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La Ricerca in Clinica e in Laboratorio

, Volume 2, Issue 1–4, pp 83–148 | Cite as

Diagnosi morfologica e funzionale mediante l’impiego di una camera a scintillazone e di un sistema per l’elaborazione dei dati

  • Günter Golde
  • Sebastian Lange
  • Karl zum Winkel
  • Friedrich Motzkus
  • Lena Schmidt
  • Heidemarie Jost
  • Birendra K. Das
Article
  • 11 Downloads

Riassunto

La scinticamera associata con il sistema cinescintigrafico, che è compatibile con il computer, permette numerose applicazioni in campo diagnostico morfologico e funzionale. Usando questo sistema combinato abbiamo eseguito studi sulla circolazione del sangue e misurato il tempo di transito della circolazione cardiaca e vascolare. È stata anche indagata la cinetica del Pertecnetato nella tiroide, ricavandone un metodo utile per loscreening della funzione tiroidea. La funzione del rene è stata studiata in oltre 1.000 casi, costruendo curve ehe rappresentano la cinetica delle sostanze radioattive sia nell’organoin toto che in aree circoscritte di esso. Con l’aiuto del computer abbiamo calcolato differenti parametri. Le nostre conoscenze sul comportamento funzionale di certi organi risultano approfondite se si studia l’alterata cinetica dei traccianti sotto l’azione di farmaci. I risultati ottenuti da oltre 100 esami sulle ghiandole salivari hanno dimostrato che il Pertecnetato in esse raccoltosi viene quasi completamente rilasciato dopo 1’applicazione di Doryl®. La concentrazione di Pertecnetato nella mucosa gastrica è apparsa aumentare considerevolmente quando abbiamo stimolato la secrezione gastrica con Betazolo o Pentagastrina. Abbiamo studiato la cinetica del Rosa bengala nel fegato, nella cistifellea, nel sangue e nell’intestino; in oltre 30 pazienti si è osservato il comportamento della curva di radioattività sotto l’azione di un pasto stimolante.

Functional and morphological diagnosis using the scintillation camera and a data processing system

Summary

The scintillation combined with the cinescintigraphic system, which is computer compatible, permits numerous applications in functional and morphological diagnosis. Using this combined system blood flow studies were carried out showing the transit time of cardiac and vascular circulation. The kinetics of Pertechnetate in the thyroid was investigated and an useful method for screening thyroid function was developed. In more than 1,000 cases renal function studies were performed by drawing curves representing the kinetics of radiopharmaceutical in the whole organ as well as in circumscribed regions. With the aid of the computer different parameters were calculated. Functional studies of certain organs are improved by examining the altered kinetics of radiopharmaceuticals under the influence of drugs. Results of more than 100 examinations of salivary glands revealed that the accumulate Pertechnetate was almost completely discharged after application of Doryl®. The concentration of Pertechnetate in the gastric mucosa was considerably increased by administering Betazol and Pentagastrine, corresponding to a stimulation of gastric secretion. The kinetics of Rose bengal in the liver, the gall bladder, the blood and the intestinal tract were examined. In more than 30 patients the slope of the radioactivity was observed under the influence of a stimulating diet.

Key-words

Data processing Functional studies Heart Kidney Liver Salivary gland Scintillation camera Stomach Thyroid gland 

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Copyright information

© Springer-Verlag 1972

Authors and Affiliations

  • Günter Golde
    • 1
  • Sebastian Lange
    • 1
  • Karl zum Winkel
    • 1
  • Friedrich Motzkus
    • 1
  • Lena Schmidt
    • 1
  • Heidemarie Jost
    • 1
  • Birendra K. Das
    • 1
  1. 1.Universitaets- Strahleninstitut im Klinikum WestendDl Berlin 19Berlin

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