Deoxynivalenol in pigs: An exclusive effect on the appetite?
- 78 Downloads
A feeding-trial was conducted to determine the effects of a deoxynivalenol (DON)-contaminated diet in growing pigs. DON was added as either the purified toxin or as naturally contaminated wheat. Growth performance, biochemical and hematological parameters and DON-transformation through intestinal bacteria were monitored throughout the study. Epithelial tissues along the gastro-intestinal tract were also examined for pathological changes and selected enzyme activities (oxoglutarat dehydrogenase, alanine-amino-transferase). There were no differences among the dietary treatments in all parameters measured except for feed intake and weight gain in the naturally contaminated diets fed ad libitum. Effectsin vivo could not be explained exclusively by cytotoxicity of DON foundin vitro. These observations may reflect the presence of other unidentified (toxic) compounds in the naturally contaminated grain or the influence of further factors. In future studies synergistic/additive interactions with substances promoting appetite should be taken into consideration.
KeywordsDeoxynivalenol natural contamination pure DON weight gain pig histopathology serum IgA
Unable to display preview. Download preview PDF.
- 6.Friend DW, Trenholm HL, Thompson BK, Fiser PS, Hartin KE (1986) Effect of feeding diets containing deoxynivalenol (vomitoxin)-contaminated wheat or corn on the feed consumption, weight gain, organ weight and sexual development of male and female pigs. Can. J. Anim. Sci. 66 (3): 765–775CrossRefGoogle Scholar
- 9.Dillenburger T, Lauber U, Schollenberger M, Müller HM, Drochner W (2000) Wirkung von Deoxynivalenol beim wachsenden Schwein in Abhängigkeit von der Darreichungsform. Proceedings of 22. Mykotoxin-Workshop, 5.–7. June 2000, Bonn, Germany, Mycotox. Res. 16A(2): 170–173Google Scholar
- 11.Madaj M, Lundh T, Lindberg JE (1999) Effect of exposure to dietary Nivalenol on activity of enzymes involved in glutamine catabolism in the epithelium along the gastrointestinal tract of growing pigs. Arch. Anim. Nutr. 00: 1–10Google Scholar