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Huisarts en Wetenschap

, Volume 48, Issue 13, pp 12–13 | Cite as

ASCOT-resultaten overtuigen niet

  • EP Walma
  • S Thomas
Commentaar
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Samenvatting

In de ASCOT-BPLA-trial worden amlodipine en perindopril vergeleken met atenolol en het diureticum bendroflumethiazide; volgens de auteurs zouden de nieuwere bloeddrukmiddelen beter zijn dan de klassieke middelen.1

antihypertensiva commentaar geneesmiddelen hart- en vaatziekten hypertensie 

Literatuur

  1. Dahlöf B, Sever PS, Poulter NR, Wedel H, Beevers DG, Caulfield M, et al., for the ASCOT investigators. Prevention of cardiovascular events with an antihypertensive regimen of amlodipine adding perindopril as required versus atenolol adding bendroflumethiazide as required, in the Anglo-Scandinavian Cardiac Outcomes Trial-Blood Pressure Lowering Arm (ASCOT-BPLA): a multicentre randomised controlled trial. Lancet 2005;366:895-906.CrossRefPubMedGoogle Scholar
  2. The ALLHAT Officers and Coordinators for the ALLHAT Collaborative Research Group. Major outcomes in high-risk hypertensive patients randomized to angiotensin-converting enzyme inhibitor or calcium channel blocker vs diuretic. The antihypertensive and lipid-lowering treatment to prevent heart attack trial (ALLHAT). JAMA 2002;288:2981-97.Google Scholar
  3. Carlberg B, Samuelsson O, Lindholm LH. Atenolol in hypertension: is it a wise choice? Lancet 2004;364:1684-9.CrossRefPubMedGoogle Scholar
  4. Neal B, MacMahon S, Chapman N. Blood Pressure Lowering Treatment Trialists' Collaboration. Effects of ACE-inhibitors, calcium antagonists, and other blood pressure-lowering drugs: results of prospectively designed overviews of randomised trials. Lancet 2000;356:1955-64.CrossRefPubMedGoogle Scholar
  5. Pahor M, Psaty B, Alderman MH, Applegate WB, Williamson WD, Cavazinni C, Furberg C. Health outcomes associated with calcium antagonists compared with other first-line antihypertensive therapies: a meta-analysis of randomised trials. Lancet 2000;356:1949-54.CrossRefPubMedGoogle Scholar

Copyright information

© Bohn Stafleu van Loghum 2005

Authors and Affiliations

  1. 1.

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