Conditional Reflex

, Volume 2, Issue 2, pp 113–117 | Cite as

Gallbladder distention and the effects of several drugs on heart rate, respiratory movements and cortical potentials in cats with hypothalamic lesions

  • W. Rüdiger
  • M. Lindemann


The effects of chronic hypothalamic lesions and various drugs on the viscero-visceral reflexes of cats have been investigated, utilizing measurement of the bioelectrical activity of the cerebral cortex. After coagulation of the posterolateral hypothalamus the heart rate decreased by 40–60 beats per minute, but eventually it regained its initial value. The viscero-visceral reflexes from the gallbladder to the heart were preserved after the operative procedure. Chlorpromazine and atropine blocked both arousal and the cardiorespiratory response to stimulation of the gallbladder. Similar effects were produced by novocaine and pantocaine.


Cerebral Cortex Chlorpromazine Mechanical Stimulation Respiratory Movement Cortical Potential 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Bykov, K. M.: Grosshirnrinde und innere Organe (Translation from Russian). Berlin,VEB Verlag Volk und Gesundheit, 1953.Google Scholar
  2. Epstein, E. E.: The influence of the stimulation of interoceptors of the gallbladder on the EKG. (Vlijanie razdraženia rezeptorov sželtshnogo pusirja na EKG).Works of the Physiological Institute, Minsk,1:99–106, 1956.Google Scholar
  3. Gellhorn, E.:Autonomic Imbalance and the Hypothalamus, Minneapolis, University of Minnesota Press, 1957.Google Scholar
  4. Grastyan, E., Lissak, K., and Haznos, T.: Analysis of hypothalamic reaction reversal.Acta. Physiol. Acad. Sci. Hung.,4:253–259, 1953.Google Scholar
  5. Hess, W. R.:Das Zwischenhirn, Basel, Benno Schwabe u. Co., 1954.Google Scholar
  6. Kaada, B. R.: Somato-motor, autonomic and electrocorticographic responses to electrical stimulation of “rhinencephalic” and other structures in primates, cat and dog.Acta. Physiol. Scand.,24, Supp. 83, 1–285, 1951.Google Scholar
  7. Keller, A. D.: Ablation and stimulation of the hypothalamus: Circulatory effects.Physiol. Rev. Supp.,4:116–135, 1960.Google Scholar
  8. MacLean, P. D.: Psychosomatic disease and the “visceral brain.”Psychosomat. Med.,11:338–353, 1949.Google Scholar
  9. Owen, S. E.: A study of viscerocardiac reflexes. I. The experimental production of cardiac irregularities by visceral stimulation.Am. Heart J.,8: 496–506, 1933.CrossRefGoogle Scholar
  10. Petrowski, J. A.: Physiological and pharmacologic analysis of interoceptive reflexes from the liver and gallbladder. (Fiziologitsheski i farmakologitsheski analisis interozeptivnich refleksov s petsheni i želtshnogo pusirja.)Bull. eksp. biol. i. med.,38:3–7, 1954 (Russ.).Google Scholar
  11. Scherrer, H.: Hypothalamic stimulation and blood pressure homeostasis.Act. neuroveget.,20:205–218, 1959.CrossRefGoogle Scholar
  12. Smetankin, G. N.: On the relationship of the cerebral cortex and the hypothalamus in regulation of blood pressure. (K voprossu o vzaimootnoshenii kary bolshich polusharii i gipotalamusa v regulatsii krovjanogo davlenia.)Fiziol. Žurn. SSSR, 47:1087–1095, 1961.Google Scholar
  13. Smith, O. A., Jr., Jabbur, S. J., Rushmer, R. F., and Lasher, E. P.: Role of hypothalamic structures in cardiac control.Physiol. Rev. Supp.,4:136–141 1960.Google Scholar
  14. Tonkikh, A. V., Iljina, A. I., and Teplov, S. I.: Changes of the coronary circulation and blood pressure following stimulation of the hypothalamus. (Ismenenia koronarnogo krovoobrastshenia i krovjanogo davlenia pri rasdraženii gipotalamitsheskoi oblasti.)Fiziol. Ž., SSSR, 47:801–805, 1961.Google Scholar
  15. Tonkikh, A. V., Iljina, A. I., and Teplov, S. I.: Continuous changes of the coronary circulation of different parts of the hypothalamus. (Dlitelnie izmenenia koronarnogo krovoobrastshenia i krovjanogo davlenia posle razdraženia razlitshnich otdelov gipotalamusa.)Fiziol. Ž SSSR,48:842–849, 1962.Google Scholar

Copyright information

© Springer 1967

Authors and Affiliations

  • W. Rüdiger
    • 1
  • M. Lindemann
    • 1
  1. 1.Humboldt UniversityBerlin

Personalised recommendations