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Functional and morphological diagnosis using the scintillation camera and a data processing system

Diagnosi morfologica e funzionale mediante l’impiego di una camera a scintillazone e di un sistema per l’elaborazione dei dati

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La Ricerca in Clinica e in Laboratorio

Riassunto

La scinticamera associata con il sistema cinescintigrafico, che è compatibile con il computer, permette numerose applicazioni in campo diagnostico morfologico e funzionale. Usando questo sistema combinato abbiamo eseguito studi sulla circolazione del sangue e misurato il tempo di transito della circolazione cardiaca e vascolare. È stata anche indagata la cinetica del Pertecnetato nella tiroide, ricavandone un metodo utile per loscreening della funzione tiroidea. La funzione del rene è stata studiata in oltre 1.000 casi, costruendo curve ehe rappresentano la cinetica delle sostanze radioattive sia nell’organoin toto che in aree circoscritte di esso. Con l’aiuto del computer abbiamo calcolato differenti parametri. Le nostre conoscenze sul comportamento funzionale di certi organi risultano approfondite se si studia l’alterata cinetica dei traccianti sotto l’azione di farmaci. I risultati ottenuti da oltre 100 esami sulle ghiandole salivari hanno dimostrato che il Pertecnetato in esse raccoltosi viene quasi completamente rilasciato dopo 1’applicazione di Doryl®. La concentrazione di Pertecnetato nella mucosa gastrica è apparsa aumentare considerevolmente quando abbiamo stimolato la secrezione gastrica con Betazolo o Pentagastrina. Abbiamo studiato la cinetica del Rosa bengala nel fegato, nella cistifellea, nel sangue e nell’intestino; in oltre 30 pazienti si è osservato il comportamento della curva di radioattività sotto l’azione di un pasto stimolante.

Summary

The scintillation combined with the cinescintigraphic system, which is computer compatible, permits numerous applications in functional and morphological diagnosis. Using this combined system blood flow studies were carried out showing the transit time of cardiac and vascular circulation. The kinetics of Pertechnetate in the thyroid was investigated and an useful method for screening thyroid function was developed. In more than 1,000 cases renal function studies were performed by drawing curves representing the kinetics of radiopharmaceutical in the whole organ as well as in circumscribed regions. With the aid of the computer different parameters were calculated. Functional studies of certain organs are improved by examining the altered kinetics of radiopharmaceuticals under the influence of drugs. Results of more than 100 examinations of salivary glands revealed that the accumulate Pertechnetate was almost completely discharged after application of Doryl®. The concentration of Pertechnetate in the gastric mucosa was considerably increased by administering Betazol and Pentagastrine, corresponding to a stimulation of gastric secretion. The kinetics of Rose bengal in the liver, the gall bladder, the blood and the intestinal tract were examined. In more than 30 patients the slope of the radioactivity was observed under the influence of a stimulating diet.

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References

  1. Andros G., Harper P.: Pertechnetate-99m Localization in Man with Application to Thyroid Scanning and the Study of Thyroid Physiology — J. clin. Endocr.25, 1067, 1965.

    Article  PubMed  CAS  Google Scholar 

  2. Anger H. O.: Scintillation Camera — Rev. Scient. Instrum.29, 27, 1958.

    Article  CAS  Google Scholar 

  3. Anger H. O., Powell M. R., vanDyke D. K., Schaer L. R., Fawwaz R., Yano Y.: Recent Application of the Scintillation Camera — In: Radioaktive Isotope in Klinik und Forschung, Vol. 7. Urban und Schwarzenberg, München 1967.

    Google Scholar 

  4. Atkins W. L.: Assessment of Thyroid Function and Anatomy with99mTc as Pertechnetate - J. nucl. Med.9, 7, 1968.

    PubMed  CAS  Google Scholar 

  5. Bender M., Blau M.: Evaluation of Renal and Cardiac Dynamics with the Autofluoroscope - J. nucl. Med.4, 186, 1963.

    Google Scholar 

  6. Bender M. A., Moussa-Mahmond L., Blau M.: Quantitative Radiocardiography with the Digital Autofluoroscope — Symp. Med. Radioisotope Scintigraphy, Int. Atomic Energy Agency, Salzburg 1968.

