Neurotoxicity Research

, Volume 6, Issue 4, pp 327–332 | Cite as

Studies on homocysteine and dehydroepiandrosterone sulphate plasma levels in alzheimer’s disease patients and in Parkinson’s disease patients

  • S. Genedani
  • G. Rasio
  • P. Cortelli
  • F. Antonelli
  • D. Guidolin
  • M. Galantucci
  • K. Fuxe
  • L. F. Agnati


Homocysteine (HC) and dehydroepiandrosterone sulphate (DHEAS) plasma levels have been evaluated in groups of male and female patients with Parkinson’s Disease (PD) and in a group of female patients with Alzheimer’s Disease (AD) and compared with the corresponding plasma levels observed in a group of age-matched subjects. It has been confirmed that HC plasma levels are enhanced in both PD and AD patients.

As far as the DHEAS plasma levels are concerned no changes have been observed in PD patients while a marked decrease has been observed in AD patients. These results support the view that while the pro-oxidant effects of HC and its agonist action at NMDA receptors can play a role in both neu-rodegenerative diseases, the role of DHEAS is more complex and may be an important factor only in certain neurodegenerative diseases. Thus, according to the present study DHEAS is likely to be involved in AD but not in PD.


Homocysteine Alzheimer’s disease Parkinson’s disease Dehydroepiandrosterone sulphate Human patients 


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Copyright information

© Springer 2004

Authors and Affiliations

  • S. Genedani
    • 1
  • G. Rasio
    • 2
  • P. Cortelli
    • 3
  • F. Antonelli
    • 3
  • D. Guidolin
    • 4
  • M. Galantucci
    • 1
  • K. Fuxe
    • 5
  • L. F. Agnati
    • 6
  1. 1.Department of Biomedical Sciences, Section of PharmacologyUniversity of Modena and Reggio EmiliaItaly
  2. 2.Laboratory of Clinical ChemistryOspedale “Nuovo Montecchi”SuzzaraItaly
  3. 3.Institute of Clinical NeurologyUniversity of Modena and Reggio EmiliaItaly
  4. 4.Department of Human Anatomy and Physiology, Section of Human AnatomyUniversity of PadovaItaly
  5. 5.Department of NeuroscienceKarolinska InsitutetStockholmSweden
  6. 6.Department of Biomedical Sciences, Section of PhysiologyUniversity of Modena and Reggio EmiliaItaly

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