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Medizinische Klinik

, 92:712 | Cite as

Glomerulonephritis und malignes Lymphom

Überwiegend Männer mit niedrigmalignem Lymphom mit unterschiedlichen glomerulonephritisformen
  • Johannes Zahner
  • Dieter Bach
  • Jürgen Malms
  • Wolfgang Schneider
  • Karsten Diercks
  • Bernd Grabensee
Kasuistik

Zusammenfassung

□ Hintergrund

Gleichzeitiges Vorkommen von malignen Lymphomen und verschiedenen Glomerulonephritisformen ist lange bekannt. Während aber die Hodgkinsche Erkrankung oft zusammen mit “Minimal-change”-Glomerulonephritis auftritt, finden sich bei den Non-Hodgkin-Lymphomen ganz unterschiedliche Glomerulonephritisformen.

□ Patienten und Ergebnisse

Es werden drei Fälle von Non-Hodgkin-Lymphomen mit unterschiedlichen Glomerulonephritiden beschrieben. Zwei Glomerulonephritiden gingen mit nephrotischem Syndrom einher, das sich unter symptomatischer Behandlung besserte. In zwei Fällen manifestierten sich Glomerulonephritis und Non-Hodgkin-Lymphom gleichzeitig, im dritten Fall trat die Glomerulonephritis erst drei Jahre nach der Lymphomdiagnose auf.

□ Schlußfolgerung

Aus diesen und in der Literatur belegten Fällen läßt sich schließen, daß die Vielzahl beschriebener Syntropien für Abhängigkeiten zwischen Non-Hodgkin-Lymphomen und Glomerulonephritis spricht. Bei Männern scheint die Assoziation häufiger zu sein. Niedrigmaligne Non-Hodgkin-Lymphome, insbesondere chronische lymphatische Leukämien, gehen häufiger mit Glomerulonephritis einher als hochmaligne Formen. Selten weisen Non-Hodgkin-Lymphome eine Bevorzugung bestimmter Glomerulonephritistypen auf. Lediglich kutane Non-Hodgkin-Lymphome gehen häufiger mit IgA-Nephritiden einher. Die pathogenetischen Zusammenhänge einer Syntropie von malignen Lymphomen und Glomerulonephritiden sind allerdings bisher nur unzureichend geklärt.

Schlüsselwörter

Niedrigmalignes Lymphom Non-Hodgin-Lymphom Glomerulonephritis 

Glomerulonephritis and lymphoma — Mostly men with low-grade lymphoma with various forms of glomerulonephritis are affected

Summary

□ Background

The association of non-Hodgkin’s lymphoma with different types of glomerulonephritis is well-known for many years. Whereas in Hodgkin’s disease, minimal change glomerulonephritis is mainly observed, in non-Hodgkin’s lymphoma various forms of glomerulonephritis are found.

□ Patients and Results

We describe 3 cases of non-Hodgkin’s lymphoma, which were assoicated with glomerulonephritis. Two cases of glomerulonephritis nephritis showed nephrotic syndromes, which improved by medicinal treatment. In 2 cases glomerulonephritis and non-Hodgkin’s lymphoma developed simultaneously. In a third lymphoma was followed by glomerulonephritis after 3 years.

□ Conclusion

Although the pathogenetic relationship between non-Hodgkin’s lymphoma and glomerulonephritis is not fully understood, the high number of reported cases yield interdependence. Lymphoma associated glomerulonephritis is found more often in men than in women. Low-grade non-Hodgkin’s lymphomas — especially chronic lymphatic leukemias — seem to develop glomerulonephritis more rrequently than high-grade. The majority of non-Hodgkin’s lymphoma do not show any predisposition to a special type of glomerulonephrits, only in cutaneous lymphoma IgA-nephropathy predominates.

Key Words

Low-grade lymphoma Non-Hodgkin’s lymphoma Glomeru-lonephritis 

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Copyright information

© Urban & Vogel 1997

Authors and Affiliations

  • Johannes Zahner
    • 1
    • 5
  • Dieter Bach
    • 2
  • Jürgen Malms
    • 3
  • Wolfgang Schneider
    • 1
  • Karsten Diercks
    • 4
  • Bernd Grabensee
    • 2
  1. 1.Klinik für Hämatologie, Onkologie und klinische Immunologie der Heinrich-Heine-Universität DüsseldorfDüsseldorfDeutschland
  2. 2.Klinik für Nephrologie und Rheumatologie der Heinrich-Heine-Universität DüsseldorfDüsseldorfDeutschland
  3. 3.Institut für diagnostische Rachologie der Heinrich-Heine-Universität DüsseldorfDüsseldorfDeutschland
  4. 4.Hautklinik der Heinrich-Heine-Universität DüsseldorfDüsseldorfDeutschland
  5. 5.Medizinische Klinik a der UniversitätDüsseldorf

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