    Google Scholar 

  7. Bequevort P.: Contribution à l’étude du99mTc-Pertéchnetate comme traceur dans les affections thyroïdiennes — Dissertation, license en Sciences Nucléaires, Université de Liège, 1968.

  8. Börner W., Grünberg H., Moll E.: Szintigraphische Darstellung der Kopfspeicheldrüsen mit Technetium99m — Med. Welt (Berl.)42, 2378, 1965.

    Google Scholar 

  9. Burke G., Halko A.: Dynamic Clinical Studies with Radioisotopes and Scintillation Camera. II. Rose Bengal131I Liver Function Studies — J. Amer. med. Ass.198, 608, 1966.

    Article  CAS  Google Scholar 

  10. Eyler W. R., Schumann B. M., duSault L. A., Hinson R. E.: Radioiodinated Rose Bengal Liver Scan as Aid in Differential Diagnosis of Jaundice — Amer. J. Roentgenol.94, 469, 1965.

    Google Scholar 

  11. Feine U., zum Winkel K.: Nuklearmedizin-Szintigraphische Diagnostik — Georg Thieme- Verlag, Stuttgart 1969.

  12. Friedrich R., Engelhart G.: Der Wert der Magenszintigraphie mit Technetium-99m als diagnostisches Routineverfahren — Schweiz. med. Wschr.98, 1789, 1968.

    Google Scholar 

  13. Gelinsky P., zumWinkel K., Hasper M.: Szintigraphische Dokumentation des Sjögren Syndrom — Fortschr. Röntgenstr.110, 266, 1969.

    CAS  Google Scholar 

  14. Grünberg H., Borner W.:99mTc-Pertechnetate-Szintigraphie in der Diagnostik von Krankheiten der Kopfspeicheldrüsen — Arch. klin. exp. Ohr.-, Nas.-, u. Kehlk.-Heilk.187, 714, 1966.

    Article  Google Scholar 

  15. Harden R., Alexander W. D., Kennedy J.: Isotope Uptake and Scanning of Stomach in Man with99mTc-Pertechnetate — Lancet1, 1305, 1967.

    Article  PubMed  CAS  Google Scholar 

  16. Harper P. V., Lathrop K., Jimenez F., Fink R., Gottschalk A.: Technetium-99m as a Scanning Agent — Radiology85, 101, 1965.

    PubMed  CAS  Google Scholar 

  17. Harper P. V., Lathrop K. A., Hinn G. M., Andros G.: Pertechnetate — In: Radioactive Pharmaceuticals. U.S. Atomic Energy Commission, Oak Ridge 1966.

    Google Scholar 

  18. Haubold U., Jost H., zumWinkel K.: Sequenzszintigraphien der Niere mit131J-o-Jodhippu- säure und113mIn-EDTA — Strahlentherapie140, 89, 1970.

    PubMed  CAS  Google Scholar 

  19. Iio M., Yamada H., Kameda H., Ueda H., Iuchi M., Ishida M.: Diagnosis and Differentiation of Constitutional Hyperbilirubinemias Using Sequential Scanning with131I-BSP (Monoiodide) - J. nucl. Med.12, 95, 1971.

    PubMed  CAS  Google Scholar 

  20. Irvine W., Stewart A., McLonghlin G., Tothill P.: Appraisal of the Application of99mTc in the Assessment of Gastric Function — Lancet2, 648, 1967.

    Article  PubMed  CAS  Google Scholar 

  21. Kessler L., Otto H. J.: Zum diagnostischen Wert der Kameraszintigraphie bei Funktionsstörungen der Kopfspeicheldrüsen — Z. Laryng. Rhinol.43, 495, 1969.

    Google Scholar 

  22. Kuba J., Knoll P.: Technetium-99m in der Diagnostik von Schilddrüsenerkrankungen - Fortschr. Röntgenstr.105, 84, 1966.

    Google Scholar 

  23. Lindenbraten L. D., Judin L. A.: Komplexe Untersuchung der Speicheldrüsen mittels radioaktiven Isotopen und Röntgenstrahlen — Fortschr. Röntgenstr.108, 23, 1968.

