Skip to main content
SpringerLink
Log in

Nieuwe ontwikkelingen in de behandeling van het kortedarmsyndroom bij kinderen

Dieet en hormoontherapie

  • Artikelen
  • Published:
Tijdschrift voor kindergeneeskunde

Summary

Short bowel syndrome is characterized by malabsorption of nutrients, vitamins en trace elements, resulting in growth retardation. Children with short bowel syndrome are often dependent on total parenteral nutrion (tpn). Parenteral nutrition can have major adverse effects, such as venous access problems, central venous line infections and tpn-related liver damage. Treatment is focused on rehabilitation of the intestinal function and optimal enteral feeding. Research is directed towards optimization of dietary measures and trophic hormones to stimulate intestinal adaptation.

Samenvatting

Het kortedarmsyndroom wordt veroorzaakt door malabsorptie van macronutriënten, vitaminen en spoorelementen en gaat gepaard met gewichtsverlies. Kinderen met deze aandoening zijn vaak afhankelijk van parenterale voeding, hetgeen weer risico geeft op levensbedreigende complicaties. Aanpassingen in het dieet, maar ook hormoontherapie gericht op de adaptatie van het epitheel, zouden de opnamecapaciteit van de darm kunnen verbeteren, en daarmee afhankelijkheid van parenterale voeding kunnen voorkomen.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

literatuur

  • Messing B, Pigot F, Rongier M, et al. Intestinal absorption of free oral hyperalimentation in the very short bowel syndrome. Gastroenterology 1991;100:1502-8.

    CAS  PubMed  Google Scholar 

  • Jeppeson PB, Mortensen PW. Experimental approaches: dietary and hormone therapy. Best Pract Res Clin Gastroenterol 2003;17:1041-54.

    Article  CAS  Google Scholar 

  • Norgard DI, Hansen BS, Mortensen PB. Importance of colonic support for energy absorption as small bowel failure proceeds. Am J Clin Nutr 1996;64:222-31.

    Google Scholar 

  • Jeppesen PB, Mortensen PB. The influence of a preserved colon on the absorption of medium chain fat in patients with small bowel resection. Gut 1998;43:478-83.

    Article  CAS  PubMed  Google Scholar 

  • Bohane TD, Haka-Ikse K, Biggar WD, et al. A clinical study of young infants after small intestinal resection. J Pediatr 1979;94:552-8.

    Article  CAS  PubMed  Google Scholar 

  • Briet F, Flourié B, Achour L, et al. Bacterial adaptation in patients with short bowel and colon in continuity. Gastroenterology 1995;109:1446-53.

    Article  CAS  PubMed  Google Scholar 

  • Marteau P, Messing B, Arrigoni E, et al. Do patients with short-bowel syndrome need a lactose-free diet? Nutrition 1997;13:13-6.

    Article  CAS  PubMed  Google Scholar 

  • Lifschitz CH. Growth hormone for short bowel adaptation: is less more effective than more? [editorial]. J Pediatr Gastroenterol Nutr 2004;38(1):111-2.

    Article  PubMed  Google Scholar 

  • Jeppesen PB, Sanuinetti EL, Buchman A, et al. Teduglutide (ALX-0600), a dipeptidyl peptidase IV resistant glucagon-like peptide 2 analogue, improves intestinal function in short bowel syndrome patients. Gut 2005;54(9):1224-31.

    Article  CAS  PubMed  Google Scholar 

  • Severijnen RSVM, Swieten ECAM van, Tolboom JJM, et al. Contribution of growth hormone treatment in children with a short small bowel [thesis]. Short small bowel in children. 2004.

  • Byrne TA, Wilmore DW, Iyer K, et al. Growth hormone, glutamine, and an optimal diet reduces parenteral nutrition in patients with short bowel syndrome: a prospective, randomized, placebo-controlled, double-blind clinical trial. Ann Surg 2005;242 (5):655-61.

    Article  PubMed  Google Scholar 

  • Lifschitz C, Dugan C, Langston C, et al. Growth hormone therapy in children with short bowel syndrome: a randomized placebo-controlled trial. Gastroenterology 2003;124:A64.

    Article  Google Scholar 

  • Nucci AM, Finegold DN, Yaworski JA, et al. Results of growth trophic therapy in children with short bowel syndrome. J Pediatr Surg 2004;39(3):335-9.

    Article  PubMed  Google Scholar 

  • Sigalet DL, Martin G, Meddings J, et al. GLP-2 levels in infants with intestinal dysfunction. Pediatr Res 2004;56(3):371-6.

    Article  CAS  PubMed  Google Scholar 

  • Weiming Z, Ning L, Jieshou L. Effect of recombinant human growth hormone and enteral nutrition on short bowel sundrome. JPEN J Parenter Enteral Nutr 2004;28(6):377-81.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. www.kindergeneeskunde.bsl.nl

    J. A. J. M. Taminiau, D. Tibboel & E. H. H. M. Rings

Authors
  1. J. A. J. M. Taminiau
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. D. Tibboel
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. E. H. H. M. Rings
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to J. A. J. M. Taminiau.

Additional information

Dr. J.A.J.M. Taminiau, kinderarts-gastro-enteroloog, afdeling Kindergeneeskunde, Emma Kinderziekenhuis/amc, Amsterdam. Prof.dr. D. Tibboel, afdeling Kinderheelkunde, Intensive Care Kinderchirurgische Groep, Erasmus mc-Sophia Kinderziekenhuis, Rotterdam. Dr. E.H.H.M. Rings,, kinderarts-gastro-enteroloog, afdeling Kindergeneeskunde, Kindergastro-enterologie, Beatrix Kinderkliniek, umcg, Groningen.

Correspondentieadres: Dr. E.H.H.M. Rings, afdeling Kindergeneeskunde, Kindergastro-enterologie, Beatrix Kinderkliniek, umcg, Postbus 30001, 9700 RB Groningen

Rights and permissions

Reprints and permissions

About this article

Cite this article

Taminiau, J.A.J.M., Tibboel, D. & Rings, E.H.H.M. Nieuwe ontwikkelingen in de behandeling van het kortedarmsyndroom bij kinderen. KIND 74, 188–190 (2006). https://doi.org/10.1007/BF03061629

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF03061629

Search

Navigation