The metabolism of serine in biotin deficiency

  • G. B. Nadkarni
  • A. Sreenivasan


Synthesis of serine from ethanolamine by carbon dioxide fixation is demonstrated to take place in presence of rat liver enzymes. The system is biotin-dependent.

Serine deaminase activity but not that of serine decarboxylase is also reduced in biotin deficiency.


Serine Biotin Ethanolamine Carbon Dioxide Fixation Biotin Deficiency 
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  1. Abelson, P. H., Bolton, E. T. and Aldous, E.J. Biol. Chem., 1952a,198, 165.PubMedGoogle Scholar
  2. —————.. Ibid., 1952b,198, 173.PubMedGoogle Scholar
  3. Alexander, J. C., Beckner, W. and Elvehjem, C. A.J. Nutr., 1953,51, 319.PubMedGoogle Scholar
  4. Burke, D. and Winzler, R. J...Science, 1943,97, 59.Google Scholar
  5. David, J. W., Cheldelin, V. H., Christensen, B. E., and Wang, C. H.Biochim. Biophys. Acta, 1956,21, 101.CrossRefGoogle Scholar
  6. Delwiche, E. A...J. Bact., 1950,59, 439.PubMedGoogle Scholar
  7. Eakin, R. E., Snell, E. E. and Williams, R. J.J. Biol. Chem., 1941,140, 535.Google Scholar
  8. Feldott, G. and Lardy, H. A... Ibid., 1951,192, 447.PubMedGoogle Scholar
  9. Folcn, J. and Schneider, H. A... Ibid., 1941,137, 51.Google Scholar
  10. Giri, K. V. and Rao, N. A. N...J. Ind. Inst. Sci., 1952,34, 95.Google Scholar
  11. Gothoskar, S. S. and Sreenivasan, A.Ind. J. Med. Res., 1953,41, 69.Google Scholar
  12. Hanke, M. E. and Siddiqui, M. S. H.Fed. Proc., 1950,9, 181.Google Scholar
  13. Koppleman, R., Mandeles, S. and Hanke, M. E. Ibid., 1952,11, 242.Google Scholar
  14. Lardy, H. A. and Adler, J...J. Biol. Chem., 1956,219, 933.PubMedGoogle Scholar
  15. —— McLeod, P. R., Grisolia, S. and Cohen, P. P. Ibid., 1949a,180, 1003.Google Scholar
  16. ——, Potter, R. L. and Burris, R. H. Ibid., 1949b,179, 721.PubMedGoogle Scholar
  17. ——, —— and Elvehjem, C. A. Ibid., 1947,169, 451.Google Scholar
  18. Levine, C. and Chargraff, E... Ibid., 1951,192, 465.PubMedGoogle Scholar
  19. Lichstein, H. C... Ibid., 1955,212, 217.PubMedGoogle Scholar
  20. —— and Christman, J. F... Ibid., 1948,175, 649.PubMedGoogle Scholar
  21. —— and Umbreit, W. W... Ibid., 1947,170, 423.Google Scholar
  22. McCoy, R. H., McKibben, J. N., Axelrod, A. E. and Hofmann, K. Ibid., 1948,176, 1319.PubMedGoogle Scholar
  23. McLeod, P. R. and Lardy, H. A... Ibid., 1949,179, 733.Google Scholar
  24. Nadkarni, G. B. and Sreenivasan, A.Proc. Ind. Acad. Sci., 1957,46 B, 138.Google Scholar
  25. Ochoa, S., Mehler, A., Blanchard, M. L., Jukes, T. H. and Hoffmann, C. E.J. Biol. Chem., 1947,170, 413.Google Scholar
  26. Plaut, G. W. E. and Lardy, H. A... Ibid., 1950,186, 705.PubMedGoogle Scholar
  27. Pilgeram, L. O., Gal, E. M., Sassenrath, E. N. and Greenberg, D. M. Ibid., 1953,204, 367.PubMedGoogle Scholar
  28. Shive, W. and Rogers, L. L... Ibid., 1947,169, 453.Google Scholar
  29. Steele, B. F., Sauberlich, H. E., Reynolds, M. S. and Baumann, C. A. Ibid., 1949,177, 533.PubMedGoogle Scholar
  30. Utter, M. F. and Kurahashi, K... Ibid., 1954,207, 821.PubMedGoogle Scholar
  31. Weissbach, S. and Sprinson, D. B... Ibid., 1953,203, 1031.PubMedGoogle Scholar
  32. Wessman, C. E. and Werkman, C. H.Arch. Biochem., 1950,26. 214.PubMedGoogle Scholar
  33. Williams, V. R. and Christman, J. F.J. Bact., 1953,65, 238.PubMedGoogle Scholar
  34. Wright, L. D. and Skeggs, H. R...Proc. Soc. Expt. Biol. Med., 1944,56, 95.Google Scholar
  35. Yanofsky, C...J. Biol. Chem., 1953,202, 567.PubMedGoogle Scholar

Copyright information

© Indian Academy of Sciences 1957

Authors and Affiliations

  • G. B. Nadkarni
    • 1
  • A. Sreenivasan
    • 1
  1. 1.Department of Chemical TechnologyUniversity of BombayIndia

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