Skip to main content
SpringerLink
Log in

Glomerulonephritis und malignes Lymphom

Glomerulonephritis and lymphoma — Mostly men with low-grade lymphoma with various forms of glomerulonephritis are affected

Überwiegend Männer mit niedrigmalignem Lymphom mit unterschiedlichen glomerulonephritisformen

  • Kasuistik
  • Published:
Medizinische Klinik - Intensivmedizin und Notfallmedizin Aims and scope Submit manuscript

Zusammenfassung

□ Hintergrund

Gleichzeitiges Vorkommen von malignen Lymphomen und verschiedenen Glomerulonephritisformen ist lange bekannt. Während aber die Hodgkinsche Erkrankung oft zusammen mit “Minimal-change”-Glomerulonephritis auftritt, finden sich bei den Non-Hodgkin-Lymphomen ganz unterschiedliche Glomerulonephritisformen.

□ Patienten und Ergebnisse

Es werden drei Fälle von Non-Hodgkin-Lymphomen mit unterschiedlichen Glomerulonephritiden beschrieben. Zwei Glomerulonephritiden gingen mit nephrotischem Syndrom einher, das sich unter symptomatischer Behandlung besserte. In zwei Fällen manifestierten sich Glomerulonephritis und Non-Hodgkin-Lymphom gleichzeitig, im dritten Fall trat die Glomerulonephritis erst drei Jahre nach der Lymphomdiagnose auf.

□ Schlußfolgerung

Aus diesen und in der Literatur belegten Fällen läßt sich schließen, daß die Vielzahl beschriebener Syntropien für Abhängigkeiten zwischen Non-Hodgkin-Lymphomen und Glomerulonephritis spricht. Bei Männern scheint die Assoziation häufiger zu sein. Niedrigmaligne Non-Hodgkin-Lymphome, insbesondere chronische lymphatische Leukämien, gehen häufiger mit Glomerulonephritis einher als hochmaligne Formen. Selten weisen Non-Hodgkin-Lymphome eine Bevorzugung bestimmter Glomerulonephritistypen auf. Lediglich kutane Non-Hodgkin-Lymphome gehen häufiger mit IgA-Nephritiden einher. Die pathogenetischen Zusammenhänge einer Syntropie von malignen Lymphomen und Glomerulonephritiden sind allerdings bisher nur unzureichend geklärt.

Summary

□ Background

The association of non-Hodgkin’s lymphoma with different types of glomerulonephritis is well-known for many years. Whereas in Hodgkin’s disease, minimal change glomerulonephritis is mainly observed, in non-Hodgkin’s lymphoma various forms of glomerulonephritis are found.

□ Patients and Results

We describe 3 cases of non-Hodgkin’s lymphoma, which were assoicated with glomerulonephritis. Two cases of glomerulonephritis nephritis showed nephrotic syndromes, which improved by medicinal treatment. In 2 cases glomerulonephritis and non-Hodgkin’s lymphoma developed simultaneously. In a third lymphoma was followed by glomerulonephritis after 3 years.

□ Conclusion

Although the pathogenetic relationship between non-Hodgkin’s lymphoma and glomerulonephritis is not fully understood, the high number of reported cases yield interdependence. Lymphoma associated glomerulonephritis is found more often in men than in women. Low-grade non-Hodgkin’s lymphomas — especially chronic lymphatic leukemias — seem to develop glomerulonephritis more rrequently than high-grade. The majority of non-Hodgkin’s lymphoma do not show any predisposition to a special type of glomerulonephrits, only in cutaneous lymphoma IgA-nephropathy predominates.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Literatur

  1. Allon, M., W. Campbell, S. Nasr, E. Bourke, J. Stoute, J. Guntupalli: Minimal change glomerulonephropathy and interstitial infiltration with mycosis fungoides. Amer. J. Med. 84 (1988), 756–759.

    CAS  PubMed  Google Scholar 

  2. Banks, R., J. Kingswood, R. Slade, C. Tribe, P. Harison, J. Mackenzie: Glomerulonephritis, non-Hodgkin’s lymphoma and leucocytoplastic vasculitis. Amer. J. Nephrol. 4 (1984), 114–117.

