Anmerkungen zum Beitrag von Reinhard Länge et al. ‘Kriterien zur Bewertung der Qualität und Validität von toxikologischen und ökotoxikologischen Studien für regulatorische Fragestellungen’ [UWSF 18 (1) 49–54 (2006)]

Briefe an den Herausgeber


  1. Arnold SF, Klotz DM, Collins BM, Vonier PM, Guillette LJ Jr, McLachlan JA (1996): Synergistic activation of estrogen receptor with combinations of environmental chemicals. Science 272, 1489–1492CrossRefGoogle Scholar
  2. Ashby J, Tinwell H, Haseman J (1999): Lack of effects for low dose levels of bisphenol A and diethylstilbestrol on the prostate gland of CF1 mice exposed in utero. Regul Toxicol Pharmacol 30, 156–166CrossRefGoogle Scholar
  3. Cagen SZ, Waechter JM Jr, Dimond SS, Breslin WJ, Butala JH, Jekat FW, Joiner RL, Shiotsuka RN, Veenstra GE, Harris LR (1999): Normal reproductive organ development in CF-1 mice following prenatal exposure to Bisphenol A. Toxicol Sci 50, 36–44CrossRefGoogle Scholar
  4. Diethelm PA, Rielle JC, McKee M (2005): The whole truth and nothing but the truth? The research that Philip Morris did not want you to see. Lancet 366, 86–92CrossRefGoogle Scholar
  5. Länge R, Caspers N, Ensenbach U, Pallapies D, Zok S (2006): Kriterien für die Bewertung der Qualität und Validität von toxikologischen und ökotoxikologischen Studien für regulatorische Fragestellungen. UWSF- Z Umweltchem Ökotox 18 (1) 49–54Google Scholar
  6. Michaels D (2005): Doubt is their Product. Scientific American, June 2005, 96–105Google Scholar
  7. Sohoni P, Tyler CR, Hurd K, Caunter J, Hetheridge M, Williams T, Woods C, Evans M, Toy R, Gargas M, Sumpter JP (2001): Reproductive effects of long-term exposure to Bisphenol A in the fathead minnow (Pimephales promelas). Environ Sci Technol 35, 2917–2925CrossRefGoogle Scholar
  8. Tyl RW, Myers CB, Marr MC, Thomas BF, Keimowitz AR, Brine DR, Veselica MM, Fail PA, Chang TY, Seely JC, Joiner RL, Butala JH, Dimond SS, Cagen SZ, Shiotsuka RN, Stropp GD, Waechter J (2002): Three-generation reproductive toxicity study of dietary bisphenol A in CD Sprague-Dawley rats. Toxicol Sci 68, 121–146CrossRefGoogle Scholar
  9. US EPA (2005): EPA Settles PFOA Case Against DuPont for Largest Environmental Administrative Penalty in Agency History. Press release: <!OpenDocument>, Zugang: 26. Jan. 2006Google Scholar
  10. Vom Saal FS, Timms BG, Montano MM, Palanza P, Thayer K, Nagel SC, Dhar MD, Ganjam VK, Parmigiani S, Welshons WV (1997) Prostate enlargement in mice due to fetal exposure to low doses of estradiol or diethylstilbestrol and opposite effects in high doses. Proc Natl Acad Sci 94, 2056–2061CrossRefGoogle Scholar
  11. Vom Saal FS, Cooke PS, Buchanan DJ, Palanza P, Thayer K, Nagel SC, Parmigiani S, Welshons WV (1998): A physiological basedapproach to the study of bisphenol A and other estrogenic chemicals on the size of reproductive organs, daily sperm production and behavior. Toxicol Indust Health 14, 239–260Google Scholar

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© Springer-Verlag Gmbh 2006

Authors and Affiliations

  1. 1.Abteilung RisikobeurteilungUmweltbundesamtDessau

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