Mitochondrial oxidative phosphorylation and respiratory chain: Review
- 226 Downloads
Basic events concerning oxidative phosphorylation, i.e. the synthesis of ATP at the expense of respired oxygen at the level of mitochondria are described. Our knowledge concerning the functioning of respiratory chain, its structure, organization and topology inside the inner membrane of mitochondria has considerably improved in recent years. A central question — how does the respiratory chain cooperate with ATP-synthetase, also embedded in the inner membrane, to bring about the oxidative phosphorylation of ADP to ATP — has been one of the most challenging and difficult problems in biochemical research. The chemiosmotic hypothesis proposed by the British biochemist Peter Mitchell appears best in describing the basic events of the recovery of the redox energy liberated along the respiratory chain to synthesize ATP through a membrane process. Moreover the chemiosmotic hypothesis is not restricted to mitochondrial oxidative phosphorylation but appears to provide a general explanation to the synthesis of ATP in all transducing membranes: inner mitochondrial membrane, bacterial plasma membrane, thylakoid membranes in chloroplasts of green plants.
KeywordsOxidative Phosphorylation Respiratory Chain Oligomycin Mitochondrial Oxidative Phosphorylation Proton Channel
Unable to display preview. Download preview PDF.
- Belitzer, V. A. and Tsibakova, E. T. The mechanism of phosphorylation associated with respiration.Biokimiia 4 (1939) 516–526Google Scholar
- Chance, B. and Williams, G. R. The respiratory chain and oxidative phosphorylation.Adv. Enzymol. 17 (1956) 65–134Google Scholar
- Hatefi, Y. The enzymes and the enzyme complexes of the mitochondrial oxidative phosphorylation system. In Martonosi, A. (ed.)The Enzymes of Biological Membranes, Plenum Press, New York, 1976, Vol. 4, pp. 3–41Google Scholar
- Keilin, D.The History of Cell Respiration and Cytochromes, Cambridge University Press, London, 1966Google Scholar
- Krebs, H. A. and Johnson, W. A. The role of citric acid in intermediary metabolism in animal tissue.Enzymologia 4 (1937) 148Google Scholar
- Racker, E.A New Look at Mechanisms in Bioenergetics, Academic Press, New York, 1976.Google Scholar
Books and General Reviews
- Lehninger, A. L.The Mitochondrion: Molecular Basis of Structure and Function, Benjamin, 1965, New YorkGoogle Scholar
- Lehninger, A. L. Mitochondria and biological mineralization processes: an exploration. In E. Quagliariello, F. Palmieri and T. Singer, eds.Horizons in Biochemistry and Biophysics, vol. 4 (1977) pp. 1–30, Addison-Wesley, Reading, MassGoogle Scholar
- Tzagoloff, A.Mitochondria, 1982, Plenum Press, New York.Google Scholar