    CAS  Google Scholar 

  24. Müller-Beissenhirtz P., Ziegler M., zumWinkel K., Beduhn D., Encke A., Pöplan F., Ruland S.: Die Sequenzszintigraphie und die Angiographie zur Diagnostik der Abstoss-ungskrisen von experimentellen Nierentransplantaten — Fortschr. Röntgenstr.113, 148, 1970.

    Google Scholar 

  25. Nagel R., zum Winkel K., Neide E. L., Jost H., Sonderkamp H. M., Frisius H., Marx F.: The Diagnosis of Renal Lesions by Serial Scintigraphy and Angiography — Intern. Sympos. Radionuclides in Nephrology, New York, January 1971.

  26. Powell M. R., Anger H. O.: Blood Flow Visualization with the Scintillation Camera — J. nucl. Med.7, 729, 1966.

    PubMed  CAS  Google Scholar 

  27. Rosenthall L.: Radionuclide Diagnosis of Malignant Tumors of the Kidney — Amer. J. Roentgenol.101, 662, 1967.

    PubMed  CAS  Google Scholar 

  28. Schenk P., zum Winkel K., Maier Borst W., Szegvary M.: Angiocardiographie mit der Szintillations-Kamera — 5. Jahrestagg. Ges. Nuclearmed. Wien 1967.

  29. Schmidt L.: Ergänzender Beitrag zum Tagungsbericht der Oto-Laryngol — H.N.O. (Berl.)19, 287, 1971.

    Google Scholar 

  30. Schmidt L.: Die Untersuchung der Speicheldrüsenfunktion durch Serienszintigraphie — 52. Tag. Dtsch. Ges. Röntgenologie, Düsseldorf 1971.

  31. Taplin G. V., Meredith O. M. Jr.,Kade H.: Radioactive I131-Tagged Rose Bengal Uptake Excretion Test for Liver Function Counting Techniques — J. Lab. clin. Med.45, 665, 1955.

    PubMed  CAS  Google Scholar 

  32. Tothill P., Irvine W.: The Use of Technetium-99m for Thyroid Scanning and Thyroid Function Testing — In: Radioaktive Isotope in Klinik und Forschung, Vol. 7, 29 — Urban und Schwarzenberg, München.

  33. Yamada H., Swanson L. A., Johnson D. E., Taplin G. V.: Sequential Liver and Upper Abdominal Scanning in Hepatobiliary Disease — J. nucl. Med.9, 361, 1968.

    Google Scholar 

  34. zum Winkel K.: Nierendiagnostik mit Radioisotopen — Georg Thieme, Stuttgart 1964.

  35. zumWinkel K., Hallwachs O., Steinhausen M.: Kameraszintigraphie und Isotopen-nephrographie an der Hundeniere und deren Überprüfung durch die Intravitalmikroskopie - Fortschr. Röntgenstr.108, 382, 1968.

    Article  Google Scholar 

  36. zumWinkel K., Harbst H., Schenk P., Franz H. E., Ritz E., Röhl L., Ziegler M., Ammann W., Maier Borst W.: Sequential Scintigraphy in Renal Transplantation. Medical Radioisotope Scintigraphy — I.A.E.A., Vienna 1969.

    Google Scholar 

  37. zumWinkel K., Jost H., Motzkus F., Golde G.: Renal Studies with Radioisotopes. Dynamic Studies with Radioisotopes in Medicine — I.A.E.A., Vienna 1971.

    Google Scholar 

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Authors and Affiliations

  1. Universitaets- Strahleninstitut im Klinikum Westend, Spandauer Damm 130, Dl Berlin 19, Berlin

    Günter Golde, Sebastian Lange, Karl zum Winkel, Friedrich Motzkus, Lena Schmidt, Heidemarie Jost & Birendra K. Das

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  1. Günter Golde
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  2. Sebastian Lange
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  3. Karl zum Winkel
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  4. Friedrich Motzkus
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  6. Heidemarie Jost
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  7. Birendra K. Das
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Golde, G., Lange, S., zum Winkel, K. et al. Functional and morphological diagnosis using the scintillation camera and a data processing system. La Ricerca Clin. Lab. 2, 83–148 (1972). https://doi.org/10.1007/BF03054755

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