    CAS  Google Scholar 

  3. Belghiti, D., J. Vernant, G. Hirbec, M. Gubler, C. Andre, A. Sobel: Nephrotic syndrome associated with T-cell lymphoma. Cancer 47 (1982), 1878–1882.

    Google Scholar 

  4. Biava, C., T. Gonwa, J. Naughton, J. Hopper: Crescentic glomerulonephritis associated with nonrenal malignancies. Amer. J. Nephrol. 4 (1984), 208–214.

    CAS  Google Scholar 

  5. Brodovsky, H., M. Samuels, P. Migliore, C. Howe: Chronic lymphatic leukemia, Hodgkin’s disease and the nephrotic syndrome. Arch. intern. Med. 121 (1968), 71–75.

    CAS  PubMed  Google Scholar 

  6. Cronin, C., E. Carmody, F. Ryan, M. Camody: Acute renal failure and non-Hodgkins lymphoma in a patient with minimal change glomerulonephritis. J. intern. Med. 228 (1990), 65–68.

    CAS  PubMed  Google Scholar 

  7. Dabbs, D., L. Striker, F. Mignon, G. Striker: Glomerular lesions in lymphomas and leukemias. Amer. J. Med. 80 (1986), 63–70.

    CAS  PubMed  Google Scholar 

  8. Dixon, F., J. Feldman, J. Vazquez: Experimental glomerulonephritis. The pathogenesis of a laboratory model resembling the spectrum of human glomerulonephritis. J. exp. Med. 113 (1961), 899–920.

    CAS  PubMed  PubMed Central  Google Scholar 

  9. Duwaji, M., D. Shemin, L. Medeitos, A. Esparza: Proliferative glomerulonephritis with unusual, organized, cylindrical deposits associated with angioimmunoblastic lymphadenopathy-like T-cell lymphoma Arch. Path. Lab. Med. 11 (1995), 377–380.

    Google Scholar 

  10. Edgington T., R. Glassock, F. Dixon: Autologous immune complex pathogenesis of experimental allergic glomerulonephritis. Science 155 (1967), 1432–1434.

    CAS  PubMed  Google Scholar 

  11. Espinosa, E., J. Martinez Ara, M. Picazo, P. Zamor: Lymphoma and type I membrano-proliferative glomerulonephritis — a case report. Acta oncol. 32 (1993), 460–461.

    CAS  PubMed  Google Scholar 

  12. Flury, W., E. Wegmüller, T. Zeltner, P. Niesel: Malignes Non-Hodgkin-Lymphom mit Visusstörung und nephrotischem Syndrom. Schweiz. med. Wschr. 112 (1982), 448–453.

    CAS  PubMed  Google Scholar 

  13. Frehally, J., R. Hutchinson, E. Mackay, J. Walls: Recurrent proteinuria in chronic lymphatic leukemia. Clin. Nephrol. 16 (1981), 51–54.

    Google Scholar 

  14. Gärtner, H., P. Pack, M. Hanatani, N. Settgast, R. Wanninger, R. Lederle, C. Erley, E. Mikeler: Membranoproliferative glomerulonephritis in Non-Hodgkin’s lymphoma and myeloproliferative syndrome — a causal relationship? Verh. dtsch. Ges. Path. 75 (1991), 229–234.

    Google Scholar 

  15. Gagliano, R., J. Costanzi, G. Beathard, H. Sarles, J. Bell: The nephrotic syndrome associated with neoplasia: an unusual paraneoplastic syndrome. Report of a case and review of the literature. Amer. J. Med. 60 (1976), 1026–1031.

    CAS  PubMed  Google Scholar 

  16. Ghosh, L., R. Muehrcke: Nephrotic syndrome: a prodrome to lymphoma. Ann. intern. Med. 72 (1970), 379–382.

    CAS  PubMed  Google Scholar 

  17. Gilboa, N., D. Durante, S. Guggenheim, J. Lacher, R. Holman, W. Schorr, D. Garfield, R. McIntosh: Immune deposit nephritis and siegle component cryoglobulinemia associated with chronic lymphatic leukemia. Nephron 24 (1979), 223–231.

    CAS  PubMed  Google Scholar 

  18. Giron Gonzalez, J., M. Yebra Bango, F. Merino Morales, J. Menendez Caro, F. Diego Marin, A. Durantez Martinez: The association of non-Hodgkins lymphoma with glomerulonephritis. Postgrad. med. J. 62 (1986), 1141–1145.

