Some evidence against the chemical theory of neuromuscular transmission

  • Inderjit Singh
  • Shakuntala Sharma
  • O. P. Bhatnagar

Summary and Conclusions

1. Some frog’s stomach muscles and dog’s stomach muscle continuously release acetylcholine.

2. Stimulation of vagus nerve increases the release of acetylcholine.

3. After the nerve has fatigued, direct electrical stimulation releases acetylcholine; this direct stimulus is far more potent than nervous stimulation, showing that the release of acetylcholine can occur independently of nervous stimulation.

4. In dog’s stomach muscle, the release of acetylcholine continues undiminished after the nerves have fatigued. It occurs whether the nerves are further stimulated or not. This suggests that the acetylcholine released during nervous stimulation originates from the muscle. These experiments therefore throw doubt on the chemical theory of neuromuscular transmission.


Nervous Stimulation Vagus Nerve Neuromuscular Transmission Stomach Muscle Chemical Theory 
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Copyright information

© Indian Academy of Sciences 1959

Authors and Affiliations

  • Inderjit Singh
    • 1
  • Shakuntala Sharma
    • 1
  • O. P. Bhatnagar
    • 1
  1. 1.From the Department of PhysiologyMedical CollegeAgra

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