Advertisement

Conditional Reflex

, Volume 2, Issue 2, pp 96–112 | Cite as

The somatic and vegetative-regulatory behavior of the healthy organism during conditioning of the insulin effect

  • T. Hecht
  • R. Baumann
  • K. Hecht
Article
  • 12 Downloads

Abstract

Symptoms produced by repeated daily injection of insulin (3 units/kg i.v.) in dogs revealed the principle of fractional conditioning: the general behavior and changes in the cortical EEG characteristic of insulin action could become a conditional reflex (evoked by the injection of physiological saline i.v. and a CS)—while the blood sugar level, the heart rate, the EKG, and body temperature did not become CRs. This split illustrates the principle shown by Gantt that centrally-mediated effects of an agent are conditionable while those resulting only from direct peripheral action cannot become CRs. From this principle it may be assumed that the effects of insulin (behavioral, EEG) are mediated through the central nervous system, while other insulin effects (those not conditionable) are a result of peripheral action. Two methods of blood sugar determination (Hagedorn-Jensen and glucose oxidase) in both venous and arterial blood were used in these experiments, and the data resulting from 14,056 determinations were analyzed.

Keywords

Conditional Stimulus Blood Sugar Conditional Reflex Insulin Action Blood Sugar Level 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Alvares de Buylla:Acta physiol. latino-Amer. 10/2 (1960) 54.Google Scholar
  2. Androssova, S. G., et al.:Sowjetwissenschaft, naturwissenschaftliche Beiträge,4:341, 1960.Google Scholar
  3. Anochin, P. K.: Personal communication.Google Scholar
  4. Baumann, R.:Coma diabeticum, seine Pathophysiologie, Pathogenese, Symptomatik und Therapie. Berlin, VEB Verlang Volk und Gesundheit, 1959.Google Scholar
  5. Baumann, R., Mitschke, H., Hecht, K., and Treptow, K.:Das Dtsch. Ges. wesen,45:1937, 1963.Google Scholar
  6. Brozman, B., and Obediar, A.:Bratisl. lek. Listy 16, 1960.Google Scholar
  7. Bunjatjan:Fragen der hoheren Nerventatigkeit. Publishing house of the Academy of Sciences of the Armenian SSR, 1952, p. 49.Google Scholar
  8. Christoph, H.:Abriss der Klinik der Hundekrandheiten. Jena, VEB Gustav-Fischer-Verlag, 1962, p. 2.Google Scholar
  9. Festschenko, G. A., and Beljajev: Moscow, Leningrad, Academy of Medical Sciences of the USSR, 1962, p. 115.Google Scholar
  10. Forster, F. M.:Conditioning in Sensory Evoked Seizures.1:4, 1966.Google Scholar
  11. Gantt, W. H., quoted by Leibson, L. G.:Blutzucker. Moscow, Leningrad, Academy of Medical Sciences of the USSR, 1962, p. 115.Google Scholar
  12. Gantt, W. H., Katzenellenbogen, S., and Loucks, R.: Thesis of the 15th International Physiological Congress, 55, p. 88, 1935.Google Scholar
  13. Genes, S. G., Lesnoi, and Shukovskaja, quoted by Genes, S. G.:Nervensystem und innere Sekeretion. Medgis, 1955. Chapter Bauchspeicheldrüse.Google Scholar
  14. Hecht, K., Hecht, T., and Baumann, R.:Acta biol. med. germ.,15:254, 1965.Google Scholar
  15. Hecht, K., Hecht, T., and Baumann, R.:Acta biol. med. germ.,15:433, 1965.PubMedGoogle Scholar
  16. Hecht, K., Baumann, R., Hecht, T., and Mitschke, H.:Acta biol. med. germ.,15:442, 1965.PubMedGoogle Scholar
  17. Hecht K., Hecht, T., and Baumann, R.:Acta biol. med. germ.,15:451, 1965.PubMedGoogle Scholar
  18. Jankeljevitz, D. Ja.: Theses of the reports presented at the scientific symposium on central nervous regulation of glands with internal secretion, Kiev-Charkov, 1952.Google Scholar
  19. Kantorovitz, H. W., and Rybkina, J. W.:Z. nevropatol. Psichiat.,3:86, 1957.Google Scholar
  20. Katsch: Regulationskrankheit Diabetes.Med. Klinik,1:17, 36, 1946.Google Scholar
  21. Konitzer, K., Solle, M., and Viogt, S.:Acta biol. med. germ.,15:561, 1965.Google Scholar
  22. Konitzer, K., Baumann, R., Hecht, T., Hecht, K., and Mitschke, H., in R. Baumann and K. Fichtel:Kortiko-viszerale Physiologie, Pathologie und Therapie. Berlin, Akademie-Verlag, 1966, p. 155.Google Scholar
  23. Kossjakov, K. S.:Ž. vysš. nerv. Dejat. Pavlova,2:921, 1952.Google Scholar
  24. Krämer, Vogel, and Westphal:Erste Arbeitstagung über die zentrale Regulation der Funktionwn des Organismus. Leipzig, 1955, p. 202.Google Scholar
  25. Leites, S. M., and Pavlov, T. T.:Ž vysš. nerv. Dejat Pavlova,2:114, 1954.Google Scholar
  26. Litschko, A. Je.:Ž. vysš. nerv. Dejat. Pavlova,6:522, 1959.Google Scholar
  27. Maleva, J. Ja.:Klin. Med.,9:41, 1951; andŽ. vysš. nerv. Dejat. Pavlova,1:921, 1954.Google Scholar
  28. Mohnike, G.:Betrage zum Insulin-Glucagon-Problem. Leipzig, Georg Thieme Verlag, 1953.Google Scholar
  29. Nikulin, K. G.:Klin. Med.,9:39, 1951.Google Scholar
  30. Perez-Cruet, J., and Gantt, W. H.: Conditional reflex electrocardiogram of bulbocapnine: Conditioning of the T wave.Amer. Heart J.,64:61–72, 1964.CrossRefGoogle Scholar
  31. Povarinski, Ja. A., quoted by Leibson, L. G.:Blutzucker. Moscow, Leningrad, Academy of Medical Sciences of the USSR, 1962, p. 115.Google Scholar
  32. Savtschenko, W. A., quoted by Leibson, L. G.:Blutzucker. Moscow, Leningrad, Academy of Medical Sciences of the USSR, 1962, p. 116.Google Scholar
  33. Sedina, N. S., quoted by Leites, S. M., and Pavlov, G. T.:Ž. vysš. nerv. Dejat. Pavlova,2:114, 1954.Google Scholar
  34. Serova, A. S.:Z. Nervopatol. Psichiat.,9:764, 1954.Google Scholar
  35. Specht, G.:Ther. Monat.,5:205, 1959.Google Scholar
  36. Stazenko, N. P.:Z. nervopatol. Psichiat.,9:767, 1954.Google Scholar
  37. Strokina, T. B., quoted by Leibson, L. G.:Blutzucker. Moscow, Leningrad, Academy of Medical Sciences of the USSR, 1962, p. 116.Google Scholar
  38. Treptow, K.:Inaugural Dissertation. Berlin, 1965.Google Scholar

Copyright information

© Springer 1967

Authors and Affiliations

  • T. Hecht
  • R. Baumann
  • K. Hecht

There are no affiliations available

Personalised recommendations