    CAS  PubMed  PubMed Central  Google Scholar 

  19. Gupta, K., V. Sakhuja, B. Radotra, P. Singh, K. Chugh: Necrotising glomerulonephritis and non-Hodgkin’s lymphoma associated with rheumatoid arthritis. Nephrol. Dialys. Transplant. 5 (1990), 385–387.

    CAS  Google Scholar 

  20. Herskowitz, L., R. Gottlieb, S. Travis: Nephrotic syndrome associated with non-Hodgkin’s lymphoma. Clin. Pediat. (Phila.) 21 (1982), 441–443.

    CAS  Google Scholar 

  21. Hyman, L., P. Burkholder, P. Joo, W. Segar: Malignant lymphoma and nephrotic syndrome. J. Pediat. 82 (1973), 207–212.

    CAS  PubMed  Google Scholar 

  22. Ito, M., J. Cui, M. Hotchi, M. Nagasaki: An autopsied case of a malignant lymphoma with severe nephrotic syndrome overlapped by cirrhotic glomerulosclerosis. Gan No Rinsho 34 (1988), 938–945.

    CAS  PubMed  Google Scholar 

  23. Jacobs, P., M. Hayes, S. King, M. Dent: Unusual clinical presentation of intermediate lymphocytic lymphoma. Centr. Afr. J. Med. 35 (1989), 467–480.

    Google Scholar 

  24. Jacquot, C., D. Nochy, C. d’Auzac, A. Durandy, A. Regnier, M. Lemann, P. Druet, J. Bariety: Glomerulonephritis, B monoclonal small lymphocytic lymphoma and mixed cryoglobulinemia. Clin. Nephrol. 27 (1987), 263–268.

    CAS  PubMed  Google Scholar 

  25. Kaplan, B., J. Klassen: Glomerular injury in patients with neoplasia. Ann. Rev. Med. 27 (1976), 117–125.

    CAS  PubMed  Google Scholar 

  26. Kerkhoven, P., J. Briner, A. Blumberg: Nephrotisches Syndrom als Erstmanifestation maligner Lymphome. Schweiz. med. Wschr. 103 (1973), 1706–1707.

    CAS  PubMed  Google Scholar 

  27. Keur, I., R. Krediet, L. Arisz: Glomerulopaty as a paraneoplastic phenomenon. Neth. J. Med. 34 (1989), 270–284.

    CAS  PubMed  Google Scholar 

  28. Klette, H.: Assoziierte Glomerulonephritis beim Immunozytom. Z. ges. Inn. Med. 43 (1988), 488–491.

    CAS  PubMed  Google Scholar 

  29. Kohan, D., S. Perkins, D. Terreros: Immune complex glomerulonephritis with unusual microfibrillar deposits associated with primary bone marrow lymphoma. Amer. J. Kidney Dis. 21 (1993), 47–51.

    CAS  Google Scholar 

  30. Lee, J., H. Yamauchi, J. Hopper: The association of cancer and the nephrotic syndrome. Ann. intern. Med. 64 (1966), 41–51.

    CAS  PubMed  Google Scholar 

  31. Leroux, D., P. Seite, J. Hillion, F. Le Marc’hadour, B. Pegourie Bandelier, M. Jacob, C. Larsen, J. Sotto: t(11;18) (q21;q21) may delineate a spectrum of diffuse small B-cell lymphoma with extranodal involvement. Gen. chromosom. Cancer 7 (1993), 54–56.

    CAS  Google Scholar 

  32. Matsui, M., M. Matsuzaki, Y. Shimamoto, M. Shigyo, M. Uchida, K. Ono, M. Sano, T. Sakemi, M. Yamaguchi: Malignant lymphoma with acute renal failure and nephrotic syndrome. Jap. J. clin. Hematol. 31 (1990), 229–233.

    CAS  Google Scholar 

  33. Moe, S., J. Baron, S. Coventry, C. Dolan, J. Umans: Glomerular disease and urinary Sezary cells in cutaneous T-cell lymphomas. Amer. J. Kidney Dis. 21 (1993), 545–547.

