Association in alcoholic patients between Psychopathic Traits and the additive effect of allelic forms of theCNR1 andFAAH endocannabinoid genes, and the 3′ Region of theDRD2 Gene
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Little is known about the genetic factors that underlie the comorbidity between alcohol use disorder and antisocial personality disorder. Previous studies have associated both, dopaminergic and endocannabinoid systems to severe alcoholism with non-adaptive disrupted behaviours. In this work we have examined some gene variants involved in such systems in a sample of alcoholic patients to test whether there is a relationship with antisocial traits. The genetic analysis involved the genotyping of the single nucleotide polymorphism (SNP) TaqIA located nearby theDRD2 gene, the 10-repeat allele of a variable number tandem repeats (VNTR) of theSLC6A3 gene, the C385AFAAH SNP and the 3′-UTR microsatellite ofCNR1 gene. The clinical study was performed in 137 Spanish alcohol dependent males. Antisocial Personality Disorder (DSM-IV) diagnosis was made by applying the International Personality Disorder Examination, and psychopathic traits were evaluated by the Hare’s Psychopathy Checklist Revised (PCL-R). The genotype distribution indicates there is a relationship between the TaqIA SNP,CNR1 andFAAH genes and PCL-R’s Factor 1 in alcoholic patients. This relationship seems to be additive and independent and might be responsible for 11.4% of the variance in this PCL-R subscale. Our results suggest the implication of the dopaminergic and endocannabinoid systems in those processes leading to the comorbidity of alcoholism and antisocial behaviour.
KeywordsAntisocial personality disorder Psycophathy PCL-R DRD2 CNR1 FAAH
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- Blum K, JG Cull, ER Braverman and DE Comings (1996) Reward deficiency syndrome.Am. Scientist 84, 132–145.Google Scholar
- Blum K, ER Braverman, JM Holder, JF Lubar, VJ Monastra, D Milleret al. (2000) Reward deficiency syndrome: a biogenetic model for the diagnosis and treatment of impulsive, addictive, and compulsive behaviors.J. Psychoactive Drugs 32, 1–112.Google Scholar
- Comings DE, D Muhleman, R Gade, P Johnson, R Verde, G Saucieret al. (1997) Cannabinoid receptor gene (CNR1): association with i.v. drug use.Mol. Psychiatry 2, 1611–1618.Google Scholar
- First MB, RL Spitzer, M Gibbon and JBW Williams (1995)Structured Clinical Interview for DSM-IV Axis I Disorders Patient Edition (SCID-IP, V.) (Biometric Research, New York State Psychiatric Institute:New York).Google Scholar
- Hare RD (1991)The Hare Psychopathy Checklist-Revised (Systems M-HC, Ed.) (Toronto, ON, Canada).Google Scholar
- Molto J, R Poy and R Torrubia (2000) Standardization of the Hare Psychopathy Checklist-Revised in a Spanish prison sample.J. Personal. Disord. 14, 84–96.Google Scholar