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La Ricerca in Clinica e in Laboratorio

, Volume 1, Issue 1–4, pp 621–642 | Cite as

I tests di funzionalità tiroidea mediante radioisotopi

  • Thomas M. D. Gimlette
Nuclear Medicine Section
  • 15 Downloads

Riassunto

Si illustrano gli scopi ed i limiti delle prove di funzionalità tiroidea. Si discutono i rispettivi vantaggi e svantaggi di diverse provein vivo con impiego di radioisotopi dello iodio e con tecnezio, confrontandoli con i metodiin vitro, con particolare riguardo alla valutazione della condizione tiroidea. Si accenna anche ad alcune recenti tendenze di sviluppo delle prove di laboratorio riguardanti 1a tiroide e ad alcuni problemi particolari.

Thyroid function tests using radioisotopes

Summary

The aim and limitations of thyroid function tests are indicated. The relative advantages and disadvantages of various methods of testingin vivo with radioisotopes of iodine and with technetium are discussed and compared within vitro methods, with particular reference to the assessment of thyroid status. Some recent trends in the development of thyroid tests and some particular problems are mentioned.

Key-words

Diagnosis in vitro and in vivo Radioisotope Thyroid Thyroxine Triiodothyronine 

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References

  1. 1).
    Acland J. D.: The Interpretation of the Serum Protein-Bound Iodine: A Review - J. clin. Path.24, 187, 1971.PubMedCrossRefGoogle Scholar
  2. 2).
    Adams R., Specht N., Woodward I.: Labelling of Erythrocytes in Vitro with Radioiodine Tagged l-Triiodothyronine as an Index of Thyroid Function: an Improved Haematocrit Correction - J. clin. Endocr.20, 1366, 1960.PubMedCrossRefGoogle Scholar
  3. 3).
    Alexander W. D., McLarty D. G., Robertson J., Shimmins J., Brownlie B. W., Harden R. McG., Patel A. R.: Prediction of Long-Term Results of Antithyroid Drug Therapy for Thyrotoxicosis- J. clin. Endocr.30, 540, 1970.PubMedCrossRefGoogle Scholar
  4. 4).
    Alexander W. D., Shimmins J., Robertson J.W. K., Horton P. W., McLarty D. G., Harden R. McG.: Radioisotope Studies of Thyroid Function and Thyroid Hormone Metabolism - I.A.E.A. Symposium 136, I.A.E.A. Vienna, 1971.Google Scholar
  5. 5).
    Boddy K., Harden R. McG., Alexander W. D.: In Vivo Measurement of Intrathyroidal Iodine Concentration in Man by Activation Analysis - J. clin. Endocr.28, 294, 1968.PubMedCrossRefGoogle Scholar
  6. 6).
    Bowers C. Y., Schally A. V., Hawley W. D., Gual C., Parlow A.: Effect of Thyrotrophin-Releasing Factor in Man - J. clin. Endocr.28, 978, 1968.PubMedCrossRefGoogle Scholar
  7. 7).
    Branson B. M., Wellman H. N., Kereiakos J. G.: An Ultrasensitive123I Uptake System Utilizing Peak: Scatter Organ Depth Correction - Int. J. appl. Radiat.20, 502, 1971.CrossRefGoogle Scholar
  8. 8).
    Cavalieri R. R., Steinberg M., Searle G. L.: The Distribution Kinetics of Triiodothyronine: Studies of Euthyroid Subjects with Decreased Plasma Thyroxine-Binding Globulin and Patients with Graves’ Disease - J. clin. Invest.49, 1041, 1970.PubMedCrossRefGoogle Scholar
  9. 9).
    Clark F., Hall R.: Chlordiazepoxide (Librium) and Tests of Thyroid Function - Brit, med. J.2, 266, 1970.CrossRefGoogle Scholar
  10. 10).
    Clark F., Horn D. R.: Assessment of Thyroid Function by the Combined Use of the Serum Protein-Bound Iodine and Resin Uptake of131I Triiodothyronine - J. clin. Endocr.25, 39, 1965.PubMedCrossRefGoogle Scholar
  11. 11).
    Elzinga K. E., Carr E. A., Beierwaltes W. H.: Adaptation of the Standard Durrum-Type Cell for Reverse-Flow Paper Electrophoresis - Amer. J. clin. Path.36, 125, 1961.Google Scholar
  12. 12).
    Gimlette T. M. D.: Current Tests of Thyroid Function and their Correlation - In: Gardiner-Hill H. (Ed.): Modern Trends in Endocrinology. Butterworths, London, 1967.Google Scholar
  13. 13).
    Gimlette T. M. D., Clarke J. M.: A Comparison of in Vitro Methods and Others in the Assessment of Thyroid Status - I.A.E.A. Symposium 124, I.A.E.A. Vienna, 1970.Google Scholar
  14. 14).