    CAS  Google Scholar 

  34. Moorthy, V., S. Zimmerman, P. Burkholder: Nephrotic syndrome in Hodgkin’s disease — evidence for pathogenesis alternative to immune complex deposition. Amer. J. Med. 61 (1976), 471–477.

    CAS  PubMed  Google Scholar 

  35. moulin, B., P. Ronco, B. Mougenot, A. Francois, J. Fillastre, F. Mignon: Glomerulonephritis in chronic lymphocytic leukemia and related B-cell lymphomas. Kidney int. 42 (1992), 127–135.

    CAS  PubMed  Google Scholar 

  36. Muggia, F., J. Ultmann: Glomerulonephritis or nephrotic syndrome in malignant lymphoma, reticulum-cell type. Lancet 1 (1971), 805.

    CAS  PubMed  Google Scholar 

  37. Munker, R., W. Nathrath, W. Permanetter, J. Gokel: Lennert-Lymphom und Glomerulonephritis. Dtsch. med. Wschr. 116 (1991), 1136–1140.

    CAS  PubMed  Google Scholar 

  38. Petzel, R., D. Brown, N. Staley, J. McMillen, R. Sibley, C. Kjellstrand: Crescentic glomerulonephritis and renal failure associated with malignant lymphoma. Amer. J. clin. Path. 71 (1979), 728–732.

    CAS  Google Scholar 

  39. Poch, E., J. Almirall, A. Torras, J. Ordi, A. Darnell, L. Revert: Rapidly progressive glomerulonephritis and systemic vasculitis in Non-Hodgkin lymphoma. Nephrol. dial. Transplant. 6 (1991), 51–54.

    CAS  PubMed  Google Scholar 

  40. Pollock, C., L. Ibels, J. Levi, R. Eckstein, P. Wakeford: Acute renal failure due to focal necrotizing glomerulonephritis in a patient with non-Hodgkin’s lymphoma. Nephron 48 (1988), 197–200.

    CAS  PubMed  Google Scholar 

  41. Rabkin, R., G. Thatcher, L. Diamond L. Eales: The nephrotic syndrome, malignancy and immunosuppression. S. Afr. med. J. 47 (1973), 605–606.

    CAS  PubMed  Google Scholar 

  42. Ramirez, G., J. Stinson, E. Zawada, F. Moatamed: IgA nephritis associated with mycosis fungoides — report of two cases. Arch. intern. Med. 141 (1981), 1287–1291.

    CAS  PubMed  Google Scholar 

  43. Ras, E., J. Michaeli, E. Rosenmann, M. Popovtzer, A. Polliack, D. Shouval: Excessive hepatitis-B surface antigen production after corticosteroids and the development of immunoblastic lymphoma. Leuk. Lymph. 10 (1993), 241–244.

    CAS  Google Scholar 

  44. Rault, R., J. Holley, B. Banner, M. El-Shahawy: Glomerulonephritis and non-Hodgkin’s lymphoma: a report of two cases and review of the literature Amer. J. Kidney Dis. 20 (1992), 84–89.

    CAS  Google Scholar 

  45. Reutter, F.: Legionärskrankheit, tumorassoziiertes nephrotisches Syndrom, primäre Oxalose (klinische Demonstrationen). Schweiz. med. Wschr. 111 (1981) 1883–1893.

    CAS  PubMed  Google Scholar 

  46. Rollino, C., A. Dieny, F. Le Marc’hadour, J. Renversez, N. Pinel, D. Cordonnier: Double monoclonal cryoglobulinemia, glomerulonephritis and lymphoma. Nephron 62 (1962), 459–464.

    Google Scholar 

  47. Rosenmann, E., M. Brisson, D. Bercovitch, A. Rosenberg: Atypical membranous glomerulonephritis with fibrillar subendothelial deposits in a patient with malignant lymphoma. Nephron 48 (1988), 226–230.

    CAS  PubMed  Google Scholar 

  48. Row, P., J. Cameron, D. Turner, D. Evans, R. White, C. Ogg, C. Chantler, C. Brown: Membranous nephropathy long-term follow-up and association with neoplasia. Ateneo Parmense Acta Biomed. 46 (1975), 433–454.

