Pesticides, lead and solvents: Pregnancy outcome and fertility

For daily practice


The effect of occupational hazards on reproductive health is a rapidly growing and evolving field of research. Reproductive health is a major aspect of human life, and different types of reproductive failures are common. Pesticides, inorganic lead and organic solvents are among the most extensively studied occupational reproductive toxicants. In this review, we focus on the reproductive effects of these chemicals.

pesticides, solvents, lead, pregnancy outcome, fertility, occupational exposure 


  1. Lähdetie J. Occupation- and exposure-related studies on human sperm. J Occup Environ Med 1995; 37: 922–930.CrossRefPubMedGoogle Scholar
  2. Nurminen T. Maternal pesticide exposure and pregnancy outcome. J Occup Environ Med 1995; 37: 935–940.CrossRefPubMedGoogle Scholar
  3. García A. Occupational exposure to pesticides and congenital malformations: A review of mechanisms, methods, and results. Am J Ind Med 1998; 33: 232–240.CrossRefPubMedGoogle Scholar
  4. Cock J de, Westweer K, Heederik D, et al. Time to pregnancy and occupational exposure to pesticides in fruit growers in the Netherlands. Occup Environ Med 1994; 51: 693–699.CrossRefPubMedGoogle Scholar
  5. Sallmén M, Liesivuori J, Taskinen H, et al. Time to pregnancy among the wives of Finnish greenhouse workers. Scand J Work Environ Health 2003; 29: 85–93.PubMedGoogle Scholar
  6. Tielemans E, Burdorf A, Velde ER te, et al. Occupationally related exposures and reduced semen quality: a case-control study. Fertil Steril 1999; 71: 690–696.CrossRefPubMedGoogle Scholar
  7. Tielemans E, Kooij R van, Looman C, et al. Paternal occupational exposures and implantation rates after IVF. Fertil Steril 2000; 74: 690–695.CrossRefPubMedGoogle Scholar
  8. Kristensen P, Andersen A, Irgens LM, et al. Cancer in offspring of parents engaged in agricultural activities in Norway: incidence and risk factors in the farm environment. Int J Cancer 1996; 65: 39–50.CrossRefPubMedGoogle Scholar
  9. Borja-Aburto VH, Herz-Picciotto I, Rojas Lopes MR, et al. Blood lead levels measured prospectively and risk of spontaneous abortion. Am J Epidemiol 1999; 150: 590–597.PubMedGoogle Scholar
  10. Rachootin P, Olsen J. The risk of infertility and delayed conception associated with exposures in the Danish workplace. J Occup Med 1983; 25: 394–402.PubMedGoogle Scholar
  11. Apostoli P, Kiss P, Porru S, Bonde JP, Vanhoorne M, and the ASCLEPIOS study group. Male reproductive toxicity of lead in animals and humans. Occup Environ Med 1998; 55: 364–374.CrossRefPubMedGoogle Scholar
  12. Savitz DA, Sonnenfeld NL, Olshan AF. Review of epidemiologic studies of paternal occupational exposure and spontaneous abortion. Am J Ind Med 1994; 25: 361–383.CrossRefPubMedGoogle Scholar
  13. Sallmén M. Fertility among workers exposed to solvents or lead [Academic dissertation]. People and Work, Research Reports 37. Helsinki: Finnish Institute of Occupational Health, 2000.Google Scholar
  14. Olshan AF, Faustman EM. Male-mediated developmental toxicity. Ann Rev Publ Health 1993; 14: 159–181.CrossRefGoogle Scholar
  15. Benoff S, Hurley IR, Millan C, et al. Seminal lead concentration negatively affect outcomes of artificial insemination. Fertil Steril 2003; 80: 517–525.CrossRefPubMedGoogle Scholar
  16. Gandley R, Anderson L, Silbergeld EK. Lead: Malemediated effects on reproduction and development in the rat. Environ Res 1999; 80: 355–363.CrossRefPubMedGoogle Scholar
  17. Lindbohm M-L, Taskinen H. Reproductive hazards in the workplace. In: Goldman MB and Hatch MC (eds.), Women and Health. San Diego: Academic Press, 2000, pp. 463–473.CrossRefGoogle Scholar
  18. Luderer U, Bushley A, Stover BD, et al. Effects of occupational solvent exposure on reproductive hormone concentrations and fecundability in men. Am J Ind Med 2004; 46: 614–626.CrossRefPubMedGoogle Scholar
  19. Reutman SR, Lemasters GK, Knecht EA, et al. Evidence of reproductive endocrine effects in women with occupational fuel and solvent exposures. Environ Health Perspect 2002; 110: 805–811.PubMedGoogle Scholar
  20. Lindbohm M-L. Effects of parental exposure to solvents on pregnancy outcome. J Occup Environ Med 1995; 37: 908–914.CrossRefPubMedGoogle Scholar
  21. Sallmén M, Lindbohm M-L, Kyyrönen P, et al. Reduced fertility among women exposed to organic solvents. Am J Ind Med 1995; 27: 699–713.CrossRefPubMedGoogle Scholar
  22. Sallmén M, Lindbohm M-L, Anttila A, et al. Time to pregnancy among the wives of men exposed to organic solvents. Occup Environ Med 1998; 55: 24–30.CrossRefPubMedGoogle Scholar
  23. Logman JFS, Vries LE de, Hemels MEH, et al. Paternal solvent exposure and adverse pregnancy outcomes: A meta-analysis. Am J Ind Med 2005; 47: 37–44.CrossRefPubMedGoogle Scholar
  24. Plenge-Bönig A, Karmaus W. Exposure to toluene in the printing industry is associated with subfecundity in women but not in men. Occup Environ Med 1999; 56: 443–448.CrossRefPubMedGoogle Scholar
  25. Correa A, Gray RH, Cohen R, et al. Ethylene glycol ethers and risks of spontaneous abortion and subfertility. Am J Epidemiol 1996; 143: 707–717.PubMedGoogle Scholar
  26. Tas S, Lauwerys R, Lison D. Occupational hazards for the male reproductive system. Crit Rev Toxicol 1996; 26: 261–307.CrossRefPubMedGoogle Scholar

Copyright information

© Bohn Stafleu van Loghum 2006

Authors and Affiliations

  1. 1.

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