    Gimlette T. M. D., Piffanelli A.: Assessment of Thyroid Status in Pregnant Women and in Patients Taking Oral Contraceptives by a Free Thyroxine Index - J. clin. Path.20, 767, 1968.CrossRefGoogle Scholar
  15. 15).
    Goolden A. W. G.: Use of Radioactive Iodine in the Diagnosis of Thyroid Disorders - Brit. med. Bull.16, 105, 1960.PubMedGoogle Scholar
  16. 16).
    Hall R., Amos J., Gary R., Buxton R. L.: Thyroid-Stimulating Hormone Response to Synthetic Thyrotrophin Releasing Hormone in Man - Brit. med. J.2, 274, 1970.PubMedCrossRefGoogle Scholar
  17. 17).
    Hall R., Amos J., Ormston B. J.: Thyroid-Stimulating Hormone Response to Synthetic Thyrotrophin Releasing Hormone in Man - Brit. med. J.1, 582, 1971.PubMedCrossRefGoogle Scholar
  18. 18).
    Hamolski M. W., Stein M., Freedberg A. S.: The Thyroid Hormone Plasma Protein Complex in Man. II. A New in Vitro Method for the Study of ‘Uptake’ of Labelled Hormone Components by Human Erythrocytes - J. din. Endocr.17, 33, 1957.CrossRefGoogle Scholar
  19. 19).
    Harvey R. F.: Indices of Thyroid Function in Thyrotoxicosis - Lancet2, 230, 1971.PubMedCrossRefGoogle Scholar
  20. 20).
    Hoffer P. B., Charleston D. B., Beck R. N., Gottschalk A.: Fluorescent Thyroid Scanning: a New Method of Imaging the Thyroid - Radiology90, 342, 1968.Google Scholar
  21. 21).
    Hoschl R., Gimlette T. M. D.: Diagnostic Value of 20 Minute99mmTc-Pertechnetate Thyroid Uptake -Nucl.-Med. (Stuttg.)10, 305, 1971.Google Scholar
  22. 22).
    I.A.E.A.: Consultants Meeting on the Calibration and Standardization of Thyroid Radioiodine Uptake Measurements - Int. J. appl. Radiat.13, 167, 1962.CrossRefGoogle Scholar
  23. 23).
    Munro D. S.: The Long-Acting Thyroid Stimulator - Brit. J. Hosp. Med.3, 42, 1970.Google Scholar
  24. 24).
    Murphy B. P.: The Determination of Thyroxine by Competitive Protein-Binding Analysis Employing an Anion-Exchange Resin and Thyroxine - J. Lab. clin. Med.66, 161, 1965.Google Scholar
  25. 25).
    Oppenheimer J. H.: Role of Plasma Proteins in the Binding, Distribution and Metabolism of the Thyroid Hormones - New Engl. J. Med.278, 1153, 1968.PubMedGoogle Scholar
  26. 26).
    Ormston B. J., Garry R., Cryer R. J., Besser G. M., Hall R.: Thyrotrophin-Releasing Hormone as a Thyroid Function Test - Lancet2, 10, 1971.PubMedCrossRefGoogle Scholar
  27. 27).
    Riviere R., Comar D., Kellersohn C, Orr J. S., Gillespie F. C., Lenihan J. M. A.: Estimation of Thyroid Iodine Content by the Occupancy Principle - Lancet1, 389, 1969.PubMedCrossRefGoogle Scholar
  28. 28).
    Stanbury J. B.: The Constitutional Factor in Thyroid Disease - Proc. roy. Soc. Med.53, 904, 1960.PubMedGoogle Scholar
  29. 29).
    Sterling K.: The Importance of Circulating Triiodothyronine - New Engl. J. Med.284, 271, 1971.PubMedCrossRefGoogle Scholar
  30. 30).
    Sterling K., Bellabarba D., Newman E. S., Brenner M. A.: Determination of Triiodothyronine Concentration in Human Serum - J. din. Invest.48, 1150, 1969.Google Scholar
  31. 31).
    Sterling K., Brenner M. A.: Free Thyroxine in Human Serum: Simplified Measurement with the Aid of Magnesium Precipitation - J. clin. Invest.45, 153, 1966.PubMedCrossRefGoogle Scholar
  32. 32).
    Tata J. R., Pochin E. E.: Thyroid Cancer - In:Pitt-Rivers R., Trotter W.R. (Eds): The Thyroid Gland. Butterworths, London, 1964.Google Scholar
  33. 33).
    Utiger R. D.: Radioimmunoassay of Human Serum Thyrotrophin - J. clin. Invest.44, 1277, 1965.PubMedCrossRefGoogle Scholar
  34. 34).
    Wayne E. J., Koutras D. A., Alexander W. D.: Clinical Aspects of Iodine Metabolism -Blackwell, Oxford, 1964.Google Scholar
  35. 35).
    Wellman H. N., Kereiakos J. G., Yeager T. B., Kardus G. J., Saenger E. L.: A Sensitive Technique for Measuring Thyroidal Uptake of Iodine-131 - J. nucl. Med.8, 86, 1967.PubMedGoogle Scholar
  36. 36).
    Williams E. J., Ekins R., Ellis S. M.: Thyroid Stimulation Test with Serum Thyroxine Concentration as Index of Thyroid Response - Brit. med. J.4, 336, 1969.PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag 1971

Authors and Affiliations

  • Thomas M. D. Gimlette
    • 1
  1. 1.The Liverpool ClinicLiverpool 7Great Britain

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