    CAS  PubMed  Google Scholar 

  49. Sagel, J., H. Muller, E. Logan: Lymphoma and the nephrotic syndrome. S. Afr. med. J. 45 (1971), 79–80.

    CAS  PubMed  Google Scholar 

  50. Schurgers, M., W. Pauwels, M. Praet, J. Quatacker, N. Lameire: A 47 year old man with lymphadenopathy and renal failure (clinical conference). Acta clin. belg. 43 (1988), 149–157.

    CAS  PubMed  Google Scholar 

  51. Seney, F., W. Federgreen, H. Stein, M. Kashgarian: A review of nephrotic syndrome associated with chronic lymphocytic leukemia. Arch. intern. Med. 146 (1986), 137–141.

    PubMed  Google Scholar 

  52. Späth, M., P. Schollmeyer: T-Zell-Lymphom unter Immunsuppression bei “minimal-change” Glomerulopathie mit nephrotischem Syndrom. Dtsch. med. Wschr. 120 (1995), 1161–1165.

    PubMed  Google Scholar 

  53. Strippoli, P., S. De Marco, A. Marinosci, F. Spedicato, A. Scatizzi: Chronic lymphatic leukemia and membranoproliferative glomerulonephritis. Haematologica 67 (1982), 805–807.

    CAS  PubMed  Google Scholar 

  54. Torrelo, A., M. Rivera, F. Mampaso, A. Espana, R. Marcen, J. Ortuno, A. Ledo: Immunotactoid glomerulopathy associated with mycosis fungoides. Postgrad. med. J. 66 (1990), 773–775.

    CAS  PubMed  PubMed Central  Google Scholar 

  55. Traynor, A., T. Kuzel, E. Samuelson, Y. Kanwar: Minimalechange glomerulopathy and glomerular visceral epithelial hyperplasia associated with alpha-interferon therapy for cutaneous T-cell lymphoma. Nephron 67 (1994), 94–100.

    CAS  PubMed  Google Scholar 

  56. Weber, B., M. Mihatsch, R. Streuli: Petechien, Mikrohämaturie, kolikartige Abdominalschmerzen. Schweiz. Rundsch. med. Prax. 79 (1990) 809–812.

    CAS  PubMed  Google Scholar 

  57. Weinstein, T., A. Chagnac, U. Gafter, D. Zevin, R. Gal, M. Djaldetti, J. Levi: Unusual case of crescentic glomerulonephritis associated with malignant lymphoma. Amer. J. Nephrol. 10 (1990), 329–332.

    CAS  Google Scholar 

  58. Yaganita, N., H. Yokoi, J. Koide, M. Toriyama, T. Ishii: Acute bilateral deafness with nephritis: a human temporal home study. Laryngoscope 97 (1987), 345–352.

    Google Scholar 

  59. Yamazaki, Y., S. Inaba, T. Nemoto, K. Iizuka, T. Fujikawa, J. Horiguchi, H. Yamada: Acute renal failure due to endocapillary proliferative glomerulonephritis in a patient with IBL-like-T-cell lymphoma. Rinsho Ketsueki 32 (1991), 796–801.

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Klinik für Hämatologie, Onkologie und klinische Immunologie der Heinrich-Heine-Universität Düsseldorf, Düsseldorf, Deutschland

    Johannes Zahner & Wolfgang Schneider

  2. Klinik für Nephrologie und Rheumatologie der Heinrich-Heine-Universität Düsseldorf, Düsseldorf, Deutschland

    Dieter Bach & Bernd Grabensee

  3. Institut für diagnostische Rachologie der Heinrich-Heine-Universität Düsseldorf, Düsseldorf, Deutschland

    Jürgen Malms

  4. Hautklinik der Heinrich-Heine-Universität Düsseldorf, Düsseldorf, Deutschland

    Karsten Diercks

  5. Medizinische Klinik a der Universität, Moorenstraße 5, D-40225, Düsseldorf

    Johannes Zahner

Authors
  1. Johannes Zahner
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Dieter Bach
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Jürgen Malms
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Wolfgang Schneider
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Karsten Diercks
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Bernd Grabensee
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Zahner, J., Bach, D., Malms, J. et al. Glomerulonephritis und malignes Lymphom. Med. Klin. 92, 712–719 (1997). https://doi.org/10.1007/BF03044667

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF03044667

Schlüsselwörter

Key Words

Search

Navigation