A prospective assessment of porphyrins in autistic disorders: A potential marker for heavy metal exposure
- 230 Downloads
Autism was recently associated with a urinary porphyrin pattern indicative of mercury toxicity in a large cohort of French children. The IRB of the Institute for Chronic Illnesses approved the present study. A total of 37 consecutive American patients ( 7 years-old) with autism spectrum disorders (ASDs) (Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition-DSM IV), born from 1983-1998, that presented to the Genetic Centers of America for outpatient genetic evaluations were prospectively examined for urinary prophryin levels (LabCorp, Inc.) from June 2005-June 2006. Imaging and laboratory testing were conducted on each patient to rule-out other causal factors for their ASDs. As controls, age-, sex-, and race-matched neurotypical ASD siblings were examined. An apparent dose-response effect was observed between autism severity and increased urinary coproporphyrins. Patients with non-chelated autism (2.25-fold, 83% had levels > 2 SD above the control mean) and non-chelated ASDs (2-fold, 58% had levels > 2 SD above the control mean), but not patients with non-chelated pervasive developmental delay-not otherwise specified (PDD-NOS) or Asperger’s disorder (1.4-fold, 46% had levels > 2 SD above the control mean), had significantly increased median cop rop orp hyrin levels versus controls. A significant increase (1.7-fold) in median cop rop orp hyrin levels was observed among non-chelated ASD patients versus chelated ASD patients. Porphyrins should be routinely clinically measured in ASDs, and potential ASD treatments should consider monitoring por phyrin levels. Additional research should be conducted to evaluate the potential role for mercury exposure in some ASDs.
KeywordsAutistic Chelation Developmental Delay
Unable to display preview. Download preview PDF.
- Boris M, A Goldblatt, J Galanko and SJ James (2004) Association of 5,10-methylenetetrathydrofolate reductase (MTHFR) gene polymorphisms with autistic spectrum disorders.J. Am. Phys. Surg. 9, 106–108.Google Scholar
- Bradstreet J, DA Geier, JJ Kartzinel, JB Adams and MR Geier (2003) A case-control study of mercury burden in children with autistic spectrum disorders.J. Am. Phys. Surg. 8, 76–79.Google Scholar
- Daniell WE, HL Stockbridge, RF Labbe, JS Woods, KE Anderson, DM Bissell, JR Bloomer, RD Ellefson, MR Moore, CA Pierach, WE Schreiber, A Tefferi and GM Franklin (1997) Environmental chemical exposures and disturbances of heme synthesis.Environ. Health Perspect. 105 (Suppl. 1), 37–53.PubMedCrossRefGoogle Scholar
- Environmental Working Group (2004)Overloaded? New Science, New Insights about Mercury and Autism in Susceptible Children (EWG Action Fund, Washington, DC).Google Scholar
- Windham GC, L Zhang, R Gunier, LA Croen and JK Grether (in press) Autism spectrum disorders in relation to distribution of hazardous air pollutants in the San Francisco Bay area.Environ. Health Perspect.Google Scholar