Skip to main content
SpringerLink
Log in

Overgevoeligheid en verslaving

  • Artikelen
  • Published:
Neuropraxis

Abstract

Recent dierexperimenteel onderzoek heeft aangetoond dat blootstelling aan verslavende stoffen, te weten alcohol, nicotine, heroïne, cocaïne en amfetamine, leidt tot langdurige veranderingen van de prikkeloverdracht in het motivationeel (mesocorticolimbisch) systeem van de hersenen, waardoor er een blijvende overgevoeligheid ontstaat voor de effecten van deze psychoactieve stoffen en voor aan het gebruik geassocieerde omgevingsstimuli (cues).

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figuur 1
Figuur 2

Similar content being viewed by others

Literatuur

  • Barlett E., Hallin A., Chapman B. & Angrist B. (1997). Selective sensitization to the psychosis-inducing effects of cocaine: a possible marker for addiction relapse vulnerability? Neuropsychopharmacology 16, 77-82.

    Google Scholar 

  • Berke J.D. & Hyman S.E. (2000). Addiction, dopamine, and the molecular mechanisms of memory. Neuron 25, 515-532.

    Google Scholar 

  • De Vries T.J., Schoffelmeer A.N.M., Binnekade R., Mulder A.H. & Vanderschuren L.J.M.J. (1998). Drug-induced reinstatement of heroin- and cocaine-seeking behaviour following long-term extinction is associated with expression of behavioural sensitization. Eur. J. Neurosci. 10, 3565-3571.

    Google Scholar 

  • De Vries T.J., Schoffelmeer A.N.M., Binnekade R. & Vanderschuren L.J.M.J. (1999). Dopaminergic mechanisms mediating the incentive to seek cocaine and heroin following long-term withdrawal of i.v. drug self-administration. Psychopharmacology 143, 254-260.

    Google Scholar 

  • Holland P.C. & Gallagher M. (1999) Amygdala circuitry in attentional and representational processes. Trends Cognit. Sci. 3, 65-73.

    Google Scholar 

  • Kalivas P.W. (1993). Neurotransmitter regulation of dopamine neurons in the ventral tegmental area. Brain Res. Rev. 18, 75-113.

    Google Scholar 

  • Kalivas P.W., Churchill L. & Klitenick M.A. (1993). The circuitry mediating the translation of motivational stimuli into adaptive motor responses. In: Kalivas, P.W. & Barnes, C.D. (eds) Limbic motor circuits and neuropsychiatry. CRC Press, Boca Raton, p. 237-287.

  • Kalivas P.W. & Stewart J. (1991). Dopamine transmission in the initiation and expression of drug- and stress-induced sensitization of motor activity. Brain Res. Rev. 16, 223-244.

    Google Scholar 

  • Kelley A.E. (1999). Neural integrative activities of nucleus accumbens subregions in relation to learning and motivation. Psychobiology 27, 198-213.

    Google Scholar 

  • Koob G.F. (1992). Drugs of abuse: anatomy, pharmacology and function of reward pathways. Trends Pharmacol. Sci. 13, 177-184.

    Google Scholar 

  • Markou A., Weiss F., Gold L.H., Caine S.B., Schulteis G. & Koob G.F. (1993). Animal models of drug craving. Psychopharmacology 112, 163-182.

    Google Scholar 

  • Nestby P., Vanderschuren L.J.M.J., De Vries T.J., Hogenboom F., Wardeh G., Mulder A.H. & Schoffelmeer A.N.M. (1997). Ethanol, like psychostimulants and morphine, causes long-lasting hyperreactivity of dopamine and acetylcholine neurons of rat nucleus accumbens: possible role in behavioural sensitization. Psychopharmacology 133, 69-76.

    Google Scholar 

  • Nestby P., Vanderschuren L.J.M.J., De Vries T.J., Mulder A.H., Wardeh G., Hogenboom F. & Schoffelmeer A.N.M. (1999). Unrestricted free-choice ethanol self-administration in rats causes long-term neuroadaptations in the nucleus accumbens and caudate putamen. Psychopharmacology 141, 307-314.

    Google Scholar 

  • Pierce R.C. & Kalivas P.W. (1997). A circuitry model of the expression of behavioral sensitization to amphetamine-like psychostimulants. Brain Res. Rev. 25, 192-216.

    Google Scholar 

  • Robins T.W. & Everitt B.J. (1996). Neurobehavioural mechanisms of reward and motivation. Curr. Opinion Neurobiol. 6, 228-236.

    Google Scholar 

  • Robinson T.E. & Berridge K.C. (1993). The neural basis of drug craving: an incentive- sensitization theory of addiction. Brain Res. Rev. 18, 247-291.

    Google Scholar 

  • Strakowski S.M., Sax K.W., Setters M.J. & Keck P.E. (1996). Enhanced response to repeated d-amphetamine chalenge: evidence for Behavioral sensitization in humans. Biol. Psychiatry 40, 872-880.

    Google Scholar 

  • Vanderschuren L.J.M.J. & Kalivas P.W. (2000). Alterations in dopaminergic and glutamatergic transmission in the induction and expression of behavioral sensitization: a critical review of preclinical studies. Psychopharmacology 151, 99-120.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. www.bsl.nl/shop/neuropraxis-1387-5817.html

    Ton Schoffelmeer

Authors
  1. Ton Schoffelmeer
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Schoffelmeer, T. Overgevoeligheid en verslaving. NEPR 4, 134–138 (2000). https://doi.org/10.1007/BF03078982

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF03078982

Search

Navigation