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The effect of a single injection of thyroxin on the protein and nucleic acids of the mouse liver and the protein of the mouse carcass

  • A. J. Baxi
  • Kumud D. Samarth
  • P. R. Venkataraman
Article
  • 15 Downloads

Summary

  1. 1.

    Observations have been made concerning the effect of a single dose of thyroxin at a level of 4 mg. per kg. of body weight on the changes in the liver protein and nucleic acids at definite intervals in C-57 strain of mice.

     
  2. 2.

    Except for a marked drop in the liver RNA 6 hours after thyroxin administration, mobilisation of liver protein and nucleic acids take place during a period of active metabolism (18–120 hours after thyroxin administration). Some clear changes in the liver DNA have been also observed during the period of active metabolism.

     
  3. 3.

    There appears to be no quantitative correlation between the mobilisation of protein in the liver and loss of carcass protein, 96 hours after the administration of thyroxin.

     
  4. 4.

    The significance of the observed changes has been presented without prejudice or postulate.

     

Keywords

Total Nitrogen Thyroxin Mouse Liver Initial Body Weight Liver Protein 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Addis, Karnofsky, Lew and PooJ. Biol. Chem., 1938,124, 33.Google Scholar
  2. 2.
    BarnesAm. J. Physiol., 1933,103, 699.Google Scholar
  3. 3.
    Boivin, Vendrely and VendrelyCompt. rend. Acad. d. Sc., 1948,226, 1061.Google Scholar
  4. 4.
    Canzanelli, Rapport and GuildAm. J. Physiol., 1949,157, 225.PubMedGoogle Scholar
  5. 5.
    Chargaff and SaidelJ. Biol. Chem., 1949,177, 417.PubMedGoogle Scholar
  6. 6.
    Clayton, Free, Page, Somers and WoollettBiochem. J., 1950,46, 598.PubMedGoogle Scholar
  7. 7.
    DarlingtonNature (London), 1942,149, 66.CrossRefGoogle Scholar
  8. 8.
    Darlington and La CourJour. Genetics., 1940,40, 185.CrossRefGoogle Scholar
  9. 9.
    Davidson and LeslieCancer Research, 1950,10, 587.PubMedGoogle Scholar
  10. 10.
    DrabkinJ. Biol. Chem., 1950,182, 335.Google Scholar
  11. 11.
    ElmerIodine Metabolism and Thyroid Function, Oxford University Press, London, 1938.Google Scholar
  12. 12.
    Fiske and SubbarowJ. Biol. Chem., 1925,66, 375.Google Scholar
  13. 13.
    Frankel-Conrat and LiEndocrinology, 1949,44, 487.Google Scholar
  14. 14.
    Friedkin and LehningerJ. Biol. Chem., 1949,177, 775.PubMedGoogle Scholar
  15. 15.
    GaddumJ. Physiol., 1930,68, 383.PubMedGoogle Scholar
  16. 16.
    GeitlerChromosomenbau, Protoplasma Monographien, Berlin, 1938.Google Scholar
  17. 17.
    Grad and LeblondAm. J. Physiol., 1950,162, 17.PubMedGoogle Scholar
  18. 18.
    Gross and LeblondJ. Biol. Chem., 1950,184, 489.PubMedGoogle Scholar
  19. 19.
    HuskinsAmer. Nat., 1947,81, 461.CrossRefGoogle Scholar
  20. 20.
    Huskins and SteinitzJour. Hered., 1948,39, 34.Google Scholar
  21. 21.
    KendallEndocrinology, 1919,3, 156.Google Scholar
  22. 22.
    LePage and Umbreit In Umbreit, Burns and Staufer,Manometric Techniques and Related Methods for the Study of Tissue Metabolism, Minneapolis, 1945, 165.Google Scholar
  23. 23.
    LichtmanAnn. Int. Med., 1941,14, 1199.Google Scholar
  24. 24.
    Mirsky and RisNature (London), 1949,163, 666.CrossRefGoogle Scholar
  25. 25.
    Novikoff and PotterJ. Biol. Chem., 1948,173, 223.PubMedGoogle Scholar
  26. 26.
    Pollister and LcuchtenbergerProc. Nat. Acad. Sc., 1949,35, 111.CrossRefGoogle Scholar
  27. 27.
    Ris and MirskyJ. Gen. Physiol., 1949,33, 125.PubMedCrossRefGoogle Scholar
  28. 28.
    Schmidt and ThannhauserJ. Biol. Chem., 1945,161, 83.Google Scholar
  29. 29.
    Schneider —, 1946,164, 747.Google Scholar
  30. 30.
    Schrader and LeuchtenbergerProc. Nat. Acad. Sc., 1949,35, 464.CrossRefGoogle Scholar
  31. 31.
    Sobel, Yuska and CohenJ. Biol. Chem., 1937,118, 443.Google Scholar
  32. 32.
    Spiegelman and KamenCold Spring Harbor Symposia Quant. Biol., 1947,12, 211.Google Scholar
  33. 33.
    SternheimerEndocrinology, 1939,25, 899.Google Scholar
  34. 34.
    Talageri, Samarth, Baxi and VenkataramanBrit. J. Exptl. Path., 1951 (in Press).Google Scholar
  35. 35.
    Vischer, Zamenhof and ChargaffJ. Biol. Chem., 1949,177, 429.PubMedGoogle Scholar
  36. 36.
    Wallach and ReinekeEndocrinology, 1949,45, 75.PubMedGoogle Scholar
  37. 37.
    White and Dougherty —, 1947,41, 230.CrossRefGoogle Scholar

Copyright information

© Indian Academy of Sciences 1951

Authors and Affiliations

  • A. J. Baxi
    • 1
  • Kumud D. Samarth
    • 1
  • P. R. Venkataraman
    • 1
  1. 1.Division of LaboratoriesTata Memorial HospitalBombay

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