Advertisement

La Ricerca in Clinica e in Laboratorio

, Volume 2, Issue 1–4, pp 439–449 | Cite as

Attività fibrinolitica indotta dalla stasi venosa prima e dopo il parto

  • Jacqueline Conard
  • Nicola Ciavarella
  • Meyer Samama
Original Contribution
  • 27 Downloads

Riassunto

L’attività fibrinolitica provocata dalla s.v. è stata studiata in soggetti di sesso femminile di età ben comparabile: 10 donne normali, 10 donne normali e 8 diabetiche durante il terzo trimestre di gravidanza, 11 donne nel post-partum e 10 donne trattate con anticoncezionali a basso dosaggio di estrogeni. Tutte hanno risposto alla s.v. con un forte incremento dell’A.F., eccetto il gruppo délie donne gravide. Questa abnorme risposta può essere il risultato di una inibizione esercitata dalla placenta. Poiché la trombosi non sembra essere più fréquente in gravidanza, altri fattori possono essere importanti nel determinismo di essa.

Fibrinolytic activity induced by venous stasis before and after childbirth

Summary

The fibrinolytic activity induced by v.s. has been studied in women: 10 normal, 10 normal and 8 diabetic women in their last trimester of pregnancy, 11 in the post-partum period, and 10 under oral contraception with low oestrogen content. All of them responded to the v.s. by a marked increase of the F.A., except the group of pregnant women. This abnormal response may be the result of an inhibition exerted by placenta. As thrombosis does not seem to be more frequent in pregnancy, some other factors may be more important to trigger the mechanism.

Key-words

Fibrinolysis Oral contraception Post-partum Pregnancy 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1).
    Astedt B., Isacson S., Nilsson I. M., Pandolfi M.: Fibrinolytic Activity of Veins during Pregnancy — Acta obstet, gynec. scand.49, 171, 1970.CrossRefGoogle Scholar
  2. 2).
    Bonnar J., McNicol G. P., Douglas A. S.: Coagulation and Fibrinolytic Mechanism during and after Childbirth — Brit. med. J.2, 200, 1970,PubMedCrossRefGoogle Scholar
  3. 3).
    Ciavarella N., Conard J., Samama M.: Fibrinolytic Activity in Venous Stasis — Brit. med. J.3, 466, 1970.CrossRefGoogle Scholar
  4. 4).
    Ciavarella N., Conard J., Samama M.: Effect of Venous Occlusion on Fibrinolysis before and after Delivery. Problems Related to Fibrinolysis — J. clin. Path.25, 619, 1972.PubMedCrossRefGoogle Scholar
  5. 5).
    Clarke R. L., Orandi A., Cliffton E. E.: Induction of Fibrinolysis by Venous Obstruction — Angiology11, 367, 1960.PubMedCrossRefGoogle Scholar
  6. 6).
    Fearnley G. R., Balmforth G., Fearnley E.: Evidence of a Diurnal Fibrinolytic Rhythm with a Simple Method of Measuring Natural Fibrinolysis — Clin. Sci.16, 645, 1957.PubMedGoogle Scholar
  7. 7).
    Holemans R.: Increase in Fibrinolytic Activity by Venous Occlusion — J. appl. Physiol.18, 1123, 1963.PubMedGoogle Scholar
  8. 8).
    Nilsson I. M.: Changes in the Coagulation and Fibrinolytic Systems Predisposing to Thrombosis — Acta chir. scand.387, 15, 1968.Google Scholar
  9. 9).
    Nilsson I. M., Robertson B.: Effect of Venous Occlusion on Coagulation and Fibrinolytic Components in Normal Subjects — Thrombos. Diathes. haemorrh. (Stuttg.)20, 397, 1968.Google Scholar
  10. 10).
    Pandolfi M., Nilsson I. M., Robertson B., Isacson S.: Fibrinolytic Activity of Human Veins — Lancet2, 127, 1967.PubMedCrossRefGoogle Scholar
  11. 11).
    Todd A. S.: The Histological Localisation of Fibrinolysin Activator — J. Path. Bact.78, 281, 1959.PubMedCrossRefGoogle Scholar
  12. 12).
    Uszynski M., Abilgaard V.: Purification and Properties of Two Fibrinolytic Inhibitors from Human Placenta — In: XIII Internat. Congr. Hemat., Munich. Addendum. Abstract, 1970.Google Scholar
  13. 13).
    vonKaulla K. N., Schultz R. L.: Methods for the Evaluation of Human Fibrinolysis. Studies with Two Combined Techniques — Amer. J. clin. Path.29, 104, 1958.Google Scholar

Copyright information

© Springer-Verlag 1972

Authors and Affiliations

  • Jacqueline Conard
    • 2
  • Nicola Ciavarella
    • 1
  • Meyer Samama
    • 2
  1. 1.BariItalia
  2. 2.Laboratoire central d’hématologie de l’hÔtel-dieu Paris istituto di clinica medica ii dell’università degli studi di BariItalia

Personalised recommendations