Advertisement

Search for physiologically active compounds

Part XII. Synthesis and fungistatic activity of 5: 6- and 5:8-quinoline quinone
  • B. Harinath Babu
  • N. V. Subba Rao
Article
  • 12 Downloads

Abstract

A few 5:6- and 5:8-quinoline quinones have been synthesised by oxidising the corresponding aminohydroxy and diaminoquinolines. The required aminohydroxy quinolines could be prepared by nitrosation of hydroxy quinolines and subsequent reduction. Coupling the monoamino quinolines with diazotised sulphanilic acid and reduction afforded the diamino quinolines. 6:7-Dichloro- and 6:7-dibromo-5:8-quinoline quinones exhibited fungistatic activity nearly equal to that of 2:3-dichloro-1:4-naphthoquinone.

Keywords

Quinone Quinoline Hydroxy Quinoline Sodium Dithionite Fungistatic Activity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Pratt, Y. T. and Drake, N. L.J. Am. Chem. Soc., 1955,77, 37.CrossRefGoogle Scholar
  2. 2.
    Wagner, A., Beck, W. and Diskus, A.Oesterreichische, Stickstoffwerke A. G., Austrian Patent 221,311 (1962);Chem. Abstr., 1962,57, 9823.Google Scholar
  3. 3.
    ----- ..Oesterreichische, Stickstoffwerke, A. G., Austrian Patent 220, 425 (1962);Chem. Abstr., 1962,57, 3420.Google Scholar
  4. 4.
    Willastaedt, H. .. Swed. Patent 129,168 (1950);Chem. Abstr., 1951,45, 3428.Google Scholar
  5. 5.
    Shoji, K...Osaka Daigaku Igaku Zasshi, 1960,12, 621.Google Scholar
  6. 6.
    Schellhammer, C. W. and Patterson, S.Ann., 1959,624, 108.Google Scholar
  7. 7.
    Farbenfabriken Bayer, A. G. British Patent 874,770 (1960);Chem. Abstr., 1961,56, 5968.Google Scholar
  8. 8.
    ----- .. British Patent 864,747 (1961);Chem. Abstr., 1961,55, 25994.Google Scholar
  9. 9.
    Pratt, Y. L. and Drake, N. L.J. Am. Chem. Soc., 1957,79, 5024.CrossRefGoogle Scholar
  10. 10.
    Gilman, H...Organic Synthesis, John Wiley & Sons, Inc., New York, 1944, Col.2, 173.Google Scholar
  11. 11.
    Fujita, E., Orishi, K. and Waki, N.J. Pharm. Soc. Japan, 1956,76, 817.Google Scholar
  12. 12.
    —— and Waki, N...Yokugaku Zasshi, 1957,77, 750.Google Scholar
  13. 13.
    Richter, F. and Smith, G. F.J. Am. Chem., Soc. 1944,66, 397.CrossRefGoogle Scholar
  14. 14.
    Long, R. and Schofield, K.J. Chem. Soc., 1953, 3161.Google Scholar
  15. 15.
    Pratt, Y. L. and Drake, N. L.J. Am. Chem. Soc., 1960,82, 1155.CrossRefGoogle Scholar
  16. 16.
    Urbansky, T. and Krzyzanowski, S.Roczniki Chem., 1953,27, 390.Google Scholar
  17. 17.
    Badger, G. M. and Sasse, W. F. H.J. Chem. Soc., 1957, 4.Google Scholar
  18. 18.
    Gilman, H...Organic Synthesis, John Wiley & Sons, Inc., New York, 1944, Coll,2, 33.Google Scholar
  19. 19.
    Johnson, O. H. and Hamilton, C. S.J. Am. Chem. Soc., 1941,63, 2865.Google Scholar
  20. 20.
    McGookin, A. and Swift, S. R.J. Soc. Chem. Ind., 1939,58, 152.CrossRefGoogle Scholar

Copyright information

© Indian Academy of Sciences 1968

Authors and Affiliations

  • B. Harinath Babu
    • 1
  • N. V. Subba Rao
    • 1
  1. 1.Department of ChemistryOsmania UniversityHyderabad-7

Personalised recommendations