Gilst
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  4. B. Yu
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  5. A. J. M. Roks
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Correspondence to W. H. van Gilst.

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Department of Experimental Cardiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands

Institue of Cardiovascular center, The Second Affiliated Hospital of Harbin Medical University, China

Department of Internal medicine, Division of Vascular Pharmacology & Metabolic Diseases, Erasmus MC, Rotterdam, the Netherlands

Correspondence to: W.H. van Gilst, Department of Experimental Cardiology, University Medical Center Groningen, University of Groningen, PO Box 30.001, 9700 RB Groningen, the Netherlands

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Qian, C., Schoemaker, R.G., van Gilst, W.H. et al. Regenerative cell therapy and pharmacotherapeutic intervention in heart failure. NHJL 16, 337–343 (2008). https://doi.org/10.1007/BF03086175

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