Reversal by folic acid of penicillin action on growth and on pentose nucleic acid synthesis inLactobacillus Casei
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1. Cells ofL. casei grown in presence of penicillin are found to contain decreased amounts of PNA, DNA being unaffected.
2. PGA by itself and, more effectively, in presence of vitamin B12 exerts protection against the inhibitory action of the antibiotic on growth as well as on PNA formation.
KeywordsSteam Pressure Nucleic Acid Synthesis Nucleic Acid Content Folio Acid Penicillin Solution
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- Bartholomew, J. W. and Umbreit, W. W.J. Bact., 1945,48, 567.Google Scholar
- Bellamy, W. D. and Klimek, J. W. Ibid., 1948,55, 153.Google Scholar
- Boivin, A...Cold Spring Harbor Symp. Quant. Biol., 1947,12, 7.Google Scholar
- Gale, E. F...Selective Toxicity and Antibiotics; Symp. of Soc. of Expt. Biol., 1949,3, 233.Google Scholar
- —— and Rodwell, A...J. Bact., 1948,55, 161.Google Scholar
- Ganapathi, K., Sadasivan, V., Bharucha, F. D. and Radhakrishnan, M. R.Curr. Sci., 1948,17, 263.Google Scholar
- George, M. and Pandalai, K. M.Ind. J. Med. Res., 1948,36, 197.Google Scholar
- Hobby, G. L., Meyer, K. and Chaffee, E.Proc. Soc. Exptl. Biol. Med., 1942,50, 281.Google Scholar
- Krampitz, L. O. and Werkman, C. H.Arch. Biochem., 1947,14, 213.Google Scholar
- Teply, L. J. and Elvehjem, C. A.J. Biol. Chem., 1945,157, 303Google Scholar