A study on the influence of preoperative radiotherapy to proliferating cell nuclear antigen (PCNA) for oral cancer cells
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The average pretreatment PCNA positive rate was 33.4±11.4% while the average posttreatment rate was 24.0±7.9%.
Subjects were classified according to the degree of differentiation for pretreatment and posttreatment comparison. However, there existed no significant difference in PCNA positive rate.
Subjects were classified according to stage of oral cancer for pretreatment and posttreatment comparsion, however there existed no significant difference in PCNA positive rate.
When the decrease in PCNA rate was compared between the group showing negative irradiation effects and that showing positive effects, the fact that the latter group showed remarkably greater decrease in PCNA rate, indicated a significant difference between the two groups.
Pretreatment PCNA positive rate was higher in the group showing positive irradiation effects than in that showing negative effects and the difference was significant between the two groups. Beneficial effects of irradiation therapy could be expected in those who showed pretreatment PCNA positive rates of more than 30.0%.
The accuracy rate for giagnosis based on PCNA positive rate, and macroscopic and histologic judgment was 58.3%.
Key wordsOral cancer Proliferating cell nuclear antigen (PCNA) Preoperative radiotherapy PCNA positive rate Histological irradiation effect Immunohistochemistry
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