Riassunto
Allo scopo di accertare nel morbo di Hodgkin la compromissione di organi e/o tessuti diversi dalle linfoghiandole, sono state impiegate 4 tecniche radioisotopiche: scintigrafia del fegato (32 casi), scintigrafia della milza (29 casi), scintigrafia ossea (30 casi) ed il test di sequestrazione splenica di globuli rossi marcati con51Cr e denaturati al calore (23 casi). Sono riportati i risultati di tali indagini. In particolare viene sottolineata l’utilità della scintigrafia ossea e, in minor misura, delle indagini morfologiche e funzionali della milza.
Summary
In order to investigate whether organs and/or tissues other than lymphnodes are impaired in Hodgkin’s disease, 4 radioisotopic techniques are proposed: scintigraphic scanning of the liver was employed in 32 cases, of the spleen in 29 cases, bone scanning in 30 cases, and splenic trapping of heat-damaged51Cr-labelled erythrocytes in 23 cases. The results are reported. Bone scanning and to a lesser extent morphological and functional investigations of the spleen are stated to be useful.
This is a preview of subscription content, log in via an institution to check access.
References
Ascari E.: L’impiego delle metodiche scintigrafiche nella classificazione del morbo di Hodgkin - Haematologica55, 525, 1970.
Badrawi H. S., Razzak M. A., Guirgis B.: Splenic Trapping of Heated-Erythrocytes in Leukemia and Allied Conditions — In: Symp. Dynamic Studies Radioisotopes Clin. Med. and Research. Rotterdam, 31 August-4 September 1970.I.A.E.A.
Cajozzo A., Citarrella P., Carreca I., Indovina I.: La fotoscintigrafia splenica con camera a scintillazione nello studio dell’attività sequestrante ed emocateretica della milza - Haematologica55, 373, 1970.
Cantor R. E., Cohon E. M., Park C. H., Shapiro B.: Comparative Liver Scanning: Technetium Sulfide-99mTc versus Gold-198Au - J. Amer. med. Ass.211, 1677, 1970.
Clementi T., Spina G.: La scintigrafia epatica nel morbo di Hodgkin - Nunt. radiol. (Roma)33, 1049, 1967.
Cohen M. B.: Cirrhosis and the Hepatic Photoscan - Radiology93, 1139, 1969.
Fischer J., Wolf R.: Das Funktions-Bild der sequestratorischen Leistung des retikulohistiozytären Systems - Helv. med. Acta31, 579, 1964.
Fischer J., Wolf R.: Nuclear Medicine in Hematology — Hoechst, English edition, 1968; p. 34.
Fischer J., Wolf R., Mundscher H., Leon A., Hromec A.: The Clinical Value of the Function Investigation of the Spleen Using51Cr-Labelled, Heat-Damaged Erythrocytes — In: Symp. Dynamic Studies Radioisotopes Clin. Med. and Research. Rotterdam, 31 August-4 September 1970. I.A.E.A.
Freeman L. M., Johnson P. N.: Clinical Scintillation Scanning - Harper and Row Publ., New York-Evaston-London, 1969; p. 269.
Harbert J. C, Ashburn W. L.: Radiostrontium Bone Scanning in Hodgkin’s Disease - Cancer22, 58, 1968.
Juillard G., Pierotti T., Abbes M., Kermarec J.: Intérêt de la scintigraphie splénique dans la maladie de Hodgkin. À propos de vingt cas - Presse méd.77, 1241, 1969.
Lipton M. J., DeNardo G. L., Silverman S., Glatstein E.: Evaluation of the Liver and Spleen in Hodgkin’s Disease. I. The Value of Hepatic Scintigraphy - Amer. J. Med.52, 356, 1972.
McCready V. R., Gwyther M. M., Stringer A. M.: Scintigraphy in the Diagnosis and Treatment of Malignant Lymphomas — Symposium on Medical Radioisotope Scintigraphy. I.A.E.A. Salzburg, Austria, 6-12 August, 1968.
Molander D. W., Ariel I. M., Pack G. T.: Hepatic Gammascanning as an Aid in the Manage- ment of Patients with Malignant Lymphomas - Amer. J. Roentgenol.99, 851, 1967.
Parmentier C, Askienazy S., Gerard-Marchant R., Lacour J., Amiel J. L., Lemerle J., Tubiana M.: Confrontations entre les données de la scintigraphie splénique et les constatations dans la maladie de Hodgkin - Ann. Radiol.12, 43, 1969.
Parmentier C, Di Paola R., Bazin J. P., Gerard-Marchant R., Gardet P., Fragu P., Chauvel P.: Apport de la scintigraphie numérique dans l’interpretation des scintigraphies spléniques. À propos de 50 confrontations anatomo-scintigraphiques chez des sujets atteints d’hématosarcome — Symposium on Medical Radioisotope Scintigraphy. Monte Carlo, 23-28 October 1972. I.A.E.A.
Pettit J. E., Williams E. D., Glass H. I., Lewis S. M., Szur L., Wicks G. I.: Studies of Splenic Function in the Myeloproliferative Disorders and Generalized Malignant Lymphomas - Brit. J. Hemat.20, 515, 1971.
Rosenberg S. A. (Chairman),Boiron M., De Vita V. T., Johnson J. R. E., Burton J. L., Ultmann J. E., Viamonte M. Jr.: Report of the Committee on Hodgkin’s Disease Staging Procedures - Cancer Res.31, 1892, 1971.
Sheagren J. N., Block J. B., Wolff S. M.: Reticuloendothelial System Phagocytic Function in Patients with Hodgkin’s Disease - J. clin. Invest.40, 855, 1967.
Silingardi V., Canossi G. C, De Maria D., Ascari E., Curci G.: Prime esperienze sulla scintigrafia epatica nel morbo di Hodgkin - Haematologica55, 727, 1970.
Silverman S., DeNardo G. L., Glatstein E., Lipton M. J.: Evaluation of the Liver and Spleen in Hodgkin’s Disease. II. The Value of Splenic Scintigraphy - Amer. J. Med.52, 362, 1972.
Spinelli Ressi F., Cattaneo N., Banfi F.: The Sequestration of Red Cells Labelled with B.M.H.P.-197Hg as a Test of Splenic Function - J. nucl. Biol. Med.11, 9, 1967.
Vangelista R., Ravasini R., Salerno C, Ongaro M.: Possibilità e limiti della semeiotica scintigrafica nella patologia epatica - Quad. Radiol.33, 711, 1968.
Viala J. J., Dechavanne M., Barbier Y.: La scintigraphie hépatique et splénique dans la maladie de Hodgkin. Acquisitions récentes en Hématologie - Simep éditions, Villeurbanne, France, 1971; p. 169.
Wilson F. E., Preston D. F., Overholt E. L.: Detection of Hepatic Neoplasm (Hepatic Scanning Combined with Liver Function Studies) - J. Amer. med. Ass.209, 676, 1969.
Ziliotto D.: Scintigrafia clinica - Cedam, Padova, 1971.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Dri, A.V., Barbui, T., Chisesi, T. et al. Indagini radioisotopiche nello studio del morbo di hodgkin. La Ricerca Clin. Lab. 4, 229–248 (1974). https://doi.org/10.1007/BF03055052
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF03055052